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Manufacturing method of 8% flavomycin premixing agent

A manufacturing method and flavomycin technology, applied in chemical instruments and methods, preparation of sugar derivatives, additional food elements, etc., can solve the problems of inability to meet market demand, large product loss, long cycle, etc., to alleviate the contradiction between market supply and demand , The effect of energy saving and consumption reduction, the effect of material quality assurance

Active Publication Date: 2013-10-02
新疆上昵生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the difference in the level of fermentation, the dry matter content in the fermented liquid is usually above 10%, so the fermented liquid with a fermentation unit of less than 8000u / ml adopts the direct spray drying process to produce a product with a content of less than 8%, which cannot meet the market demand
At the same time, the product loss, high energy consumption, long cycle and low yield of fermentation broth produced by direct spray drying process

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A kind of 8% flavomycin premix preparation method comprises the following steps:

[0019] (1) Fermentation broth pretreatment

[0020] Flavomycin fermentation broth 5200L, fermentation unit 6806u / ml, dry matter content of fermentation broth 10.17%, containing flavomycin 35.39kg; after fermentation, adjust the pH of the fermentation broth to 7.5-8.5 with soda ash, turn on steam and heat to 80 ±2°C, during the heating process, measure the pH value every 10-15 minutes, and add soda ash to control the pH of the fermentation broth to 7.5-8.5, keep it warm for 30 minutes, and then cool down to below 30°C;

[0021] (2) Plate and frame filter

[0022] The fermented liquid after pretreatment was filtered by plate and frame to obtain 3975L of filtrate, the content of flavomycin was 6812u / ml, and the content of flavomycin in the filtrate was 27.08 kg; 1182 kg of wet bacteria were obtained, and the content of flavomycin was 6800u / g. The body contains 8.04kg of flavomycin, and the...

Embodiment 2

[0035] A kind of 8% flavomycin premix preparation method comprises the following steps:

[0036] (1) Fermentation broth pretreatment

[0037] Flavomycin fermentation broth 5200L, fermentation unit 9600u / ml, dry matter content of fermentation broth 10.21%, containing flavomycin 49.92kg; after fermentation, adjust the pH of the fermentation broth to 7.5-8.5 with soda ash, turn on steam and heat to 80 ±2°C, on the way of heating, measure the pH value every 10-15 minutes, and add soda ash in small quantities several times to control the pH of the fermentation broth to 7.5-8.5, keep it warm for 30 minutes, and then cool down to below 30°C;

[0038] (2) Plate and frame filter

[0039] The fermented liquid after pretreatment was filtered by plate and frame to obtain 4086L of filtrate, the content of flavomycin was 9550u / ml, and the content of flavomycin in the filtrate was 39.02kg; 1040kg of wet bacteria was obtained, and the content of flavinmycin was 9802u / g. The body contains 10...

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PUM

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Abstract

The invention discloses a manufacturing method of an 8% flavomycin premixing agent. The manufacturing method comprises the following steps of: pre-treating fermentation liquid, carrying out sheet frame filtering, concentrating filtering liquid, spraying and drying concentrated liquid, sieving, preparing and mixing to prepare the flavomycin premixing agent with the content of 8%. According to the manufacturing method disclosed by the invention, the 8% flavomycin premixing agent can be manufactured by using low-unit fermenting liquid so as to relieve a market imbalance between supply and demand; and the manufacturing method has the advantages of obvious energy-saving and consumption-reducing effect, shortened production period and improvement of production efficiency. The storage time of the fermenting liquid is shortened so that the quality of materials is guaranteed and the product yield and the product quality are improved.

Description

technical field [0001] The invention relates to the technology of fermented liquid filtration, filtrate concentration, spray drying and compound production of 8% flavomycin premix, which belongs to the field of biotechnology. Background technique [0002] Flavomycin, also known as banbermycin, yellow phospholipid, is a phosphopolysaccharide antibiotic, mainly derived from the fermentation product of Streptomyces banberii. Flavomycin has strong antibacterial effect on Gram-positive bacteria (including Gram-positive bacteria resistant to other antibiotics), and also has antibacterial effect on some Gram-negative bacteria, and has no cross-resistance with currently used antibiotics It has obvious growth-promoting effect and is widely used as a growth promoter for livestock and poultry. Flavomycin has a large molecular weight, is not absorbed by the digestive tract when taken orally, has low toxicity, no side effects, and no teratogenic effects. It is considered to be the most ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H1/06A23K1/17A23K20/195
Inventor 陈剑慧韩勤更朱菊芬沈敏祥杨锐周劲沈春梅
Owner 新疆上昵生物科技有限公司
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