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Collagen covalent cross-linking hydrogel and preparation method thereof

A collagen and covalent cross-linking technology, used in medical science, prosthesis, etc., can solve problems such as excessive degradation time, allergies, redness and swelling, and achieve prolonged degradation time, weak immune rejection, and good mechanical properties. Effect

Inactive Publication Date: 2013-06-05
NORTHWEST UNIV(CN)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, some fillers and anti-wrinkle products used in the medical beauty industry generally have problems such as redness, swelling, tumor-like lumps, and rapid absorption after use, which cannot be used or cannot fully meet the needs of beauty and anti-wrinkle
Even Shuangmei Collagen and Ivelan approved by the State Food and Drug Administration, although the effect is good, there are still redness, allergies, and too fast degradation time, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Step 1: dissolving the collagen with water for injection into a collagen solution with a mass fraction of 2.0%;

[0035] Among them, collagen is animal collagen.

[0036] Step 2: dissolving chitosan into a mass fraction of 1.0% chitosan solution with dilute acid solution;

[0037] The degree of deacetylation of chitosan is 80%, and the molecular weight of chitosan is 1×10 5 Dalton;

[0038] Dilute hydrochloric acid is selected as the dilute acid solution, and the mass fraction is 0.5%.

[0039] Step 3: dissolving the dialdehyde starch with water for injection into a dialdehyde starch solution with a mass fraction of 2.0%;

[0040] The molecular weight of dialdehyde starch is 1.0×10 6 , The aldehyde content is 30%.

[0041] Step 4: Mix the collagen solution and the chitosan solution at a volume ratio of 1:3 at room temperature, and stir for 10 minutes to make them evenly mixed, and at the same time adjust the pH value to 7.5;

[0042] Step 5: According to the volu...

Embodiment 2

[0050] Step 1: dissolving the collagen with water for injection into a collagen solution with a mass fraction of 2.0%;

[0051] Wherein, the collagen is human-like collagen.

[0052] Step 2: dissolving chitosan into a chitosan solution with a mass fraction of 2.0% with dilute acid solution;

[0053] The degree of deacetylation of chitosan is 85%, and the molecular weight of chitosan is 2×10 5 Dalton;

[0054] Dilute hydrochloric acid is selected as the dilute acid solution, and the mass fraction is 0.5%.

[0055] Step 3: dissolving the dialdehyde starch with water for injection into a dialdehyde starch solution with a mass fraction of 3.0%;

[0056] The molecular weight of dialdehyde starch is 2.0×10 6 , The aldehyde content is 30%.

[0057] Step 4: Mix the collagen solution and the chitosan solution at a volume ratio of 1:2 at room temperature, and stir for 15 minutes to make them evenly mixed, and at the same time adjust the pH value to 7.5;

[0058] Step 5: According...

Embodiment 3

[0065] Step 1: dissolving collagen with water for injection into a collagen solution with a mass fraction of 3.0%;

[0066] Among them, collagen is animal collagen.

[0067] Step 2: dissolving chitosan into a mass fraction of 3.0% chitosan solution with dilute acid solution;

[0068] The degree of deacetylation of chitosan is 85%, and the molecular weight of chitosan is 3×10 5 Dalton;

[0069] The dilute acid solution is dilute acetic acid with a mass fraction of 0.5%.

[0070] Step 3: dissolving the dialdehyde starch with water for injection into a dialdehyde starch solution with a mass fraction of 3.0%;

[0071] The molecular weight of dialdehyde starch is 3.0×10 6 , The aldehyde content is 35%.

[0072] Step 4: Mix the collagen solution and the chitosan solution at a volume ratio of 1:1 at room temperature, and stir for 20 minutes to make them evenly mixed, and at the same time adjust the pH value to 7.5;

[0073] Step 5: According to the volume ratio of dialdehyde s...

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Abstract

The invention particularly relates to a collagen covalent cross-linking hydrogel and a preparation method thereof. An injectable hydrogel causes the problems of red and swollen, warty bumps and too fast absorption and the like after being used, and can not be used or can not fully meet requirements of beauty and wrinkle reduction. According to the preparation method, the Schiffbase reaction principle and the Acetalization reaction principle are utilized. By mass, 2.0%-5.0% of Dialdehyde starch solution, 2.0%-4.0% of collagen solution and 1.0%-5.0% of chitosan solution are stirred in a mixed mode with the size ratio of (1-4): (1-3): (1-3) to obtain the covalent cross-linking hydrogel. The prepared collagen covalent cross-linking hydrogel can form stable gel within a temperature range of 4-40 DEG C, and the gel takes 2-3 minutes in forming time, and is good in mechanical performance, and poor in immune rejection reaction. Degradation time of the gel is obviously prolonged and can reach about 12 months, and the gel is safer and more effective when applied to treat skin dimpling, wound trauma and wrinkles ( crows-feet and forehead wrinkles and frown lines and the like).

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a collagen covalently crosslinked hydrogel and a preparation method thereof. Background technique [0002] With the development of biological and non-biological materials and tissue engineering, injectable hydrogels have become one of the most important types of injectable materials in the field of biomedicine. At present, some fillers and anti-wrinkle products used in the medical beauty industry generally have problems such as redness, swelling, tumor-like lumps, and rapid absorption after use, which cannot be used or cannot fully meet the needs of beauty and anti-wrinkle. Even Shuangmei Collagen and Evalan approved by the State Food and Drug Administration, although the effect is good, there are still redness, allergies, and too fast degradation time. Improving biostability and biocompatibility are two key technical bottlenecks in preparing hydrogels for tissue...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/24C08J3/075C08L89/00C08L5/08A61L27/24A61L27/20
Inventor 范代娣马晓轩杜玉章
Owner NORTHWEST UNIV(CN)
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