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Hepatocellular carcinoma-related klotho gene single-nucleotide polymorphism and its construction method and use

A single nucleotide polymorphism, hepatocellular carcinoma technology, applied in biochemical equipment and methods, microbial determination/test, DNA/RNA fragments, etc., can solve problems such as susceptibility to hepatocellular carcinoma

Inactive Publication Date: 2012-11-28
黄曙 +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] After searching domestic and foreign literature and patents of the prior art, there is no related report on the relationship between klotho gene polymorphism and susceptibility to hepatocellular carcinoma

Method used

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  • Hepatocellular carcinoma-related klotho gene single-nucleotide polymorphism and its construction method and use
  • Hepatocellular carcinoma-related klotho gene single-nucleotide polymorphism and its construction method and use
  • Hepatocellular carcinoma-related klotho gene single-nucleotide polymorphism and its construction method and use

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Embodiment 1

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[0045] OrganizationName : The Second Affiliated Hospital of Nanjing Medical University

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[0064] Title : A single nucleotide polymorphism of klotho gene associated with prima...

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Abstract

The invention provides hepatocellular carcinoma-related klotho gene single-nucleotide polymorphism and its construction method and use. The hepatocellular carcinoma-related klotho gene single-nucleotide polymorphism and its construction method have the advantages that 1, through a detection method provided by the invention, polymorphism of a single nucleotide located in an exon 4 area of a human klotho gene can be detected fast and simply and it is diagnosed that if an individual has susceptibility of hepatocellular carcinoma so that the hepatocellular carcinoma-susceptible population screening and hepatocellular carcinoma prevention are promoted; 2, a T allele point of rs648202 is used as a drug design target point for drug screening so that an active molecule adjusting a klotho gene expression level is selected and development of a novel antitumor drug is promoted; 3, through primer sequences and HaeIII endonuclease provided by the invention, simple, efficient and specific detection of rs648202 polymorphism is realized; and 4, according to hepatocellular carcinoma-related klotho gene single-nucleotide polymorphism, a hepatocellular carcinoma genetic diagnosis kit can be constructed.

Description

Technical field [0001] The present invention provides a Klotho gene monocycopide polymorphism polymorphism and its application related to primary liver cell cancer, which belongs to the field of genetic engineering biotechnology. Background technique [0002] Primary liver cellular liver cancer (referred to as liver cancer, HCC) is one of the most common malignant tumors in the world. Data released by the American Cancer Society (ACS) in December 2007 showed that liver cancer increased by 667,000 per year and 598,000 deaths. For example, about 50%of new cases and death cases in China are in China, that is, liver cancer has a greater health threat to the people of our country, and has become the second tumor killer in my country. , Society brings serious economic and psychological burdens. [0003] Single nucleotide polymorphism (SNP) refers to polymorphism caused by the mutation of a single nucleotide at the genome level.It is the most common type of human genetic mutation, accou...

Claims

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Application Information

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IPC IPC(8): C12Q1/68C12N15/11
Inventor 黄曙季国忠杨昀范志宁王敏汤小伟
Owner 黄曙
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