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Cavity-type dynamic-filling bioreaction device

A technology of biological reaction device and reaction device, applied in biochemical equipment and methods, tissue cell/virus culture device, biochemical instrument, etc., can solve the problems of restricting the mass production of tissue engineering products and the inability to distribute cells uniformly

Active Publication Date: 2013-06-05
SHANGHAI SIXTH PEOPLES HOSPITAL
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0006] Although the existing bioreactors can already provide a three-dimensional culture environment for cells on tissue-engineered bioscaffolds, they either cannot distribute the cells evenly in the bioscaffolds, or they need to be reorganized when constructing cell-bioscaffold complexes of different specifications. Custom-made reactors and the ability to construct only hollow cell-bioscaffold complexes limit mass production of tissue engineered products

Method used

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  • Cavity-type dynamic-filling bioreaction device
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  • Cavity-type dynamic-filling bioreaction device

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Embodiment Construction

[0024] The invention provides a chamber type dynamic perfusion biological tissue reaction device, which can promote the proliferation and differentiation of cells and tissues to form tissue engineering components by adjusting the flow rate, stress, nutrition and active substance content of cell culture fluid in the device.

[0025] The cavity-type dynamic perfusion tissue reaction device of the present invention utilizes the principle of human blood circulation and adopts the method of dynamic liquid perfusion culture to make different cells-biological scaffolds compound inside each cultured cell-biological scaffold complex and in the same cavity. Cells in the body can always obtain sufficient and balanced nutrition, so that they can better divide and proliferate, so as to form a substitute for tissues or organs with good functions.

[0026] The present invention will be described in further detail below through examples, so as to better understand the content of the present in...

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Abstract

The invention provides a cavity-type dynamic-filling bioreaction device comprising a biological sample culture component, a nutrient solution flowing pipe and a power pump component. The biological sample culture component is provided with an in-out port communicated with the nutrient solution flowing pipe. The biological sample culture component comprises an upper cover body, a container body and a sample bearing frame, wherein the upper cover body is connected with the container body, a supporting ring is arranged on the inner wall of the container body, the sample bearing frame is arranged on the supporting ring, a supporting block is arranged on the inner side of the sample bearing frame, a sample bearing plate is arranged in a cavity formed by the supporting block and the sample bearing frame, and culture through holes are longitudinally formed in the sample bearing plate. The nutrient solution flowing pipe comprises an output pipe and an input pipe, wherein the output pipe and the input pipe are respectively connected with the power pump component.

Description

technical field [0001] The present invention relates to a device for cultivating samples in the fields of plant, animal and human tissue engineering, and in particular to a cavity-type device that promotes the proliferation and differentiation of cells and tissues by continuously and dynamically supplying nutrients and regulating the stimulation of mechanics and biologically active substances. Dynamic perfusion biological tissue reaction device. Background technique [0002] Tissue engineering combines the principles of cell biology and engineering to study the anatomical structure and physiological functions of normal cells, tissues or organs, so as to produce artificial substitutes that can improve, repair or rebuild the structure and function of damaged tissues. The method is to obtain a small amount of tissue from the body, obtain seed cells after separation and expansion, inoculate them into biological scaffolds, form tissue engineering components through in vitro cultu...

Claims

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Application Information

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IPC IPC(8): C12M3/00
Inventor 范存义刘珅金芳纯卢建熙
Owner SHANGHAI SIXTH PEOPLES HOSPITAL
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