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Skin hyperpigmentation acyl glutathione treatments

A technology of acyl glutathione and skin whitening, which is applied in skin diseases, skin care preparations, tripeptide components, etc., and can solve the problems of cysteine ​​utilization rate limitation and glutathione synthesis limitation

Inactive Publication Date: 2012-12-26
N V PERRICONE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

They themselves limit further glutathione synthesis due to elevated glutathione levels; additionally, cysteine ​​availability is often rate-limiting

Method used

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  • Skin hyperpigmentation acyl glutathione treatments
  • Skin hyperpigmentation acyl glutathione treatments
  • Skin hyperpigmentation acyl glutathione treatments

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0069] Formulation: An oil-in-water emulsion formulation was prepared by combining the following ingredients using conventional mixing techniques.

[0070] raw material

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Abstract

Topical compositions for treatment of hyperpigmentation comprise an effective amount of S-acyl glutathione derivative and a carrier. Methods for treating hyperpigmentation, such as melasma, postinflammatory hyperpigmentation and lentigines, skin lightening and skin whitening comprise applying a composition containing S-acyl glutathione derivative in a dermatologically acceptable carrier to skin tissue. The acyl group is a saturated or unsaturated aliphatic C12-C24 group, preferably a C16-C24 group, most preferably a C16 group. In particularly preferred embodiments, the S-acyl glutathione derivative is S-palmitoyl glutathione.

Description

field of invention [0001] The present invention relates to topical compositions comprising glutathione derivatives. More specifically, the present invention relates to topical compositions comprising glutathione acyl derivatives for skin lightening, skin lightening and treatment of skin hyperpigmentation. Background of the invention [0002] Reduced glutathione, commonly referred to as glutathione or GSH, is a relatively small molecule found in plants and animals with the following formula: [0003] [0004] Glutathione is an orthomolecule in water. It is the smallest intracellular thiol molecule. Due to its remarkable electron-donating ability, it is an effective reducing compound. Glutathione is a potent antioxidant and enzyme cofactor that plays an important role in regulating cellular activity. [0005] Glutathione is a chain tripeptide of L-glutamine, L-cysteine ​​and glycine. Academically, N-L-γ-glutamyl-cysteinylglycine or L-glutathione, the molecule has a sul...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61Q19/02
CPCA61K8/676A61K8/678A61K8/64A61K8/4986A61K8/365A61Q19/08A61Q19/02A61P17/00A61K38/06
Inventor N.V.佩里科恩
Owner N V PERRICONE
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