Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

D-amino-acid oxidase inhibitor for preventing and/or reversing opioid tolerance

An oxidase inhibitor and amino acid technology, which can be used in anti-inflammatory agents, non-central analgesics, medical preparations containing active ingredients, etc., can solve the problems of limited application of opioid agonists and reduced pain relief

Inactive Publication Date: 2012-10-17
王永祥
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, repeated administration of an opioid agonist such as morphine leads to a gradual decrease in its analgesic effect and eventually leads to the development of tolerance to the analgesic effect of the opioid
For these reasons, despite their excellent efficacy, the use of opioid agonists such as morphine in the clinical field is limited

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • D-amino-acid oxidase inhibitor for preventing and/or reversing opioid tolerance
  • D-amino-acid oxidase inhibitor for preventing and/or reversing opioid tolerance
  • D-amino-acid oxidase inhibitor for preventing and/or reversing opioid tolerance

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0084] Effect of subcutaneous injection of DAO inhibitor CBIO on morphine tolerance in a single or consecutive 7 days

[0085] [82] Male Swiss mice (20-25g, Shanghai Slack Laboratory Animal Co., Ltd.) were free to drink and eat, and were divided into 10 groups, each with 4 mice. Three groups of mice were injected with saline (10ml / kg) subcutaneously twice a day for 7 consecutive days. On the 8th day, they were given saline (10ml / kg) and CBIO (10mg / kg, from Maybridge Chemicals, Cornwall, UK) ) Or morphine (5mg / kg, from Northeast Pharmaceutical Group Shenyang First Pharmaceutical Co., Ltd.); 2 groups of mice were injected subcutaneously with CBIO (10mg / kg) or morphine (10mg / kg) twice a day for 7 consecutive days, CBIO (10mg / kg) or morphine (5mg / kg) were given on the 8th day; the two groups of mice were injected subcutaneously with CBIO (10mg / kg) or morphine (10mg / kg) twice a day for 7 consecutive days. Morphine (5mg / kg) or CBIO (10mg / kg) were given on the same day; the two groups ...

Embodiment 2

[0087] Preventive effect of subcutaneous injection of D-amino acid oxidase inhibitor AS057278 and sodium benzoate on morphine tolerance for 7 consecutive days

[0088] [83] Male Swiss mice (20-25g, Shanghai Slack Laboratory Animal Co., Ltd.) were free to drink and eat. They were divided into 5 groups with 4 mice in each group. Two groups of mice were injected subcutaneously with normal saline (10ml / kg) twice a day for 7 consecutive days. On the 8th day, they were given normal saline (10ml / kg) or morphine (5mg / kg) respectively; the three groups of mice were injected subcutaneously respectively Morphine (10mg / kg), AS057278 (40mg / kg, from Sigma-Aldrich, St Louis, MO) + morphine (10mg / kg) or sodium benzoate (400mg / kg, from Sinopharm Group, Shanghai, China) + morphine (10mg / kg), twice a day for 7 consecutive days, morphine (5mg / kg) was given on the 8th day. 20 minutes after the administration on the 8th day, the mice were injected with 10μl 5% formalin on the right back of the foot t...

Embodiment 3

[0090] Intrathecal single injection of D-amino acid oxidase inhibitor CBIO (30μg), AS057278 (100μg), sodium benzoate (300μg) and reactive oxygen species (ROS) scavenger PBN (1mg) on ​​morphine tolerance influences

[0091] [84] Male Wistar rats (weight 150-170g, Shanghai Slack Laboratory Animal Co., Ltd.) were divided into 5 groups, each with 4 rats. Intrathecal injection of morphine (50μg / 10μl / rat) once a day for 5 consecutive days. The fifth injection was given with saline (10μl / rat), CBIO (30μg), AS057278 (100μg), sodium benzoate (300μg) ) And reactive oxygen species (ROS) scavenger PBN (1mg), morphine (5μg / 10 μl / rat) was given on the 6th day, 30 minutes later, the rats were injected with 50μl 5% formalin on the back of the right hind foot It causes pain. Observe the number of times the rat’s feet are lifted or shaken within 1 minute as an indicator of pain during 0-90 minutes after formalin injection. The experimental results are as image 3 As shown, rats were given signif...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a D-amino-acid oxidase inhibitor for preventing and / or reversing opioid tolerance and a method for preventing or reversing opioid tolerance by the use of the D-amino-acid oxidase inhibitor, and also provides a method for preventing and / or treating ache by the use of the D-amino-acid oxidase inhibitor and a method for identifying the compound for preventing and / or reversing opioid tolerance.

Description

Technical field [0001] [01] The present disclosure relates to the prevention and / or reversal of opioid tolerance. Specifically, D-amino acid oxidase inhibitors for preventing and / or reversing opioid tolerance are provided, and methods of using D-amino acid oxidase inhibitors to prevent and / or reversing opioid tolerance are also provided. D-amino acid oxidase is used to prevent and / or treat pain, and to identify compounds that prevent and / or reverse opioid tolerance. Background technique [0002] [02] Opioid receptor agonists (also known as opioid agonists, opioids, opioids and opioids) such as morphine are a class of narcotic analgesics, when relatively high doses or low doses but long-term repeated use At times, strong drug tolerance is produced, which leads to a decrease in the analgesic effect of analgesics. Therefore, narcotic analgesics should be used in increased doses in order to obtain the desired analgesic effect. The increase in the dose of this narcotic analgesic ca...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K45/06A61P25/04A61P25/06A61P29/00
CPCA61K31/192A61K31/485A61K31/00A61K31/423A61K45/00A61K31/407A61K45/06A61K31/4704A61K31/415A61P25/04A61P25/06A61P25/30A61P29/00A61K2300/00
Inventor 王永祥龚念黄金路
Owner 王永祥
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com