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A kind of anthraquinone dimer derivative and its preparation method and application

An anthraquinone dimer and derivative technology is applied in the field of anthraquinone dimer derivatives and their preparation and application, which can solve the problems such as no known drugs, achieve inhibition of porcine reproductive and respiratory syndrome virus, and application prospects. expansive effect

Active Publication Date: 2016-03-02
OCEAN UNIV OF CHINA
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Problems solved by technology

The present invention has studied and learned that the anthraquinone dimer derivatives derived from the endophytic fungus Alternaria sp. (ZJ-2008003) of the South China Sea soft coral Sarcophytonsp. obtained after extraction and separation have strong Anti-Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) activity, there is no report on the activity of this compound against Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), so there is no related drug on the market

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  • A kind of anthraquinone dimer derivative and its preparation method and application
  • A kind of anthraquinone dimer derivative and its preparation method and application
  • A kind of anthraquinone dimer derivative and its preparation method and application

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Embodiment Construction

[0010] In preparing the compounds of the present invention, the following steps are taken:

[0011] (1) Carry out strain cultivation to Chinese South China Sea soft coral Sarcophytonsp. Endophytic fungus Alternariasp. (ZJ-2008003) in the strain culture medium earlier, used strain culture medium contains glucose 2.0% (percentage by weight, the same below), Potato 20.0%, agar 1.5%, coarse sea salt 3.0%, and the rest is water, which is made into a test tube slant when used, and the above fungal strains are cultivated at 28° C. for 5 days.

[0012] The strain culture medium contains 0.1%-5.0% of glucose (percentage by weight, the same below), 5.0%-40.0% of potato, 0.1%-3.0% of agar, 0.05%-5.0% of coarse sea salt, and the rest is water. The temperature is 15-35°C, and the cultivation time is 3-10 days.

[0013] (2) The fungal strains obtained from the above culture are fermented, and the fermentation medium used contains 2.0% glucose, 20.0% potato, 3.0% coarse sea salt, and the re...

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Abstract

The invention relates to anthraquinone dimer derivatives and a preparation method and application thereof. The preparation method comprises the steps of firstly conducting strain culture of an endophytic fungus Alternaria sp. (ZJ-2008003) coming from South China Sea soft coral Sarcophyton Sp. in a strain culture medium, conducting fermentation culture in a fermentation culture medium, filtering the obtained fermentation liquid, removing filtrate to obtain thalli, extracting the thalli by using methanol, concentrating the extract, conducting silica gel column chromatography, Sephadex LH-20 gel column chromatography and high-performance liquid chromatographic preparation, concentrating the eluent to obtain red powder, which is the anthraquinone dimer derivatives alterporriol Q and alterporriol R. The anthraquinone dimmer derivatives coming from marine fungi have a strong antiviral effect, can effectively inhibit porcine reproductive and respiratory syndrome viruses (PRRSV) and can be used as antiviral drugs, raw materials can be produced in a large scale and the application prospect is wide.

Description

technical field [0001] The invention relates to an anthraquinone dimer derivative extracted and separated from marine endophytic fungi, a preparation method thereof and an application as an antiviral drug. Background technique [0002] Porcine highly pathogenic PRRS is a porcine reproductive and respiratory syndrome disease caused by porcine reproductive and respiratory syndrome virus (PRRSV), which is an immunosuppressive disease. The existence of the disease was discovered in China in the 1990s, and it spread in a large area in 2000. Since the beginning of 2006, there have been outbreaks in most provinces and regions, namely "Porcine Unknown High Fever Syndrome". The epidemic feature of this disease is that the pig industry in modern China has never been seen before. The speed of transmission, the wide range of involvement, and the high morbidity and mortality are unprecedented. Since there is no specific antiviral drug at present, interferon or interferon-inducing agents...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C50/18C12N1/14A61K31/122A61P31/14C12R1/645
Inventor 王长云邵长伦郑彩娟
Owner OCEAN UNIV OF CHINA
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