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Formulation and preparation method of antibacterial spray

A spray, chitosan technology, applied in the direction of antifungal agents, medical preparations containing active ingredients, antibacterial drugs, etc., can solve problems such as unsatisfactory sterilization effect

Inactive Publication Date: 2013-01-02
TIANJIN POLYTECHNIC UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although chitosan has a certain bactericidal function, its bactericidal effect is not ideal

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Take 0.6g of carboxymethyl chitosan into a 1L beaker, add 300mL of water to swell, and let it stand still. If it does not dissolve, add dilute acetic acid dropwise, stir while adding dropwise until dissolved, and let stand for 1h. Another 5 g of polyhexamethylene guanidine was dissolved in water. Add the polyhexamethylene guanidine solution into the chitosan solution and mix evenly, then add glycerin and vitamin E to mix in an appropriate amount, add water to make up the volume, stir evenly, fill and sterilize by radiation.

Embodiment 2

[0019] Take 0.3g of carboxymethyl chitosan into a 1L beaker, add 300mL of water to swell, and let it stand still. If it does not dissolve, add dilute acetic acid dropwise, stir while adding dropwise until dissolved, and let stand for 1h. Another 8 g of polyhexamethylene guanidine was dissolved in water. Add the polyhexamethylene guanidine solution into the chitosan solution and mix evenly, then add glycerin and vitamin E to mix in an appropriate amount, add water to make up the volume, stir evenly, fill and sterilize by radiation.

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PUM

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Abstract

The invention discloses a formulation and a preparation method of an antibacterial spray with antibacterial, hemostasis and promotion of wound healing effects. The spray contains water which is used as a solvent, and chitosan, glycerol, polyhexamethylene guanidine and vitamin E which are used as main effective components. The antibacterial spray has obvious activity inhibition on growth of multiple types of pathogenic bacteria, the killing rate of the antibacterial spray on staphylococcus aureus, escherichia coli and candida albicans can reach 99%, and the antibacterial spray does not stimulate skins and mucosa, is suitable for treating skin and mucosa wound surface infection, and can be used for promoting the wound healing.

Description

technical field [0001] The invention relates to a formulation and preparation method of an antibacterial spray with antibacterial, hemostatic and capable of promoting wound healing. The spray uses water as a solvent and mainly uses chitosan, glycerin, polyhexamethylene guanidine, and vitamin E. Active ingredients. The invention has obvious inhibitory activity on the growth of various pathogenic bacteria, and the killing rate on Staphylococcus aureus, Escherichia coli and Candida albicans can reach 99%. It is non-irritating to the skin and mucous membrane, and is suitable for the treatment of wound infection of the skin and mucous membrane, and can promote wound healing. technical background [0002] Trauma is one of the most common diseases in daily life, mainly including skin and mucous membrane wound injuries. The methods for treating wounds on the market mainly include powdered medicines, band-aids, ointment medicines and liquid auxiliary materials. The irritation of t...

Claims

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Application Information

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IPC IPC(8): A61K31/785A61K31/722A61K31/737A61P31/04A61P31/10A61P17/02A61P7/04
CPCY02A50/30
Inventor 郭文娟范敏付文娟
Owner TIANJIN POLYTECHNIC UNIV
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