Antifungal pharmaceutic preparation for external use

A topical drug and antifungal technology, applied in the direction of antifungal agent, drug combination, aerosol delivery, etc., can solve the problems of incomplete sterilization, secondary infection, poor drug dependence of patients, etc., and achieve good anti-inflammatory and antipruritic effects , the effect of improving the cure rate

Inactive Publication Date: 2012-10-10
NANJING ZHENGKUAN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still some problems in the antifungal field, such as slow onset of action, incomplete sterilization, high recurrence rate, persistent healing, and many patients suffer
In addition, most fungal infections have itching problems, and some of them are accompanied by inflammation, which makes patients less dependent on medication and leads to secondary infections

Method used

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  • Antifungal pharmaceutic preparation for external use
  • Antifungal pharmaceutic preparation for external use
  • Antifungal pharmaceutic preparation for external use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The preparation of embodiment 1 compound ointment

[0020] Ointment Prescription:

[0021]

[0022] Preparation process: first heat stearic acid on a water bath to dissolve, then add liquid paraffin and heat to 75°C±2°C and keep it to form an oil phase; dissolve butenafine hydrochloride and cetylpyridinium chloride in 1,2-propylene glycol and deionized water, then add Tween 80 and preservative, stir well and heat to 75°C±2°C and keep it to form a water phase; finally, slowly add the oil phase to the water phase, stirring while adding, until condensation , to obtain an ointment.

Embodiment 2

[0023] The preparation of embodiment 2 compound ointment

[0024] Ointment Prescription:

[0025]

[0026] Preparation process: first heat and melt glycerol monostearate on a water bath, then add liquid paraffin and heat to 75°C±2°C and keep it to form an oil phase; dissolve butenafine hydrochloride and cetylpyridinium chloride in 1, 2-Propanediol and deionized water, then add Tween 80 and preservative, stir well and heat to 75°C±2°C and keep it to form a water phase; finally add the oil phase to the water phase slowly, stirring while adding until it condenses to obtain an ointment.

Embodiment 3

[0027] The preparation of embodiment 3 compound ointment

[0028] Ointment Prescription:

[0029]

[0030] Preparation process: first heat and melt glycerol monostearate on a water bath, then add liquid paraffin and heat to 75°C±2°C and keep it to form an oil phase; dissolve butenafine hydrochloride and cetylpyridinium chloride in 1, 2-Propanediol and deionized water, then add Tween 80 and preservative, stir well and heat to 75°C±2°C and keep it to form a water phase; finally add the oil phase to the water phase slowly, stirring while adding until it condenses to obtain an ointment.

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Abstract

The invention discloses an antifungal pharmaceutic preparation for external use. The antifungal pharmaceutic preparation consists of active ingredients and pharmaceutic adjuvants, wherein the active ingredients comprise butenafine hydrochloride and cetylpyridinium chloride, and preferably, the weight ratio of the butenafine hydrochloride to the cetylpyridinium chloride is (1.2-10):1. The antifungal pharmaceutic preparation disclosed by the invention is better in antifungal effect, low in recurrence rate and good in anti-inflammatory and antipruritic effect.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to an external pharmaceutical preparation for antifungal infection. Background technique [0002] Superficial skin fungal infectious diseases account for a high proportion of skin diseases, are generally easy to relapse, and are difficult to cure, and belong to one of the intractable skin diseases. Clinically common skin fungal infectious diseases include tinea manuum, tinea pedis, jock itch, tinea corporis, tinea capitis, etc. The symptoms are mainly manifested in local skin moist flushing, erosion, maceration and whitish or small blisters, unbearable itching of the skin, erysipelas and lymphangitis often caused by secondary infection after scratching, easy keratosis and desquamation after drying, chapped. Can be contagious, easy to relapse. The main causes of skin fungal infections are Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyto...

Claims

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Application Information

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IPC IPC(8): A61K31/4425A61K9/06A61P17/00A61P31/10A61K31/137
Inventor 不公告发明人
Owner NANJING ZHENGKUAN MEDICAL TECH
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