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Tea tree oil antibacterial microcapsule and preparation method and application thereof

A technology of tea tree oil and microcapsules, which is applied in the direction of antibacterial drugs, pharmaceutical formulations, cosmetic preparations, etc., to achieve high yield, convenient use, and biodegradable effects

Active Publication Date: 2014-12-03
GUANGDONG FOOD & DRUG VOCATIONAL COLLEGE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Usually it is difficult for one material to have the above properties at the same time. In practical applications, several wall materials are often used in combination.

Method used

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  • Tea tree oil antibacterial microcapsule and preparation method and application thereof
  • Tea tree oil antibacterial microcapsule and preparation method and application thereof
  • Tea tree oil antibacterial microcapsule and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] (1) Dissolve 2 mass parts carboxymethyl chitosan (CPCTS, molecular weight 50,000, carboxylation degree 70.0%, Zhejiang Jinke Biochemical Co., Ltd.) in 98 mass parts deionized water to prepare 2.0% mass fraction Carboxymethyl chitosan aqueous solution was added with 0.5 parts by mass of dimethyldiallylammonium chloride-acrylic acid copolymer (viscosity average molecular weight 4500, Guangzhou Chaohui Chemical Technology Co., Ltd.), stirred and dissolved to obtain solution I.

[0060] (2) Dissolve 3 parts by mass of chitosan (Chitosan, molecular weight 300,000, deacetylation degree 95.0%, Zhejiang Jinke Biochemical Co., Ltd.) in 97 parts by mass of deionized water, stir, and adjust the pH value to 3.0 with glacial acetic acid , chitosan is completely dissolved, and is prepared into a chitosan aqueous solution with a mass percentage of 3.0%; add 2 mass parts Tween-80 and 4 mass parts tea tree oil (cosmetic grade, Australia AusoilPTYLTD company), 4500r to the chitosan aqueou...

Embodiment 2

[0070] (1) 2 mass parts carboxymethyl chitosan (CPCTS, molecular weight 100,000, carboxylation degree 65.0%, Zhejiang Jinke Biochemical Co., Ltd.) was dissolved in 98 mass parts deionized water to prepare 2.0% mass fraction Add 0.2 parts by mass of polydimethyldiallylammonium chloride (viscosity average molecular weight: 3000, Guangzhou Chaohui Chemical Technology Co., Ltd.) to an aqueous solution of carboxymethyl chitosan, stir and dissolve to obtain solution I.

[0071] (2) Dissolve 3 parts by mass of chitosan (Chitosan, molecular weight 500,000, degree of deacetylation 95.0%, Zhejiang Jinke Biochemical Co., Ltd.) in 97 parts by mass of deionized water, stir, and adjust the pH value to 3.0 with glacial acetic acid , make chitosan dissolve completely, be mixed with the chitosan aqueous solution of mass percent 3.0%; Add 0.5 mass part Tween-20, 0.5 mass part Span-80 and 2 mass parts tea tree oil (cosmetics) in chitosan aqueous solution Grade, Australia Ausoil PTY LTD company),...

Embodiment 3

[0075] (1) Dissolve 2 mass parts carboxymethyl chitosan (CPCTS, molecular weight 80,000, carboxylation degree 67.85%, Zhejiang Jinke Biochemical Co., Ltd.) in 98 mass parts deionized water to prepare 2.0% mass fraction Carboxymethyl chitosan aqueous solution was added with 0.4 parts by mass of dimethyldiallylammonium chloride-acrylamide copolymer (viscosity average molecular weight: 5000, Guangzhou Chaohui Chemical Technology Co., Ltd.), stirred and dissolved to obtain solution I.

[0076] (2) Dissolve 3 parts by mass of chitosan (Chitosan, molecular weight 450,000, degree of deacetylation 95.0%, Zhejiang Jinke Biochemical Co., Ltd.) in 97 parts by mass of deionized water, stir, and adjust the pH value to 3.0 with glacial acetic acid , chitosan is completely dissolved, and is prepared into an aqueous chitosan solution with a mass percentage of 3.0%; 2 mass parts Tween-80 and 3 mass parts tea tree oil (cosmetic grade, Australia Ausoil PTY LTD company) are added to the chitosan a...

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Abstract

The invention discloses a tea tree oil antibacterial microcapsule and a preparation method and application thereof. The method comprises the following steps of mixing a stabilizer and aqueous solution of carboxymethyl chitosan, and stirring the mixture to dissolve the stabilizer to obtain solution I; adding an emulsifier and a grease into the aqueous solution of carboxymethyl chitosan, and homogenizing to obtain solution II; adding the solution II into the solution I, under stirring at the constant temperature of 40 to 60 DEG C, adjusting the pH value of the solution to be between 5.0 to 6.5, and reacting to obtain re-coagulating solution, wherein the using amount of the solution II and the solution I is determined according to the carboxymethyl chitosan, and the proportion by mass of the carboxymethyl chitosan is 1:1.5; and cooling the re-coagulating solution, adjusting the pH value to be between 6.5 to 8.0, adding a curing agent to react and cure to obtain a tea tree oil microcapsule emulsion, and cooling and drying the tea tree oil microcapsule emulsion to obtain the tea tree oil antibacterial microcapsule. The preparation method is simple, the particle size is controllable, and the obtained microcapsule is regular in shape, high in yield and relatively high in packaging rate and medicine loading capacity. When the microcapsule is applied to a water-based formula, the stability is greatly improved.

Description

technical field [0001] The invention belongs to the technical field of microcapsule preparation, and in particular relates to a tea tree oil antibacterial microcapsule and its preparation method and application. Background technique [0002] "Tea tree oil" is a commercial name, and according to the botanically correct definition, it should be called Melaleuca alternifolia oil, because it is mainly derived from the number of Melaleuca L in the family Myrtaceae (Myrtaceae). species of plants, the most important one is called Melaleuca alternifolia, and the secondary plants are Melaleuca bracteata, Melaleuca ericifolia, Melaleuca (Melaleuca quinquenervia), Niaouli (Melaleuca Viridiflora), etc. Fresh leaves of Melaleuca alternifolia can be steam distilled to obtain a colorless to pale yellow essential oil with a warm, spicy aroma with aromatic terpenoids. At present, Australia produces about 500 tons of tea tree oil annually, almost all of which come from artificially cultivat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/97A61K8/11A61Q5/12A61P31/04
Inventor 李忠军陈锡其郑华生
Owner GUANGDONG FOOD & DRUG VOCATIONAL COLLEGE
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