Application of Aphanamixoid A in medicines curing acute gout

Abstract

The invention provides a new use of Aphanamixoid A in medical science, and particularly relates to application of preparation of the Aphanamixoid A in medicines curing acute gout. Experiment research indicates that the Aphanamixoid A has protective effect on an acute gout model in which urate causes damage of vascular endothelial cell, and restrains expression of intercellular cell adhesion molecule (ICAM)-1. Therefore, the Aphanamixoid A can be used for preparation of the medicines curing acute gout inflammation. Use of the Aphanamixoid A in preparation of the medicines curing the acute gout is made public for the first time. Due to the fact that skeleton type belongs to completely novel skeleton type, and the Aphanamixoi A has an unexpectedly high activity of preventing and curing the acute gout, probability of other compounds giving any revelation for the Aphanamixoi A does not exist, outstanding substantive features are provided, meanwhile, prominent improvement is evidently possessed in preventing and curing the acute gout.

Description

technical field [0001] The present invention relates to the new application of traditional Chinese medicine extract Aphanamixoid A in medicine, in particular to the application of Aphanamixoid A in preparing medicine for treating acute gout. Background technique [0002] Gout, also known as gouty arthritis, is a disease caused by the disorder of purine metabolism in the body. It is manifested by excessive uric acid in the blood, and it is easy to cause urate (MSU) to crystallize in joints and other tissues. The acute attack of gout is due to the local neutrophil infiltration and inflammatory response caused by MSU deposited in the joints. [0003] Western medicine selects three kinds of medicines for use in the acute attack stage of gout: colchicine, non-steroidal anti-inflammatory drugs and corticosteroids. The mechanism of action of colchicine is to bind to the tubulin of neutrophils, thereby hindering the activity of granulocytes and inhibiting granulocyte infiltration. ...

AI Technical Summary

Problems solved by technology

Although they have fast anti-inflammatory and analgesic effects, their toxic and side effects are also quite obvious. For example, the effective dose of colchicine is similar to the dose that produces diarrhea and other gastrointestinal symptoms. Absolutely contraindicated in the case of bleeding, and the administration of phenylbutazone for as short as 3 weeks can also cause severe neutropenia or aplastic anemia

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