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Preparation method of chitosan-based antibacterial membrane material

A chitosan and antibacterial film technology, applied in the field of green chemistry, can solve the problems of the limited bacteriostatic effect of chitosan and the need to improve the mechanical properties of the film, so as to achieve the improvement of antimicrobial activity and strength and toughness, reduce biological irritation, enhance Antibacterial effect

Inactive Publication Date: 2012-08-01
WUHAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the antibacterial effect of chitosan is limited, and the mechanical properties of the membrane prepared by pure chitosan also need to be improved.

Method used

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  • Preparation method of chitosan-based antibacterial membrane material
  • Preparation method of chitosan-based antibacterial membrane material
  • Preparation method of chitosan-based antibacterial membrane material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 2g chitosan (molecular weight 25×10 4 Da, degree of deacetylation 85%) was dissolved in 80 ml of 1% (v / v) acetic acid solution, magnetically stirred until the solution was clear and transparent, and then left to defoam. Dissolve 2 g of povidone-iodine in 20 ml of water, and stir magnetically until the solution is clear. After the bubbles of the above two solutions are removed, the chitosan solution is slowly injected into the povidone-iodine solution, and stirred while adding. At room temperature, keep stirring for 2.5-3.5 hours until the complexation is balanced, and a uniform viscous solution of maroon color is obtained. Stop stirring, centrifuge at a speed of 6000r / min for 15min, then slowly pour out the supernatant in the centrifuge tube to spread the film. Dry at 40°C to obtain the chitosan-based antibacterial film.

Embodiment 2

[0028] 2g chitosan (molecular weight 2×10 4 Da, degree of deacetylation 85%) was dissolved in 80 ml of 1% (v / v) acetic acid solution, magnetically stirred until the solution was clear and transparent, and then left to defoam. Dissolve 1 g of povidone-iodine in 20 ml of water, and magnetically stir until the solution is clear. After the bubbles of the above two solutions are removed, the chitosan solution is slowly injected into the povidone-iodine solution, and stirred while adding. At room temperature, keep stirring for 2.5-3.5 hours until the complexation is balanced, and a uniform viscous solution of maroon color is obtained. Stop stirring, centrifuge at a speed of 6000r / min for 15min, then slowly pour out the supernatant in the centrifuge tube to spread the film. Dry at 40°C to obtain the chitosan-based antibacterial film.

Embodiment 3

[0030] 0.5g chitosan (molecular weight 25×10 4 Da, degree of deacetylation 75%) was dissolved in 80 ml of 1% (v / v) acetic acid solution, stirred by magnetic force until the solution was clear and transparent, then left to defoam. Take 0.01g of povidone-iodine and dissolve it in 20ml of water, and magnetically stir until the solution is clear. After the bubbles of the above two solutions are removed, the chitosan solution is slowly injected into the povidone-iodine solution, and stirred while adding. At room temperature, keep stirring for 2.5-3.5 hours until the complexation is balanced, and a uniform viscous solution of maroon color is obtained. Stop stirring, centrifuge at a speed of 6000r / min for 15min, then slowly pour out the supernatant in the centrifuge tube to spread the film. Dry at 40°C to obtain the chitosan-based antibacterial film.

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Abstract

The invention discloses a method for preparing a chitosan-based antibacterial membrane material. The method comprises the following steps of: dissolving chitosan into a diluted acid solution with a certain concentration; adding a polyvinylpyrrolidone iodine solution to agitate at a room temperature to react for more than 2.5 hours; after centrifuging and separating an agitated solution, taking liquid supernatant to pave a membrane; and drying at 40 DEG C to obtain a chitosan-based antibacterial membrane. The prepared chitosan-based antibacterial membrane material has the antibacterial activity which is more durable and effective, improves the stability of effective iodine and has good iodine slow-releasing performance and mechanical property. The novel antibacterial membrane material disclosed by the invention can be used for medical surgical dressings, the antibacterial membrane material and the like to have a wide application prospect in the fields including foods, medicines, textile industry and the like.

Description

[0001] technical field [0002] The invention relates to a preparation method of a chitosan-based antibacterial film material, belonging to the field of green chemistry. Background technique [0003] Chitin is a natural polymer material extracted from the shells of crustaceans such as shrimp and crabs and the cell walls of lower plants such as algae. It is the second largest biologically derived resource in nature after cellulose. Chitosan is the deacetylation product of chitin, the only alkaline polysaccharide in nature, has good biocompatibility and antibacterial properties, and is easy to degrade in the natural environment, non-toxic, harmless and pollution-free. It has broad application prospects in the fields of medical supplies, printing and dyeing, wastewater treatment and cosmetics. [0004] Most of the existing commercial antibacterial agents are toxic to the human body and not easy to degrade under natural conditions, so it is imperative to develop an antibacteria...

Claims

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Application Information

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IPC IPC(8): C08J5/18C08L5/08C08L39/06A61L15/28
Inventor 施晓文李泽鹏李明宜胡立鹃熊媛李苏奇高广军
Owner WUHAN UNIV
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