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PLA absorbable bone screw with PBC as toughening agent, and preparation method thereof

A technology of toughening agent and bone nail, which is applied in the application field of biomedical materials, can solve the problems of high brittleness, poor toughness, PLA is not suitable for degradable bone nails, etc., and achieves low manufacturing cost, short process and good preparation method simple effect

Inactive Publication Date: 2013-02-20
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the PLA material also has an Achilles heel, that is, it is too brittle, that is, its toughness is not good. This shortcoming makes PLA not suitable for the preparation of degradable bone screws, and must be modified to improve its toughness.

Method used

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  • PLA absorbable bone screw with PBC as toughening agent, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] (1) Take a certain amount of PBC, PLA, and HAP, and dry them at a certain temperature and time to remove moisture. Among them, the weight ratio of PLA is 95%, the drying temperature is 100°C, and the drying time is 8 hours; the weight ratio of PBC is 4.5%, the drying temperature is 50°C, and the drying time is 8 hours; the weight ratio of HAP is 0.5%, and the drying temperature is 8 hours. 120°C, drying time 8 hours.

[0024] (2) Blend the dried PBC, PLA, and HAP in a twin-screw blender at a temperature of 190°C, and then inject them into a mold to form a cylindrical PBC / PLA / HAP with a diameter of 1.8mm Compound splines.

[0025] (3) Place the composite spline in a material stretching machine for stretching, the temperature of the heating air is 120°C, and the stretching ratio is 2.5 times.

[0026] (4) Cut the stretched spline to make a screw with a diameter of 1 mm to obtain the desired degradable bone nail.

Embodiment 2

[0028] (1) Take a certain amount of PBC, PLA, and HAP, and dry them at a certain temperature and time to remove moisture. The weight ratio of PLA is 90%, the drying temperature is 100°C, and the drying time is 8 hours; the weight ratio of PBC is 9%, the drying temperature is 50°C, and the drying time is 8 hours; the weight ratio of HAP is 1%, and the drying temperature is 8 hours. 120°C, drying time 8 hours.

[0029] (2) Blend the dried PBC, PLA, and HAP in a twin-screw blender at a temperature of 180°C, and then inject them into a mold to form a cylindrical PBC / PLA / HAP with a diameter of 2.8mm Compound splines.

[0030] (3) Place the composite spline in a material stretching machine for stretching, the temperature of the heating air is 100°C, and the stretching ratio is 5 times.

[0031] (4) Cut the stretched spline to make a screw with a diameter of 1.2 mm to obtain the desired degradable bone nail.

Embodiment 3

[0033] (1) Take a certain amount of PBC, PLA, and HAP, and dry them at a certain temperature and time to remove moisture. The weight ratio of PLA is 85%, the drying temperature is 100°C, and the drying time is 8 hours; the weight ratio of PBC is 12%, the drying temperature is 50°C, and the drying time is 8 hours; the weight ratio of HAP is 3%, and the drying temperature is 8 hours. 120°C, drying time 8 hours.

[0034] (2) Blend the dried PBC, PLA, and HAP in a twin-screw blender at a temperature of 170°C, and then inject them into a mold to form a cylindrical PBC / PLA / HAP compound with a diameter of 12mm. module.

[0035] (3) Place the composite spline in a material stretching machine for stretching, the temperature of the heating air is 60°C, and the stretching ratio is 3.5 times.

[0036] (4) Cut the stretched spline to make a screw with a diameter of 6 mm to obtain the desired degradable bone nail.

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Abstract

The invention relates to a PLA absorbable bone screw with PBC as a toughening agent, and a preparation method thereof. The bone screw is a screw prepared from a composite material, wherein the composite material is a blend of a substrate material PLA, a toughening agent PBC, and an additive HAP. The preparation method comprises the steps that: (1) PBC, PLA, and HAP are respectively bake-dried, such that water content is removed; (2) the dried PBC, PLA, and HAP are heated and blended according to a certain ratio; and a cylindrical PBC / PLA / HAP composite sample bar is obtained by injection molding; (3) the composite sample bar is stretched under hot air; and (4) the stretched sample bar is subjected to cutting machining, such that a screw is prepared, wherein the screw is the PLA absorbable bone screw with PBC as the toughening agent. The bone screw provided by the invention has excellent mechanical performances and good biocompatibility, such that re-injury to patient caused by secondary operation is avoided. The degradation product of the product provided by the invention causes no toxicity or harm. The preparation method is simple and is suitable for industrialized productions.

Description

technical field [0001] The invention belongs to the application field of biomedical materials, in particular to a PLA absorbable bone nail with PBC as a toughening agent and a preparation method thereof. Background technique [0002] The global population is aging rapidly. According to the forecast of the United Nations Population Fund, in the next five years, the number of people aged 65 and above will exceed the number of children under the age of five for the first time in human history, and the population changes in developing countries will be particularly significant. Figures provided by the World Health Organization show that since 1980, the number of people aged 60 and over has doubled; by 2050, the number of people aged 80 and over will nearly quadruple to 395 million. China is expected to enter an "aging society" in 2026-2027. The number of elderly people in China ranks first in the world. [When the world is "getting old" - 2012 World Health Day focuses on "agin...

Claims

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Application Information

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IPC IPC(8): A61L31/14A61L31/06A61L31/02
Inventor 杨庆刘馨洋郯志清沈新元吴文华吉亚丽
Owner DONGHUA UNIV
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