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Method for preparing microspheres through oil in nano-particle suspension-oil in oil-water in oil

A nanoparticle and suspension technology, used in powder delivery, bulk delivery, etc., can solve the problems of low encapsulation rate, local microencapsulation and inflammation, reduce inflammation and microencapsulation, and avoid degeneration and inactivation. , enhance the effect of cell adhesion

Inactive Publication Date: 2014-12-10
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a nanoparticle suspension oil-in-oil-water-in-oil method for preparing microspheres, to solve the problem of low encapsulation efficiency of microsphere preparations in the prior art and local microspheres caused by hydrophobic surfaces. Disadvantages of cystization and inflammation

Method used

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  • Method for preparing microspheres through oil in nano-particle suspension-oil in oil-water in oil
  • Method for preparing microspheres through oil in nano-particle suspension-oil in oil-water in oil
  • Method for preparing microspheres through oil in nano-particle suspension-oil in oil-water in oil

Examples

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Effect test

Embodiment 1

[0047] Example 1 Small molecule drug microspheres taking doxorubicin as an example

example 1

[0048] Example 1: The preparation of polylactic-glycolic acid (PLGA) microspheres loaded with an aqueous solution of doxorubicin with antibacterial and anticancer effects comprises the following steps:

[0049] (1) Dissolve 20mg of doxorubicin in 0.5ml of water to form an aqueous drug solution;

[0050] (2) Mix the above-mentioned aqueous solution of the drug with a dichloromethane solution of 20% PLGA according to a weight ratio of 1:9 and ultrasonicate for 5 minutes to form a uniform suspension, that is, a water-in-oil (W / O) emulsion;

[0051] (3) Add the water-in-oil (W / O) emulsion obtained in step (2) dropwise into 5ml of hydrophilic oil phase ethylene glycol and stir for 5 minutes to form an oil-in-oil-water-in-oil (W / O / O) complex milk;

[0052] (4) the oil-in-oil-water-in-oil (W / O / O) double emulsion that step (3) gained is added dropwise to 50ml weight percent concentration and is in the silver nanoparticle suspension of 10% and stirs 5 minutes to form nanoparticle Sus...

example 2

[0059] Example 2: Preparation of polylactic-glycolic acid (PLGA) microspheres loaded with an aqueous solution of doxorubicin with antibacterial and anticancer effects

[0060] The difference between this example 2 and example 1 is that in step (4), the oil-in-oil-water-in-oil (W / O / O) double emulsion obtained in step (3) is added dropwise to silver nanoparticles containing 10% and 1% (w / w) PVA surfactant in suspension.

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Abstract

The invention discloses a method for preparing microspheres through oil in nano-particle suspension-oil in oil-water in oil (W / O / O / S) and belongs to the technical field of pharmacy. The method includes adding medicine aqueous solution to a polymer organic solution for emulsification to obtain an emulsion, adding the emulsion into a hydrophilic oil phase, stirring, mixing, choosing the nano-particle suspension to serve as a surface active agent ball, finally performing hardening in another large aqueous phase, removing the organic solvent, and collecting the microspheres. The prepared microspheres comprise, by weight, 0.1%-40% of medicines, 9.9%-96% of nano-particles, 90%-3.65% of polymers and 0-30% of pharmaceutic adjuvants. According to the method for preparing the microspheres through oil in nano-particle suspension-oil in oil-water in oil (W / O / O / S), the problem of poor tissue compatibility caused by the fact that the microspheres are prepared through conventional methods of water in oil (W / O), water in oil in water (W / O / W) and solid in oil in oil (S / O / O) is solved, the surfaces of the prepared microspheres are assembled with the nano-particles, the prepared microspheres have effect of enhancing cell adhesion, inflammation and microencapsulation caused by local peracid and a hydrophobic material can be reduced, and the method can be applied to preparation of various medicine sustained-release or controlled-release microspheres and treatment of diseases.

Description

technical field [0001] The invention relates to microspheres in the technical field of pharmacy and a preparation method thereof, in particular to a method for preparing microspheres by nanoparticle suspension oil-in-oil-water-in-oil (W / O / O / S). Background technique [0002] In the pharmaceutical industry, from drug discovery to clinical application, the last link is drug preparation. Some of the drugs need long-term administration to be cured; others need targeted and other local administration. To achieve these goals, raw materials must be prepared into corresponding dosage forms. For example, drugs that require long-term administration but have a short half-life in the body should be prepared as sustained-release long-acting dosage forms; for the treatment of some tumors, some drugs need to be targeted to the disease, such as embolization microsphere preparations that target tumor blood vessels, etc. . [0003] Regarding the preparation method of microsphere preparation...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K9/16A61K47/34A61K47/38
Inventor 袁伟恩金拓吴飞洪晓芸张奇昕徐建雄
Owner SHANGHAI JIAO TONG UNIV
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