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Medicine preparation for treating postmenopausal osteoporosis

A technology for osteoporosis and pharmaceutical preparations, applied in the field of compound preparations of alfacalcidol and tibolone

Inactive Publication Date: 2013-05-01
CP PHARMA QINGDAO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The technical problem to be solved by the present invention is to overcome the defects of existing single preparations and provide a compound preparation of alfacalcidol and tibolone. High utilization, rapid onset of effect, convenient administration, can maximize the pharmacological effects of alfacalcidol and tibolone, and make up for the defects in the efficacy of a single preparation, and can become a treatment for postmenopausal osteoporosis. Excellent Pharmaceutical Preparations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0040] 1. Liquid preparation:

[0041] Dissolve 5.0mg of alfacalcidol and 25.0g of tibolone in 80ml of absolute ethanol, dissolve 224mg of BHA and 168mg of citric acid in 20ml of absolute ethanol, put the above two ethanol solutions into soybean oil, and mix well to obtain The liquid medicine of this capsule;

[0042] 2. Preparation of soft capsule material:

[0043] Take an appropriate amount of red pigment (erythrosine) and dissolve it with a small amount of water, add it to 9600g of dry gelatin, add 1200g of sorbitol, 2400g of glycerin, add an appropriate amount of water, heat to dissolve, and mix well to obtain the soft capsule material of this soft capsule;

[0044] 3. Filling of soft capsules:

[0045] In the case of maintaining the dynamic (stirring) of the liquid medicine, by adjusting the circulation pump pressure, the circulation pressure of the filling pipeline is maintained, so that the liquid medicine can be filled with a uniform concentration; filling at a cert...

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PUM

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Abstract

The invention provides a medicine preparation for treating postmenopausal osteoporosis and belongs to the technical field of medicines. The medicine preparation contains alfacalcidol, tibolone and necessary pharmaceutical excipients. The medicine preparation for treating postmenopausal osteoporosis, provided by the invention, has the advantages of good disintegration, good absorbing degree, high bioavailability, quick curing effect and convenience for taking. Pharmacological actions of the alfacalcidol and the tibolone can be taken to a maximum extent, the defect of single preparation in efficacy is compensated, and the medicine preparation is an excellent medicine preparation for treating the postmenopausal osteoporosis.

Description

technical field [0001] The invention relates to a pharmaceutical preparation, in particular to a compound preparation of alfacalcidol and tibolone, belonging to the technical field of medicine. Background technique [0002] Osteoporosis (OP) is a metabolic bone disease characterized by low bone mass and microarchitectural destruction of bone tissue, leading to increased bone fragility and susceptibility to fracture. Its greatest hazard is the occurrence of fragility fractures, that is, fractures can occur under slight collisions or external forces. [0003] Osteoporosis is a common senile disease. It has been called a "silent epidemic" by the World Health Organization (WHO). It ranks seventh among common and frequently-occurring diseases in the world, and the number of patients currently exceeds 250 million. people. [0004] According to statistics, the number of osteoporosis patients in my country was about 84 million in 1999, 120 million in 2010, and 212 million by 2050....

Claims

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Application Information

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IPC IPC(8): A61K31/593A61K31/567A61K9/48A61P19/10
Inventor 王明刚任莉陈阳生孙桂玉刘晓霞翟翠云
Owner CP PHARMA QINGDAO CO LTD
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