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Application of ethanol in drug treating acute decompression sickness

A technology for decompression sickness and medicine, which is applied in the application field of ethanol in the preparation of medicines for treating acute decompression sickness, can solve the problems of structural damage and difficulty, and achieves the effects of convenient storage, low price and convenient acquisition.

Inactive Publication Date: 2013-03-06
SHANGHAI SIXTH PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The most severe structural damage will occur within these 6 hours, and it will be difficult to recover if the treatment time window is missed

Method used

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  • Application of ethanol in drug treating acute decompression sickness

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Experimental drug: prepare a volume concentration of 25% ethanol aqueous solution, and prepare it into an injection preparation.

[0020] 1. Experimental animals and grouping: 32 healthy male New Zealand rabbits (purchased from Shanghai Baomu Experimental Animal Farm, ordinary grade, certificate number 04-0007), body weight 2~3kg. The New Zealand rabbits were randomly divided into treatment group and control group, 16 in each group.

[0021] 2. Experimental method: After duplicating all New Zealand rabbits into ADCS animal models, after in vivo fistula or dissection, the air bubbles existing in the posterior vena cava, aorta, coronary artery, subcutaneous blood vessels, and spinal cord that flow with blood can be directly observed. 16 rabbits in the treatment group were injected with 25% ethanol solution (3ml / kg) through the marginal ear vein, and 16 rabbits in the control group were injected with 10ml normal saline through the marginal ear vein, and the ebb and flow ...

Embodiment 2

[0026] Experimental drug: in 100 ~ 150ml of 52 ° liquor solution, add an equal volume of 5% glucose solution to make oral preparations.

[0027] 1. Objects: 12 ADCS patients encountered in the diving site of the coastal fishery base, all of them were divers and male. Aged 18~58 years old, diving experience 2~19 years.

[0028] 2. Experimental method: 12 ADCS patients dived into water with a depth of 27-48 meters, the diving time was 28-185 minutes, and the number of diving was 1-3 times. No decompression was performed after the underwater operation, and they swam to the surface within 2 to 5 minutes. Six to 12 minutes after immersion, ADCS symptoms and signs appeared, manifested as shortness of breath, skin itching, severe pain in the large joints of the extremities, marbled abdominal skin, and non-injurious movement disorders of different degrees and parts. Ultrasonic Doppler blood flow detection instrument was used for inspection, and the probe was placed in the third an...

Embodiment 3

[0033] Experimental drug: in 100ml of 52 ° liquor solution, add equal volume of 5% glucose solution to make oral preparation.

[0034]Patient Wang ××, male, 38 years old, a fishery diver with 19 years of diving experience. Underwater salvage of sea treasures, the diving depth is about 30 meters, the diving time is 185 minutes, and the water can be released quickly within 2 minutes without decompression. Ten minutes after getting out of the water, there was tingling pain in the left joint, which gradually got worse, so that she couldn't move. Twenty-five minutes after getting out of the water, the right knee joint was stabbing, and it was bent when standing. It was difficult to stand, squat, and walk. The Doppler bubble sound measured in the pulmonary artery area was grade Ⅲ. 28 minutes after the onset of symptoms, drink 200ml of 52° liquor diluted with an equal volume of 5% glucose solution within 7 minutes. 15 to 20 minutes after drinking, the tingling pain in both knees, w...

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Abstract

The invention discloses application of ethanol in a drug treating acute decompression sickness (ADCS). An ethanol solution is prepared first, and then the ethanol solution is prepared into the drug treating acute decompression sickness. The drug treating acute decompression sickness provided in the invention can reduce the surface tension of bubbles, promote bubble breakage, increase respiratory frequency, is in favor of discharging the nitrogen dissolved from the bubbles out of the body through breathing, can enhance myocardial contractility, dilate blood vessels significantly, and accelerate blood circulation, thus counteracting the pathological changes of vasospasm and blood stasis brought by decompression sickness. The powerful lipid solubility and permeability of ethanol enable it to rapidly enter a blood brain barrier and enter brain and spinal cord tissues so as to eliminate central nervous complications of ADCS.

Description

technical field [0001] The invention relates to a new medicinal application of ethanol, in particular to the application of ethanol in the preparation of medicines for treating acute decompression sickness. Background technique [0002] Acute decompression sickness (ADCS for short) is an occupational disease that seriously threatens the lives of workers in high-pressure environments such as diving, caissons, and tunnels. The pathogenesis of ADCS is due to improper or too fast decompression, resulting in the release of supersaturated inert gas dissolved in blood or body fluids in a high-pressure environment, forming air bubbles to block or compress blood vessels, resulting in pathological changes such as vasospasm and blood stasis. Acute ischemic and hypoxic damage occurs to the tissues and organs supplied by the blood. [0003] Domestic and foreign medical circles have been using recompression as an effective method for the treatment of ADCS. Recompression therapy is to re...

Claims

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Application Information

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IPC IPC(8): A61K31/045A61P43/00
Inventor 傅敏张陆弟康建飞张锦程
Owner SHANGHAI SIXTH PEOPLES HOSPITAL
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