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Applications of Chinese starjasmine stem aglycon, burdock aglycon and Chinese starjasmine stem glucoside as dibenzyl butyrolactone compounds to preparation of medicaments for treating hepatitis viruses

A technology of arctigenin and terroshigenin, which is applied in application, antiviral agent, food preparation, etc., can solve the problem of no anti-hepatitis C virus effect and achieve significant anti-hepatitis C virus activity Effect

Inactive Publication Date: 2013-05-08
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, there have been no relevant reports on the anti-hepatitis C virus effects of the dibenzylbutyrolactone compounds, tertogenin, tertogenin, and arctigenin in scorpion vine.

Method used

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  • Applications of Chinese starjasmine stem aglycon, burdock aglycon and Chinese starjasmine stem glucoside as dibenzyl butyrolactone compounds to preparation of medicaments for treating hepatitis viruses
  • Applications of Chinese starjasmine stem aglycon, burdock aglycon and Chinese starjasmine stem glucoside as dibenzyl butyrolactone compounds to preparation of medicaments for treating hepatitis viruses
  • Applications of Chinese starjasmine stem aglycon, burdock aglycon and Chinese starjasmine stem glucoside as dibenzyl butyrolactone compounds to preparation of medicaments for treating hepatitis viruses

Examples

Experimental program
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Effect test

Embodiment 1

[0028] Example 1 Anti-hepatitis C virus test of strogenin, arctigenin and stroganoside

[0029] 1. Experimental drugs, reagents and materials

[0030] 1. Compounds: strogenin, arctigenin, strogenin.

[0031] 2. Cell line Huh7, human liver cancer cell line (see: Yimin Tong, Yongzhe Zhu, Xueshan Xia, Yuan Liu, et al. Tupaia CD81, SR-BI, Claudin-1, and Occludin Support Hepatitis C Virus Infection, JOURNAL OF VIROLOGY, 2011; 85(6): 2793-2802; Jin Zhong, Pablo Gastaminza, Guofeng Cheng, et al. Robust hepatitis C virus infection in vitro, PNAS, 2005; 102(26):9294-9299).

[0032] 3. Cell culture medium, prepared, which contains 10% fetal bovine serum, 0.03% glutamine, non-essential amino acids, ampicillin and streptomycin 100U / ml, adjust the pH to 7.4.

[0033] 4. Cell digestion solution, prepared, containing 0.25% trypsin, prepared with phosphate buffer.

[0034] 5. HCVcc: cell-cultured infectious hepatitis C virus (see: Yimin Tong, Yongzhe Zhu, Xueshan Xia, Yuan Liu, et al. Tu...

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Abstract

This invention relates to applications of Chinese starjasmine stem aglycon, burdock aglycon and Chinese starjasmine stem glucoside as dibenzyl butyrolactone compounds to the preparation of medicaments for treating hepatitis viruses and particularly hepatitis C viruses. The three compounds can be also used for preparing liver protection food or healthcare product. The invention provides the new applications of the Chinese starjasmine stem aglycon, the burdock aglycon and the Chinese starjasmine stem glucoside. The study on tests on resisting hepatitis C viruses shows that the three compounds have very significant hepatitis C virus resisting activity and can serve as the sources of novel active components for developing the medicaments for resisting hepatitis viruses, the liver protection food and the healthcare product.

Description

technical field [0001] The present invention relates to the new application of dibenzylbutyrolactone compound strogenin, arctigenin and strogenin, specifically, the dibenzylbutyrolactone compound strogenin, arctigenin Application of aglycone and tergoside in the preparation of drugs for preventing and treating hepatitis virus. Background technique [0002] Trachelogenin (trachelogenin), arctigenin (arctigenin), and tracheloside (tracheloside) are derived from trachelogenin, a plant of the family Apocynaceae. Trachelospermum jasminoside Dibenzylbutyrolactones isolated from (Lindl.) Lem, details can be found in the following literature: ①Tan XQ (Tan Xingqi), Chen HS (Chen Haisheng), Liu RH (Liu Runhui), et al. Lignans from Trachelospermum jasminoides [J]. Planta Med. 2005; 71(1):93-95; ②Inagaki I, Hisada Y, Nishibe S. Lignans of Trachelospermum asiaticum var. intermedium . I. Isolation and structures of Arctiin, Matairesinoside and Tracheloside[J]. Chem Pharm Bull 1972; 2...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61P31/14A23L1/30
Inventor 陈海生朱勇喆谭兴起钱汐晶金永生戚中田
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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