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Polyacetylene compound, extract containing same and application of polyacetylene compound

A technology of compound and polyacetylene, applied in the field of polyacetylene compound and its application, can solve the problems that the experimental method for studying the fruiting bodies of Antrodia camphorata has not been established, and the metabolites of Antrodia camphorata have not been completely studied.

Inactive Publication Date: 2013-06-19
TAIWAN LEADER BIOTECH CORP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, even though more and more researches are devoted to the development of medicinal components in Antrodia camphorata, the metabolites in the growth and maturation process of Antrodia camphorata have not yet been fully studied.
[0004] It is generally believed that the fruiting body of Antrodia camphorata is the part with the most medicinal value, but a perfect experimental method for studying the physiological composition of the fruiting body of Antrodia camphorata has not yet been established

Method used

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  • Polyacetylene compound, extract containing same and application of polyacetylene compound
  • Polyacetylene compound, extract containing same and application of polyacetylene compound
  • Polyacetylene compound, extract containing same and application of polyacetylene compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Embodiment one: Antrodia camphorata used in the present invention

[0046] The Antrodia camphorata used in the present invention was obtained from National Chung Hsing University, and four strains of AC-3, AC-5, AC-7 and AC-9 were obtained. For the needs of the experiment, these four lines were cultivated on Cinnamomum kanehirai for 9 months to obtain AC-3-9, AC-5-9, AC-7-9 and AC-9-9. Among them, in addition to the strains cultivated for 9 months, AC-9 also obtained strains cultivated for 3 months, 6 months and 12 months: AC-9-3, AC-9-6, AC-9- 12.

Embodiment 2

[0047] Embodiment 2: Obtaining Antrodia camphorata fruiting body extract

[0048] Before proceeding with the extraction step, first test the efficiency of different extraction times to optimize the extraction. In order to test the best extraction time, fresh AC-9-9 Antrodia camphorata fruit bodies were dried for 72 hours, and then crushed into powders with an average particle size of less than 0.7 mm. 5 grams of fruiting body powder were measured and placed in a flask (250 mL) and mixed with 100 mL of 75 wt% ethanol (EtOH). The Erlenmeyer flask containing the fruiting body powder and alcohol was placed in an ultrasonic shaker (Branson 5510, Branson Ultrasonic, Ontario, Canada) to achieve thorough mixing. Fruiting body powder and 75 wt% alcohol were mixed for 10, 20, 30, 60, 120 minutes (extraction time) respectively, allowed to decant and filtered in vacuo. Then, it was concentrated and dried in a rotary evaporator. The yield series obtained at different extraction times ar...

Embodiment 3

[0053] Embodiment three: analyze the composition of the extract of Antrodia camphorata AC-9-9 obtained in embodiment two

[0054] In order to more completely understand the components contained in the fruiting body extract of Antrodia camphorata, this example uses high-pressure liquid chromatography (HPLC) to further separate the extract obtained in Example 1.

[0055] The high-pressure liquid chromatography method used in this example is an Agilent 1100HPLC system equipped with a UV detector (UV detector). The stationary phase was a carbon 18 column (Luna C18 column; 250×10.0 mm, Phenomenex, Torrance CA). The mobile phase is a mixture of the following three solutions: (A) water; (B) methanol (MeOH); (C) acetonitrile (acetonitrile). The chromatographic gradient (gradient elution profile) is as follows: 0~5 minutes, A:B:C=40:30:30 (isocratic); 5~95 minutes, A:B:C=40:30:30 to A : B: C = 10: 10: 80 (linear gradient); 95 ~ 105 minutes, A: B: C = 10: 10: 80 to A: B: C = 0: 0: 100...

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Abstract

The invention relates to a polyacetylene compound and application thereof. The polyacetylene compound is separated from sporophore of antrodia cinnamomea and has the effect of inhibiting generation of nitric oxide, so the polyacetylene compound can be used for preparing a pharmaceutical composition having an anti-inflammatory effect. The invention improves that the sporophore of antrodia cinnamomea has a physiological metabolism substance with representative significance, and the substance can be applied in evaluation of quality of antrodia cinnamomea.

Description

technical field [0001] The invention relates to a polyacetylene compound and its application, in particular to a polyacetylene compound extracted from Antrodia camphorata and its application. Background technique [0002] Antrodia cinnamomea, also known as Antrodia cinnamomea, belongs to the perennial fungi of the order Aphyllophorales and the family Polyporaceae. It is a unique fungus in Taiwan. Antrodia camphorata can only parasitize on the inner wall of the hollow decaying heartwood of Cinnamoum kanehirai Hay. Since the camphor tree is a very rare protected tree species in Taiwan, and the growth rate of Antrodia camphorata is slow, the number of Antrodia camphorata is also very rare. Although driven by market demand, the current research has been able to break through the limitation that Antrodia camphorata can only parasitize on camphor trees, but the price of Antrodia camphorata is still high because of its high-profile medicinal value. [0003] Taiwanese traditional ...

Claims

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Application Information

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IPC IPC(8): C07D317/64A61K31/36A61K36/07A61P29/00G01N30/02
Inventor 王升阳
Owner TAIWAN LEADER BIOTECH CORP
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