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Anthraquinone dimer derivative alterporriol P and its preparation method and application

An anthraquinone dimer and derivative technology, which is applied to the anthraquinone dimer derivative Alterporriol P and its preparation and application fields, can solve problems such as no anti-tumor drugs, and achieve obvious proliferation inhibitory activity and application prospects. expansive effect

Active Publication Date: 2016-02-03
OCEAN UNIV OF CHINA
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  • Abstract
  • Description
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Problems solved by technology

However, there is no report on obtaining medicinally valuable anthraquinone dimer derivatives and anti-cell proliferation inhibitory activities from marine fungi, so there is no anti-tumor drug related to this in the market.

Method used

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  • Anthraquinone dimer derivative alterporriol P and its preparation method and application
  • Anthraquinone dimer derivative alterporriol P and its preparation method and application
  • Anthraquinone dimer derivative alterporriol P and its preparation method and application

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Embodiment Construction

[0009] In preparing the compounds of the present invention, the following steps are taken:

[0010] (1) Carry out strain culture to the endophytic fungus Alternariasp. (ZJ-2008003) that is derived from the soft coral Sarcophytonsp. in the South China Sea earlier in the strain culture medium, and the strain culture medium used contains glucose 2.0% (percentage by weight, The same below), potato 20.0%, agar 1.5%, coarse sea salt 3.0%, and the rest is water, which is made into a test tube slant during use, and the above-mentioned fungal strains are cultivated at 28° C. for 5 days.

[0011] The strain culture medium contains 0.1%-5.0% of glucose (percentage by weight, the same below), 5.0%-40.0% of potato, 0.1%-3.0% of agar, 0.05%-5.0% of coarse sea salt, and the rest is water. The temperature is 15-35°C, and the cultivation time is 3-10 days.

[0012] (2) The fungal strains obtained from the above culture are fermented, and the fermentation medium used contains 2.0% glucose, 20....

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Abstract

The invention relates to an anthraquinone dimer derivative and a preparation method and application thereof. The preparation method comprises the following steps of: performing strain culture on endophytic fungi Alternaria sp. (ZJ-2008003) from alcyonacea Sarcophyton sp. in South China Sea in a strain culture medium, performing fermentation cultivation in a fermentation medium, filtering the obtained fermentation solution to obtain thalli, and extracting the obtained thalli by using methanol; and concentrating the extract, performing silica-gel column chromatography, Sephadex LH-20 gel column chromatography and high performance liquid chromatography preparation, concentrating the obtained eluate, and thus obtaining red powder, namely the anthraquinone dimer derivative Alterporriol P. The anthraquinone dimer derivative from the marine fungi has a strong effect of resisting cell proliferation of human prostatic cancer PC-3 and human colon cancer HCT-116, and can be used as a cell proliferation inhibitor or an anti-tumor agent; and the raw material can be produced in large scale, so the derivative has a broad application prospect.

Description

technical field [0001] The invention relates to an anthraquinone dimer derivative alterporriolP extracted and separated from marine endophytic fungus cells, a preparation method thereof and an application as an antitumor drug. Background technique [0002] Recently, with the in-depth research on marine microbial metabolites, some quinone compounds with novel structures and significant activities have been isolated from marine microbial metabolites. biological activity. However, there is no report on obtaining medicinally valuable anthraquinone dimer derivatives and anti-cell proliferation inhibitory activity from marine fungi, so there is no anti-tumor drug related to this in the market. Contents of the invention [0003] The object of the present invention is to provide a kind of anthraquinone dimer derivatives extracted and isolated from the thalline of the soft coral Sarcophytonsp. endophytic fungus Alternariasp. (ZJ-2008003) in the South China Sea and its preparation ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C50/34C12P7/66A61P35/00C12R1/645
Inventor 王长云邵长伦郑彩娟
Owner OCEAN UNIV OF CHINA
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