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Application of disaccharide compound in preparing anti-tumor medicine

A compound and drug technology, applied in the field of use of disaccharide compounds in the preparation of antitumor drugs, to achieve obvious anti-influenza virus effect, enhance immunity, and improve the effect of quality of life

Inactive Publication Date: 2013-09-04
LUZHOU MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] This compound was first found in Rhodiola angustifolia. At present, only the extraction method of this compound has been reported in the literature [Helmut Wiedenfeld, Monika Zych, Waldemar, et al. New compounds from Rhodiola kirilowii. Scientia Pharmaceutica.75,29-34( 2007)], there is no relevant report on the pharmacodynamic effect of this disaccharide compound

Method used

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  • Application of disaccharide compound in preparing anti-tumor medicine
  • Application of disaccharide compound in preparing anti-tumor medicine
  • Application of disaccharide compound in preparing anti-tumor medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1 The preparation method of formula 1 compound of the present invention

[0026] 10kg of coarse powder of Radix isatidis, soaked in 50% ethanol for 1 hour, and refluxed for 3 times, 1 hour each time. The extracts were combined, ethanol was recovered under reduced pressure until there was no alcohol smell, vacuum-dried at 50°C, and pulverized to obtain 1560 g of dry extract powder of the crude extract, with a yield of 15.6%. Take 500g of dry extract powder of the crude extract and reflux with 95% ethanol for 3 times, 1 hour each time, filter, combine the extracts, recover the ethanol under reduced pressure until there is no alcohol smell, dry in vacuum at 50°C, and crush to obtain Radix Radix dry infusion Paste powder 168g, yield is 5.2%.

[0027] Take the above dry extract powder of Radix isatidis and separate it by silica gel column dry column chromatography, dichloromethane-methanol (100:0-1:1) gradient elution, check according to thin-layer chromatography...

Embodiment 2

[0034] Embodiment 2 Preparation of the pharmaceutical composition of the present invention

[0035] Take the compound of formula 1 prepared in Example 1, mix evenly with an appropriate amount of microcrystalline cellulose, and directly pack into capsules to obtain the capsules of the pharmaceutical composition of the present invention.

Embodiment 3

[0036] Embodiment 3 Preparation of the pharmaceutical composition of the present invention

[0037] Take the compound of formula 1 prepared in Example 1, mix it uniformly with appropriate amount of sucrose and starch, use 80% ethanol as a binder, and granulate it to obtain the pharmaceutical composition granules of the present invention.

[0038] The beneficial effect of the compound of formula 1 is demonstrated by specific test examples below.

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Abstract

The invention provides application of a disaccharide compound shown by the formula 1 in preparing an anti-tumor medicine. In the invention, the structure of the compound of the formula 1 is similar to that of sucrose, and the compound is a simple disaccharide compound; after entering the body, the compound shows relatively strong biological activity, can effectively suppress the tumor growth, and realizes an obvious anti-tumor effect; the compound can enhance the immunity of normal organisms as well as organisms suffering cancers; and when in chemical therapy, the compound can improve the immunologic function of patients in chemical therapy so as to improve the quality of life of the patients suffering cancers.

Description

[0001] This application is a divisional application of the patent application with application number: 201110306878.4. The application number of the original application: 201110306878.4, the application date: October 11, 2011, the title of the invention: a new use of a disaccharide compound. technical field [0002] The invention relates to a new application of a disaccharide compound in the preparation of antitumor drugs. Background technique [0003] Disaccharides are formed by two molecules of monosaccharides through glycosidic bonds. After hydrolysis, two monosaccharide molecules can be formed. Naturally occurring free and functional sugars are represented by lactose in mammals, trehalose in bacteria and insect blood, and plant sucrose. They are used as energy sources for various organisms, or as raw materials for organisms. [0004] Common disaccharides include lactose, maltose, and sucrose. Among them, sucrose is formed from a molecule of glucose and a molecule of fru...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7016A61P35/00A61P37/04
Inventor 孙琴陈斯玮欧丽兰刘明华税丕先张诗静罗颖
Owner LUZHOU MEDICAL COLLEGE
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