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Preparation method of escitalopram oxalate impurity C

A technology of fluorophenyl and dimethylamino, applied in the field of preparation of escitalopram oxalate impurity C

Inactive Publication Date: 2013-03-06
BEIJING VENTUREPHARM BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

For the preparation method of this impurity, there is no relevant report

Method used

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  • Preparation method of escitalopram oxalate impurity C

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Embodiment 1

[0017] CH2), 2.12 (S, 6H, CH3), 2.26 ~ 2.25 (m, CH2), 1.45 ~ 1.43 (m, 1H, CH2), 1.29 ~ 1.22 (m, 2H, CH2).

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Abstract

The invention belongs to the technical field of medicine and in particular relates to a synthetic method of a 1-(3-(dimethylamino)propyl)-1-(4'-fluorophenyl)-3-oxo-1,3-dihydroisobenzofuran nitrile compound.

Description

Technical field [0001] The present invention disclosed compounds 1- [3- (甲 本 本) propylene] -1- (4’-fluorophenyl) -3-oxygen-1, 3-dihydrous ben bean. Background technique [0002] Escitaloplam (ETP (ETP, also known as ETP, also known as Azicic acid Plan) is currently the most selective antidepressant of 5-hydroxylin re-intake inhibitors., It is the right rotor of Xili Pulan (no activity of the Lobe). Its antidepressant effect is better than Xilu Pulan. It has fast results, small dosage, good tolerance, small adverse reactions, less drug interaction, etc.advantage.It is one of the ideal medicines for antidepressants. [0003] The structural format of the oxalic acid Yidi Proton is shown below: [0004] For the quality standards of the drug, it is mentioned in USP2.0, which is mentioned in the control of an impurities C. The name of the compound is (S) -1- [3- (dizen amin) propyl] -1- (4'-fluorophenyl) -3-oxygen-1, 3-dihydrous benzene, the structure is as follows: [0005] In order t...

Claims

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Application Information

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IPC IPC(8): C07D307/88
Inventor 蒋令伟郭夏宋雪梅
Owner BEIJING VENTUREPHARM BIOTECH
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