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Shape fixing and keeping method for polypropylene co-mixing infusion bag

An infusion bag, polypropylene technology, applied in the field of medical devices, can solve problems such as sterilization pressure control mode and parameter mismatch, and achieve the effect of avoiding shape interference, preventing bag shrinkage, and neat shape

Active Publication Date: 2014-07-16
GUIZHOU KELUN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

4. The sterilization pressure control method and parameters do not match

Method used

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  • Shape fixing and keeping method for polypropylene co-mixing infusion bag
  • Shape fixing and keeping method for polypropylene co-mixing infusion bag
  • Shape fixing and keeping method for polypropylene co-mixing infusion bag

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029]500ml sodium chloride injection

[0030] (1) The temperature of the filling liquid is 48°C;

[0031] (2) adopt the vertical loading mode of the present invention;

[0032] (3) The sterilization temperature is 121°C, the sterilization time is 12 minutes, and the sterilization pressure is 0.19MPa; the sterilization starts at 13:21, and when the sterilization temperature reaches 121°C, the pressure reaches 0.19Mpa and heat preservation and pressure extinguishing Sterilize for 12 minutes, and the pressure in the heat preservation stage is maintained at 0.19MPa. After the completion, the pressure in the sterilizer will decrease with the temperature drop. cabinet;

[0033] (4) After sterilization, the product is full, the bag shape is uniform, and the transparency is high. The pressure inside the bag has been tested to be between 0.008-0.013MPa, which improves the ability of the bag to resist external pressure and ensures that the shape of the bag does not deform.

Embodiment 2

[0035] 100ml: glucose injection

[0036] (1) The temperature of the filling liquid is 63°C;

[0037] (2) adopt the vertical loading mode of the present invention;

[0038] (3) Sterilize with a sterilization temperature of 121°C, a sterilization time of 12 minutes, and a pressure of 0.21MPa; the sterilization starts at 10:09, and when the sterilization temperature reaches 121°C, the pressure reaches 0.21MPa and starts to maintain pressure Sterilize for 12 minutes, and the pressure in the heat preservation stage is maintained at 0.21MPa; after completion, the pressure in the sterilizer decreases with the temperature drop, and when the temperature drops to 50°C, it drops to 0.13MPa and starts to release the pressure. At 11:37, the pressure drops to normal pressure and exits. cabinet;

[0039] (3) After sterilization, the product is full, with uniform bag shape and high transparency. The pressure inside the bag is tested to be between 0.008-0.013MPa, which improves the bag's ab...

Embodiment 3

[0041] 100ml: glucose injection

[0042] (1) The temperature of the filling liquid is 50°C;

[0043] (2) adopt the vertical loading mode of the present invention;

[0044] (3) Sterilize with a sterilization temperature of 121°C, a sterilization time of 12 minutes, and a sterilization pressure of 0.24MPa; the sterilization starts at 15:23, and when the sterilization temperature reaches 121°C, the pressure reaches 0.24MPa and begins to maintain Sterilize by pressure for 12 minutes, and maintain the pressure at 0.24MPa during the heat preservation stage; after cooling down, the pressure in the cabinet will decrease with the temperature drop, and when the temperature drops to 50°C, the pressure will drop to 0.12MPa and start to release the pressure. At 16:49, the pressure will drop to 10KPa Come out when:

[0045] (3) After sterilization, the product is full, with uniform bag shape and high transparency. The pressure inside the bag is tested to be between 0.011-0.015MPa, which ...

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Abstract

The invention relates to a medical instrument and particularly relates to a shape fixing and keeping method for a polypropylene co-mixing infusion bag. The shape fixing and keeping method comprises filling of liquid medicine and sterilization of the infusion bag and is characterized in that the sterilization is carried out in a high-temperature and high-pressure environment; the temperature of the filling of the liquid medicine is controlled to be 45-65 degrees; when the infusion bag is sterilized, temperature and pressure increasing is carried out firstly, temperature and pressure keeping is carried out secondly, and temperature and pressure reducing is carried out until the temperature is reduced to below 50 DEG C, and then pressure is released and the infusion bag is taken out of the cabinet; and during sterilization, the infusion bag is positioned between two parallel vertical separating plates and in a vertical state and two wide vertical surfaces of the infusion bag cling to the surfaces of the separating plates respectively. By control on the technical conditions of filling and sterilization as well as improvement on the sterilization cabinet, the deformation problem of the polypropylene co-mixing infusion bag is solved, and the packaging, the transportation and the use of the infusion bag are facilitated. Especially, the problem that the infusion bag produced in a high altitude area deforms in a low altitude area is solved; and inconvenience in packaging and influence on self-drainage caused by the softening and deformation of the bag body in use are prevented, therefore the infusion bag is convenient to use.

Description

technical field [0001] The invention mainly relates to a medical device, in particular to a method for filling and sterilizing a polypropylene blended transfusion bag. Background technique [0002] In the prior art, the polypropylene blended infusion bag pellets are made of polypropylene (ie, PP) as the main raw material by adding the pharmaceutical grade auxiliary agent SEBS and then extruding and mixing together. Since the main raw material PP is a semi-crystalline polymer material, it is harder and has a higher melting point than PE. In view of the high degree of crystallinity, the surface rigidity and scratch resistance of this material are very good. Due to the characteristics of material crystallization, the shrinkage rate of PP is relatively high, generally 1.8-2.5%. There is a certain molecular gap, and the size of this gap has a lot to do with the structure and temperature of the material itself. But as long as there is a gap, the temperature rises, the thermal mo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61J1/10A61M5/14
Inventor 杨军曾勇廖森林向金张建强
Owner GUIZHOU KELUN PHARMA
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