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Industrialization production technology for extracting ginkgolic acid and bilobalide from Ginkgo testa

A technology of ginkgo exotesta and ginkgolide, which is applied in the field of industrial production technology to extract ginkgolic acid and ginkgolide, which can solve the problems of complex and cumbersome extraction process, impossibility of popularization and application, and high operation requirements, so as to achieve simple process and improve utilization Good value and killing effect

Inactive Publication Date: 2013-06-19
张加明 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the commonly used extraction methods are organic solvent extraction, supercritical CO 2 Extraction method, water extraction-resin method, high-speed gust flow chromatography extraction method, cell tissue culture synthesis extraction method, resin extraction method, enzyme extraction method, etc., because there are many types of R groups on ginkgolic acid and ginkgolide, the above extraction The method is only suitable for the extraction of a single type of ginkgolic acid or ginkgolide. Its extraction process is complicated and cumbersome, with high operation requirements, long time and high cost, and cannot be popularized and applied in large-scale industrial production.

Method used

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  • Industrialization production technology for extracting ginkgolic acid and bilobalide from Ginkgo testa
  • Industrialization production technology for extracting ginkgolic acid and bilobalide from Ginkgo testa

Examples

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Embodiment 1

[0033] A kind of industrial production technology of extracting ginkgolic acid and ginkgolide from ginkgo testa, is characterized in that comprising the following steps:

[0034] (1) Grind the washed ginkgo testa until fine, pass through 30 mesh, add water 5 times its weight, stir and soak for 5 hours;

[0035] (2) Centrifuge the soaked mixed solution to remove slag, pump the filtrate into the concentration pot, fractionate the components at 48°C under a vacuum of 0.08Mpa, and concentrate them;

[0036] (3) Add 10% hydrochloric acid to the concentrated solution to adjust the pH value to 3, cool to 10°C, brown crystals are precipitated, and 60% ginkgolic acid is obtained by suction filtration;

[0037] (4) After fully dissolving the brown crystals in step (3) with ethanol at 50°C, filter out the insoluble matter, cool to 20°C, precipitate light brown crystals, and filter to obtain 90% ginkgolic acid;

[0038] (5) Add the light brown crystals in step (4) to 5 times the weight o...

Embodiment 2

[0043] A kind of industrial production technology of extracting ginkgolic acid and ginkgolide from ginkgo testa, is characterized in that comprising the following steps:

[0044] (1) Grind the washed ginkgo testa until fine, pass through 60 mesh, add water with 8 times the weight, stir and soak for 8 hours;

[0045] (2) Centrifuge the soaked mixed solution to remove slag, pump the filtrate into the concentration pot, fractionate the components at 60°C under a vacuum of 0.085Mpa, and concentrate them;

[0046] (3) Add 20% hydrochloric acid to the concentrated solution to adjust the pH value to 2.5, cool to 2°C, brown crystals are precipitated, and 65% ginkgolic acid is obtained by suction filtration;

[0047] (4) After fully dissolving the brown crystals in step (3) with ethanol at 60°C, filter out the insoluble matter, cool to 13°C, precipitate light brown crystals, and filter to obtain 93% ginkgolic acid;

[0048](5) Add the light brown crystals of step (4) into water with 6...

Embodiment 3

[0053] A kind of industrial production technology of extracting ginkgolic acid and ginkgolide from ginkgo testa, is characterized in that comprising the following steps:

[0054] (1) Grind the washed ginkgo testa until fine, pass through 80 mesh, add water 10 times the weight, stir and soak for 12 hours;

[0055] (2) Centrifuge the soaked mixed solution to remove slag, pump the filtrate into the concentration pot, fractionate the components at 70°C under a vacuum of 0.09Mpa, and concentrate them;

[0056] (3) Add 30% hydrochloric acid to the concentrated solution to adjust the pH value to 2, cool to -5°C, brown crystals are precipitated, and 70% ginkgolic acid is obtained by suction filtration;

[0057] (4) After fully dissolving the brown crystals in step (3) with ethanol at 70°C, filter out the insoluble matter, cool to -5°C, precipitate light brown crystals, and filter to obtain 95% ginkgolic acid;

[0058] (5) Add the light brown crystals in step (4) to 8 times the weight...

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Abstract

The invention relates to an industrialization production technology for extracting ginkgolic acid and bilobalide from Ginkgo testa. The technology comprises the following steps: leaching Ginkgo testa; separating, concentrating and fractionating leaching extracts; adjusting a pH value of the concentrated liquid; isolating a crude extract of ginkgolic acid; crystallizing, recrystallizing, and decolorizing by alkali liquor and acid precipitation, and further purifying the ginkgolic acid; conducting extraction and back extraction on a concentrated mother liquor, after adjusting a pH value; acidifying, concentrating, cooling and filtering to obtain a bilobalide crude product; and dissolving the crude product with ethanol and conducting column separation to obtain bilobalide with high purity. The invention employs acid solution to regulate the pH value of the solution containing ginkgolic acid or bilobalide, and precipitates the ginkgolic acid or bilobalide by a common ion effect. The technology has the advantages of simple process, convenient operation, low cost, high extraction rate and high extraction purity, can rapidly extract ginkgolic acid and bilobalide in large amount from Ginkgo testa, and is suitable for requirements of industrial production.

Description

technical field [0001] The invention relates to comprehensive utilization of ginkgo testa, in particular to an industrialized production technology for extracting ginkgolic acid and ginkgolide from ginkgo testa. Background technique [0002] Ginkgo tree is a unique tree species in my country, and it is also an important economic plant. It is not only called a living fossil, but also a treasure. In recent years, ginkgo and its related products have been paid more and more attention in the international market. Developed countries such as Europe and the United States have carried out in-depth development of it, and have successively developed a variety of medicines, health products and cosmetics, which have made considerable profits. my country is also paying more and more attention to the comprehensive utilization of ginkgo fruit and ginkgo leaves. However, the ginkgo testa, which accounts for most of the weight of ginkgo fruit, is generally discarded as waste, which has not...

Claims

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Application Information

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IPC IPC(8): C07C65/05C07C51/42C07D493/22A01N37/40A01P7/04A01P1/00
Inventor 薛锋张加明彭盘英薛新建奚照寿
Owner 张加明
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