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Traditional Chinese medicine composition for treating endometriosis and preparation method thereof

An endometrium and composition technology, which is applied in the field of traditional Chinese medicine composition for treating endometriosis and its preparation field, can solve the problem of no pharmacological activity, drug efficacy and adverse effects on quality, dosage of Sanjie Zhentong capsules big problem

Inactive Publication Date: 2012-09-26
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, in clinical practice in recent years, the inventor also found that Sanjie Analgesic Capsules only uses the traditional process of filling capsules with full prescription powder, resulting in a large dosage of Sanjie Analgesic Capsules; at the same time, modern pharmacological studies have shown that, Many macromolecular substances such as cellulose and other components generally do not have pharmacological activity, which has a certain adverse effect on the curative effect and quality of the drug

Method used

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  • Traditional Chinese medicine composition for treating endometriosis and preparation method thereof
  • Traditional Chinese medicine composition for treating endometriosis and preparation method thereof
  • Traditional Chinese medicine composition for treating endometriosis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0311] Embodiment 1: tablet

[0312] Raw materials: Dracaena 124g, Panax notoginseng 124g, Fritillaria 200g, Coix seed 352g;

[0313] Preparation method: the above four flavors, Panax notoginseng and dragon's blood are directly crushed into fine powder and used as medicine; the medicinal materials of Fritillaria fritillaria are crushed into coarse powder, soaked in 75% ethanol for 24 hours, then percolated with 75% ethanol, and 12 times the amount of percolation fluid is collected , to obtain the extract of Fritillaria japonicus; Coix seed is crushed into coarse powder, extracted twice with 20 times the amount of 90% ethanol under reflux, each time for 2 hours, the extracts are combined, and filtered to obtain the extract of Coix seed; the above-mentioned extract of Fritillaria coix Extraction of Coix Seed and Coix Seed Extract to recover ethanol under reduced pressure, and concentrate to a thick paste. The obtained thick paste is mixed with Sanqi fine powder and dragon's bloo...

Embodiment 2

[0316] Embodiment 2: concentrated pill

[0317] Raw materials: Dracaena 80g, Panax notoginseng 80g, Fritillaria 240g, Coix seed 420g;

[0318] Preparation method: the above four flavors, Panax notoginseng and dragon's blood are directly crushed into fine powder and used as medicine; the medicinal materials of Fritillaria fritillaria are crushed into coarse powder, soaked in 65% ethanol for 12 hours, then percolated with 65% ethanol, and 16 times the amount of percolation fluid is collected , to obtain the extract of Fritillaria japonicus; Coix seed is crushed into coarse powder, refluxed and extracted with 10 times the amount of 85% ethanol for 4 hours, and the extract is filtered to obtain the extract of Coix seed; Recover ethanol under reduced pressure and concentrate to a thick paste. The obtained thick paste is mixed with Sanqi fine powder and dragon's blood fine powder, and one or more of starch, dextrin or lactose is added, dried under reduced pressure, and pulverized. ...

Embodiment 3

[0321] Embodiment 3: capsules

[0322] Raw materials: Dracaena 124g, Panax notoginseng 124g, Fritillaria 200g, Coix seed 352g;

[0323] Preparation method: the above four flavors, Panax notoginseng and dragon's blood are directly crushed into fine powder and used as medicine; the medicinal materials of Fritillaria fritillaria are crushed into coarse powder, soaked in 85% ethanol for 36 hours, then percolated with 85% ethanol, and 16 times the amount of percolation fluid is collected , to obtain the extract of Fritillaria japonicus; Coix seed is crushed into coarse powder, and refluxed with 30 times the amount of 95% ethanol to extract 3 times, each time for 3 hours, the extracts are combined and filtered to obtain the extract of Coix seed; the above-mentioned extract of Fritillaria coix Extraction of Coix Seed and Coix Seed extracts to recover ethanol under reduced pressure, and concentrate to a thick paste. The obtained thick paste is mixed with Sanqi fine powder and dragon's...

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Abstract

The invention belongs to the traditional Chinese medicine field, and relates to a traditional Chinese medicine composition for treating endometriosis and a preparation method thereof; the traditional Chinese medicine composition is prepared by the following raw material drugs by weight: 40-85 parts of dragon blood, 40-85 parts of pseudo-ginseng, 80-120 parts of Zhejiang fritillaria bulb, and 140-210 parts of coix seeds; the preparation method comprises the following steps: directly pulverizing pseudo-ginseng and dragon blood into fine powder so as to be used as medicine; crushing Zhejiang fritillaria bulb medicinal materials into crude powder, adding 65-85% ethanol, soaking for 12-36 hours, percolating with 65-85% ethanol, collecting percolated liquid with an amount of 8-16 times to obtain a Zhejiang fritillaria bulb extract; crushing coix seeds medicinal materials into crude powder, performing reflux for 1-3 times with 85-95% ethanol with an amount of 10-30 times more than that the crude powder, 1-4 hours each time, combining the extracts, filtering to obtain a coix seed extract; recovering ethanol at a reduced pressure from the Zhejiang fritillaria bulb extract and the coix seed extract, concentrating into thick paste, mixing the thick paste with pseudo-ginseng fine powder and dragon blood fine powder, drying, crushing to obtain dry extract powder, preparing and shaping.

Description

Technical field: [0001] The invention belongs to the field of traditional Chinese medicines, and relates to a traditional Chinese medicine composition for treating endometriosis and a preparation method thereof. Background technique: [0002] The applicant of the patent of the present invention applied for a Chinese invention patent on June 16, 2003, the application number is 03148877.7, and the publication number is CN 1565612A, in which a Chinese medicine combination for treating endometriosis is provided The traditional Chinese medicine composition and its preparation method have been approved by the national drug regulatory department and have been successfully marketed. The generic name of the drug is Sanjie Analgesic Capsules. [0003] Sanjie Analgesic Capsules (National Standard YBZ07712005) is a state-level new drug exclusively produced by Jiangsu Kangyuan Pharmaceutical Co., Ltd., and the drug approval number is Z20030127. The drug is widely used clinically for sec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8994A61P15/00
Inventor 萧伟王振中刘涛吴云曹亮陈俊孙兰章晨峰王团结陈凤龙
Owner JIANGSU KANION PHARMA CO LTD
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