Naphthlamide derivative used as protein kinase inhibitor and histone deacetylase inhibitor and preparation method of naphthlamide derivative

Abstract

The invention relates to a naphthlamide derivative used as a protein kinase inhibitor and a histone deacetylase inhibitor. The structure of the naphthlamide derivative is as shown as a formula I, wherein a position 7 is provided with substituent groups R which include F, Cl, Br, I, OCH3 and other substituent groups as shown in the accompanying drawings, and the names of the substituent groups arefluorine, chlorine, bromine, iodine, methoxyl, 4-morpholinyl ethyoxyl, 4-morpholinyl methyl phenyl, acryloyl amino and 2-beuteamide. The naphthlamide derivative used as the protein kinase inhibitor and the histone deacetylase inhibitor can be used for curing cardiovascular diseases, metabolic diseases, allergy, cancers and hormone-related diseases. The invention additionally provides a synthesis method of the compound. The method has the advantages that the raw materials are easy to obtain, the method is simple to operate and the method is suitable for large-scale industrial production.

Description

Technical field: [0001] The present invention relates to the preparation method of medicine. Specifically, it relates to a preparation method of naphthylamide derivatives of protein kinase inhibitors and histone deacetylase inhibitors. Background technique: [0002] Naphthalene amide derivatives of protein kinase inhibitors and histone deacetylase inhibitors have therapeutic properties including cardiovascular diseases, metabolic diseases, allergies, cancer, and hormone-related diseases. The chemical name of the patented compound is: N-(2-anilino)-6-(7-substituted quinoline-4-etheroxy)-2-naphthylamide (7-position has substituent R=F, Cl, Br , I, OCH 3 , )(Note: The Chinese names of these substituents R are: fluorine, chlorine, bromine, iodine, methoxy, 4-morpholinoethoxy, 4-morpholinomethylphenyl, acrylamide, 2 -butylenamide), the structural formula is as follows: [0003] [0004] A large number of clinical trials have shown that this type of compound has both prot...

AI Technical Summary

Problems solved by technology

In this type of method, i) the cesium carbonate that the ether-forming reaction catalyst of the first step 6-hydroxynaphthoic acid and 4-chloroquinoline uses is expensive, and the toxicity is relatively large, and the pollution to the environment is large; ii) the reaction conditions are harsh, and the product low rate

Therefore, this preparation method is not easy to industrialize

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