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Application for ferulic acid in preparation for medicine used for relieving uterine bleeding after abortion

A technique of uterine bleeding and ferulic acid, applied in the direction of drug combination, sexual diseases, etc., to achieve the effect of reducing the amount of uterine bleeding

Inactive Publication Date: 2013-03-13
INST OF BASIC MEDICINE OF SAMS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ferulic acid has many functions, such as anti-oxidation, antithrombotic, blood lipid lowering, prevention and treatment of coronary heart disease, antibacterial and anti-inflammation, anti-mutation, anti-cancer, etc. It is widely used in food, medicine, cosmetics and other fields, but there is no ferulic acid It has the effect of reducing uterine bleeding after abortion

Method used

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  • Application for ferulic acid in preparation for medicine used for relieving uterine bleeding after abortion
  • Application for ferulic acid in preparation for medicine used for relieving uterine bleeding after abortion

Examples

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Embodiment Construction

[0041] The present invention will be further described below.

[0042] Take 130 g of commercially available pure ferulic acid, add 115 g of starch and 5 g of talcum powder, and press into tablets to make 1000 tablets, wherein the average weight of plain tablets is 0.25 g / tablet.

[0043] The present invention can also add pharmaceutically suitable auxiliary materials to prepare oral liquids, injections, capsules, granules, dripping pills, sustained and controlled release preparations and other pharmaceutical dosage forms.

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Abstract

The invention relates to a novel use of ferulic acid, and particularly relates to a novel use of ferulic acid in preparation for a medicine used for relieving uterine bleeding after abortion, wherein ferulic acid can be used for dominantly inducing the protein expressions of the specific nuclear transcription factors of subgroups Th1 and Th17 on the maternal-fetal interface of a mouse which is subjected to medical abortion via mifepristone, reducing the protein expressions of the specific nuclear transcription factors of subgroups Th2 and Treg, and then inducing the migration of T-cells to the subgroups Th1 and Th17 and promoting maternal-fetal immunological rejection, thus reducing the amount of the uterine bleeding of the mouse which is subjected to medical abortion.

Description

technical field [0001] The invention relates to a new application of ferulic acid, in particular to a new application of ferulic acid in preparing medicines for alleviating post-abortion uterine bleeding. Background technique [0002] Abnormal uterine bleeding after medical abortion seriously damages the physical and mental health of patients, affects the acceptance of medical abortion to a certain extent, and affects the smooth implementation of the national family planning policy. The existing treatment methods for abnormal uterine bleeding after medical abortion mainly include uterine curettage and mifepristone dosage optimization, but uterine curettage has the risk of infection, perforation, pain and other complications caused by uterine cavity operation, while the existing mifepristone The ketone dosage optimization scheme has the disadvantages of unstable curative effect. Therefore, it will be of great clinical value and social significance to find a method and drug f...

Claims

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Application Information

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IPC IPC(8): A61K31/192A61P15/00
Inventor 李霞王彬姚成芳王丽周宪宾郭钰琪赵向忠张巧凤姜国胜
Owner INST OF BASIC MEDICINE OF SAMS
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