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Enteric-coated tilmicosin slow-release micro-capsule preparation and preparation method thereof

A tilmicosin and slow-release technology, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, etc. Food intake and other issues, to achieve good palatability, improve drug efficacy, and avoid the first-pass effect of the liver

Inactive Publication Date: 2015-01-07
GUANGZHOU GREAT BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, like ordinary powders, the taste is extremely bitter, which affects animal feed intake, is completely dissolved in gastric acid, has no slow-release function, and has poor antibacterial and growth-promoting effects

Method used

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  • Enteric-coated tilmicosin slow-release micro-capsule preparation and preparation method thereof
  • Enteric-coated tilmicosin slow-release micro-capsule preparation and preparation method thereof
  • Enteric-coated tilmicosin slow-release micro-capsule preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A preparation method of enteric-coated tilmicosin sustained-release microcapsule preparation, comprising the following steps:

[0029] Step 1. Add tilmicosin raw powder to the auxiliary material at a temperature of 70°C to 100°C, and coat it to form an inner core layer;

[0030] Step 2. Spray coating coating layer material on the surface of the inner core layer in the step 1 to obtain approximately spherical microcapsule particles with a diameter of 250 μm to 800 μm;

[0031] Step 3, drying the microcapsule particles prepared in step 2 to obtain the finished product.

[0032] In the present invention, the mass percentage of tilmicosin raw powder is 10% to 50%, and in this embodiment, the mass percentage of tilmicosin is preferably 10%.

[0033] Commonly used auxiliary materials are stearic acid, glyceryl monostearate, stearyl alcohol, saturated triglycerides, monoglycerides, fat powder and paraffin, in the present invention auxiliary materials are stearic acid, glycery...

Embodiment 2

[0042] Same as Example 1, the difference is:

[0043] The mass percentage of tilmicosin is 20%, and the auxiliary material is a mixture of glyceryl monostearate and fat powder, wherein the mass percentage of glyceryl monostearate is 50%, and the mass percentage of fat powder is 25%. The layer material is hypromellose phthalate, its mass percentage is 5%, and its melting temperature is 95°C.

Embodiment 3

[0045] Same as Example 1, the difference is:

[0046]The mass percentage of tilmicosin is 30%, and the auxiliary material is a mixture of glyceryl monostearate and fat powder, wherein the mass percentage of glyceryl monostearate is 40%, and the mass percentage of fat powder is 20%. The layer material is hypromellose phthalate, its mass percentage is 10%, and its melting temperature is 90°C.

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Abstract

The invention relates to an enteric-coated tilmicosin slow-release micro-capsule preparation and a preparation method thereof and belongs to the field of tilmicosin preparations. The enteric-coated tilmicosin slow-release micro-capsule preparation provided by the invention comprises an inner core layer and a coating layer, wherein the inner core layer comprises tilmicosin raw powder and an auxiliary material; the auxiliary material comprises one or more than one of stearic acid, glycerin monostearate, stearyl alcohol, saturated triglyceride, monoglyceride and paraffin; and the coating layer is made from one or more than one of cellulose acetate phthalate, hydroxypropyl methyl cellulose phthalate, acrylic resin, polyvinyl acetate phthalate and acetic hydroxypropyl methylcellulose succinate. The preparation method comprises the following steps of: carrying out primary coating on the tilmicosin raw powder and the auxiliary material, carrying out secondary coating by using the materials of the coating layer, and drying to obtain the finished product. According to the invention, the tilmicosin is coated by using high polymer materials and the coated tilmicosin micro-capsule is undissolved in acid environment and slowly dissolved in alkaline environment of enteric canal, so that the purpose of slow release is achieved and the action time of the tilmicosin is prolonged.

Description

technical field [0001] The invention belongs to the field of tilmicosin preparations, and relates to an enteric-coated tilmicosin sustained-release microcapsule preparation and a preparation method thereof. Background technique [0002] Tilmicosin is a macrolide broad-spectrum antibiotic for livestock and poultry. It is mainly used to prevent and control livestock pneumonia, avian mycoplasma disease and mastitis of lactating animals. It has been widely used in animal husbandry production. At present, the dosage forms included in the national standards include premixes, soluble powders, solutions and injections. [0003] Tilmicosin tastes extremely bitter, has poor palatability, is irritating to gastric mucosa, and affects the feed intake of animals. At the same time, general tilmicosin premixes and powders have poor fluidity and low dispersibility. Difficult to mix when dosing. At present, domestic tilmicosin preparations mainly include the following types: [0004] 1. Or...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/52A61K31/706A61K47/38A61K47/32A61P31/04
Inventor 魏平华程怀灵张萍
Owner GUANGZHOU GREAT BIOLOGICAL TECH
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