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Clindamycin phosphate solvate crystal and preparation method thereof

A clindamycin phosphate and solvate technology, which is applied in the field of clindamycin phosphate solvate crystals and its preparation, can solve problems such as poor stability of clindamycin phosphate

Active Publication Date: 2012-09-26
ZHUHAI EBANG PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The object of the present invention is to solve the defect of poor stability of clindamycin phosphate in the prior art, and provide a stable clindamycin phosphate solvate crystal and a preparation method thereof

Method used

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  • Clindamycin phosphate solvate crystal and preparation method thereof
  • Clindamycin phosphate solvate crystal and preparation method thereof
  • Clindamycin phosphate solvate crystal and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Embodiment 1 Preparation of clindamycin phosphate n-butanol-water solvate crystal

[0063] Dissolve 4.8g of clindamycin phosphate in a mixed solvent of 40ml of n-butanol and 10ml of water, heat and stir at 40-50°C for 0.5-1 hour to dissolve, filter, and the filtrate evaporates naturally at room temperature, and white blocky crystals appear after 7 days. That is, clindamycin phosphate n-butanol-water solvate crystals.

Embodiment 2

[0064] Embodiment 2 Preparation of clindamycin phosphate dimethyl sulfoxide-water solvate crystal

[0065] Dissolve 5.2g of clindamycin phosphate in a mixed solvent of 20ml of dimethyl sulfoxide and 20ml of water, heat and stir at 40-50°C for 0.5-1 hour to dissolve, filter, and the filtrate evaporates naturally at room temperature, and white needles appear after 7 days Clindamycin phosphate dimethyl sulfoxide-water solvate crystals.

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Abstract

The invention belongs to a medical technology field, more specifically relates to clindamycin phosphate solvate crystal and a preparation method thereof. The crystal comprises clindamycin phosphate n-butanol-water solvate crystal and clindamycin phosphate dimethyl sulfoxide-water solvate crystal. Chemical stabilities of the two crystals are good and properties thereof in the storage process are stable.

Description

[0001] This application is a divisional application of the patent application with the application number 200910019903.3, the application date is 2009.03.16, and the invention name is "clindamycin phosphate solvate crystal and its preparation method". 1. Technical field [0002] The invention belongs to the technical field of medicine, and in particular relates to a clindamycin phosphate solvate crystal and a preparation method thereof. 2. Background technology [0003] Clindamycin phosphate is a derivative of clindamycin, which is inactive in vitro. When injected into the body, it is rapidly hydrolyzed into clindamycin to exert pharmacological effects and inhibit bacterial protein synthesis. Clindamycin phosphate has the same antibacterial spectrum and antibacterial activity as clindamycin, and has antibacterial activity against Gram-positive bacteria such as Staphylococcus aureus, Streptococcus pneumoniae and hemolytic streptococcus and most anaerobic bacteria. Clindamycin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H15/16
Inventor 张在富华荣庆吴建国吴浩山
Owner ZHUHAI EBANG PHARMA
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