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Method for extracting pleuromutilin from tiamulin fermentation liquor

A technology for pleuromutilin and tiamulin, which is applied in chemical instruments and methods, preparation of organic compounds, separation/purification of carboxylic acid esters, etc., can solve the problem of increasing environmental pollution, sewage treatment costs, and low extraction yields , increase the cost of sewage treatment and other issues, to achieve the effect of reducing pollution and sewage treatment costs, high extraction yield and low cost

Inactive Publication Date: 2012-08-15
宁夏泰瑞制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] 2. Low extraction yield
[0009] 3. Increased environmental pollution and sewage treatment costs
Methyl ethyl butyl ketone is used to extract pleuromutilin, and the bacteria residue is treated after completion. The discharged wastewater contains a large amount of methyl ethyl butyl ketone, which increases the cost of sewage treatment.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1 Using methanol to extract pleuromutilin

[0028] Tiamulin fermentation broth was filtered with a box-type plate and frame filter press. Discharge the filtrate into the waste liquid pool, and gradually increase the feeding pressure of the plate and frame to 0.45MPa. After the plate and frame are full, stop feeding, and clean the inner material of the plate and frame with drinking water until the liquid becomes clear. Use compressed air to blow the plate and frame until no filtrate flows out, then remove and wash the plate and frame. The wet fungus residue is placed in the designated place.

[0029] Preheat the flash dryer for half an hour, turn on the blower, control the inlet air temperature at 100-105°C, and the outlet air temperature at 70-75°C. Continuously put the filtered wet fungal residue into the feeding port of the flash dryer, collect the dried fungal residue at the outlet, control the feeding speed at 50-100r / min, and perform flash drying. After ...

Embodiment 2

[0031] Example 2 Using Methanol to Extract Pleuromutilin

[0032] Tiamulin fermentation broth was filtered with a box-type plate and frame filter press. Discharge the filtrate into the waste liquid pool, and gradually increase the feeding pressure of the plate and frame to 0.45MPa. After the plate and frame are full, stop feeding, and clean the inner material of the plate and frame with drinking water until the liquid becomes clear. Use compressed air to blow the plate and frame until no filtrate flows out, then remove and wash the plate and frame. The wet fungus residue is placed in the designated place.

[0033] Preheat the flash dryer for half an hour, turn on the blower, control the inlet air temperature at 110-115°C, and control the outlet air temperature at 80-85°C. Continuously put the filtered wet fungal residue into the feeding port of the flash dryer, collect the dried fungal residue at the discharge port, control the feeding speed at 200-300r / min, and carry out fl...

Embodiment 3

[0035] Example 3 Using Methanol to Extract Pleuromutilin

[0036] Tiamulin fermentation broth was filtered with a box-type plate and frame filter press. Discharge the filtrate into the waste liquid pool, and gradually increase the feeding pressure of the plate and frame to 0.45MPa. After the plate and frame are full, stop feeding, and clean the inner material of the plate and frame with drinking water until the liquid becomes clear. Use compressed air to blow the plate and frame until no filtrate flows out, then remove and wash the plate and frame. The wet fungus residue is placed in the designated place.

[0037] Preheat the flash dryer for half an hour, turn on the blower, control the inlet air temperature at 115-120°C, and control the outlet air temperature at 85-90°C. Continuously put the filtered wet fungal residue into the feeding port of the flash dryer, collect the dried fungal residue at the outlet, control the feeding speed at 300-400r / min, and carry out flash dryi...

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PUM

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Abstract

A method for extracting pleuromutilin from tiamulin fermentation liquor is characterized by including: firstly, filtering the tiamulin fermentation liquor, leading obtained wet fungus dregs to undergo flash vaporization, then extracting by utilizing methyl alcohol as solvent, and concentrating extraction liquid to obtain pleuromutilin concentrated liquor. The pleuromutilin is extracted from the tiamulin fermentation liquor by utilizing the methyl alcohol as the solvent, and the method has the advantages of small use amount of organic solvent, high extraction yield, low production cost and the like.

Description

technical field [0001] The invention belongs to the technical field of biomedicine extraction, in particular to a method for extracting pleuromutilin from tiamulin fermentation broth. Background technique [0002] Pleuromutilin is a diterpene antibiotic, and tiamulin can be obtained by semi-synthesis from pleuromutilin. As antibiotic drugs, pleuromutilin and tiamulin fumarate are widely used as veterinary drugs and are used in the form of feed additives, mainly for poultry and livestock. Adding this product to feed can effectively prevent many infectious diseases The main function is to resist Gram bacteria, Treponema (Helicobacter), Leptospirosis and Mycoplasma, etc., especially against Staphylococcus aureus, Streptococcus, various mycoplasma and some spirochetes. [0003] At present, the source of the raw material of pleuromutilin used in the synthesis of tiamulin fumarate is mainly to use organic solvents to extract the pleuromutilin fermentation liquor residue, and diss...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C69/675C07C67/56C07C67/48
Inventor 任勇冷晓红王友善奇乃周丽娜
Owner 宁夏泰瑞制药股份有限公司
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