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Capillary parabolic shape capillary liquid chromatography preparative column

A parabolic, capillary liquid technology, applied in measuring devices, instruments, scientific instruments, etc., can solve the problem of no parabolic high performance liquid chromatography preparation column, and achieve the effects of reducing solvent consumption, production cost, and processing cost.

Inactive Publication Date: 2014-08-20
SOOCHOW HIGH TECH CHROMATOGRAPHY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But so far, there is no report about the parabolic HPLC preparative column

Method used

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  • Capillary parabolic shape capillary liquid chromatography preparative column
  • Capillary parabolic shape capillary liquid chromatography preparative column

Examples

Experimental program
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Effect test

Embodiment 1

[0029]A capillary parabolic high performance capillary liquid chromatography preparative column, comprising: a column head located at the upper part of the column body, a parabolic tubular column body and a column tail located at the lower part of the column body; The inlet and outlet of the cylinder;

[0030] The parabolic tubular cylinder has an open flat oval inlet end with an inner diameter gradually decreasing and a uniform transition, and an open flat rhombus outlet end with an inner diameter gradually increasing and a uniform transition. Inlet tube molded integrally with the tubular cylinder, the outlet end has an outlet tube molded integrally with the parabolic tubular cylinder to maintain a uniform flow of the liquid phase mobile phase out of the parabola with first decreasing and then increasing shaped tubular cylinder;

[0031] The inner diameter of the parabolic tubular cylinder is 2R=100um~150um, the inner diameter of the outlet 2r=30um~60um, the column length L=...

Embodiment 2

[0038] A capillary parabolic high performance capillary liquid chromatography preparative column, comprising: a column head located at the upper part of the column body, a parabolic tubular column body and a column tail located at the lower part of the column body; The inlet and outlet of the cylinder;

[0039] The parabolic tubular cylinder has an open flat oval inlet end with an inner diameter gradually decreasing and a uniform transition, and an open flat rhombus outlet end with an inner diameter gradually increasing and a uniform transition. Inlet tube molded integrally with the tubular cylinder, the outlet end has an outlet tube molded integrally with the parabolic tubular cylinder to maintain a uniform flow of the liquid phase mobile phase out of the parabola with first decreasing and then increasing shaped tubular cylinder;

[0040] The inner diameter of the parabolic tubular cylinder is 2R=100um~150um, the inner diameter of the outlet 2r=30um~60um, the column length L...

Embodiment 3

[0047] A capillary parabolic high performance capillary liquid chromatography preparative column, comprising: a column head located at the upper part of the column body, a parabolic tubular column body and a column tail located at the lower part of the column body; The inlet and outlet of the cylinder;

[0048] The parabolic tubular cylinder has an open flat oval inlet end with an inner diameter gradually decreasing and a uniform transition, and an open flat rhombus outlet end with an inner diameter gradually increasing and a uniform transition. Inlet tube molded integrally with the tubular cylinder, the outlet end has an outlet tube molded integrally with the parabolic tubular cylinder to maintain a uniform flow of the liquid phase mobile phase out of the parabola with first decreasing and then increasing shaped tubular cylinder;

[0049] The inner diameter of the parabolic tubular cylinder is 2R=100um~150um, the inner diameter of the outlet 2r=30um~60um, the column length L...

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Abstract

The invention relates to a capillary parabolic shape capillary liquid chromatography preparative column, the capillary liquid chromatography preparative column comprises: a column head positioned at the upper part of the column body, a parabolic shape tubular column body and a column end positioned at the lower part of the column body; wherein the column body enables a parabolic shape design, and the parabolic equation is corresponding to the flow velocity, and a perfect plug-like chromatographic band, column efficiency of the chromatographic column can be substantially enhanced, the internal diameter of the column body can be gradually decreased, sample-carrying amount of the chromatographic column is increased, a certain amount of enrichment effect on the sample is provided, and the preparation cost can be greatly reduced.

Description

technical field [0001] The invention relates to a high performance liquid chromatography column, in particular to a capillary parabolic high performance capillary liquid chromatography preparation column. Background technique [0002] Chromatography originated in 1906, when Russian botanist M.S. Tswett separated plant pigments by chromatography for the first time. Early preparative liquid chromatography was mainly used for the separation and purification of organic compounds and petroleum products, and the requirements for product purity were not high. Therefore, the past view was that column efficiency was not the main problem in preparative column chromatography, and what people really cared about was the unit. time production. However, since the 1980s, the development of pharmaceuticals and biotechnology has required samples such as drugs, proteins, and nucleic acids to have a purity of more than 95%, or even 99.9%, and the preparation volume must not only meet the requi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/60
Inventor 邵平刘翻戈兆松张维冰
Owner SOOCHOW HIGH TECH CHROMATOGRAPHY
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