Tumor diagnosis reagent or kit based on detection of IGFBP-2 (insulin-like growth factor binding protein 2) autoantibody or combined detection of IGFBP-2 antoantibody and IGFBP-2, as well as application thereof

A technology of IGFBP-2 and autoantibodies, applied in measurement devices, instruments, scientific instruments, etc., can solve problems such as unsatisfactory diagnosis of early cancer

Active Publication Date: 2014-07-23
BEIJING CANCER HOSPITAL PEKING UNIV CANCER HOSPITAL +1
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Problems solved by technology

Therefore, IGFBP-2 is not ideal for the diagnosis of early cancer, such as: glioma (22-25)

Method used

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  • Tumor diagnosis reagent or kit based on detection of IGFBP-2 (insulin-like growth factor binding protein 2) autoantibody or combined detection of IGFBP-2 antoantibody and IGFBP-2, as well as application thereof
  • Tumor diagnosis reagent or kit based on detection of IGFBP-2 (insulin-like growth factor binding protein 2) autoantibody or combined detection of IGFBP-2 antoantibody and IGFBP-2, as well as application thereof
  • Tumor diagnosis reagent or kit based on detection of IGFBP-2 (insulin-like growth factor binding protein 2) autoantibody or combined detection of IGFBP-2 antoantibody and IGFBP-2, as well as application thereof

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[0067] The following examples illustrate the present invention in more detail, but this does not mean that the protection scope of the present invention is limited by these examples.

[0068] An overview of embodiments of the invention follows.

[0069] Study patients and research methods: Glioma and colorectal tumor were used as research models. Serum IGFBP-2 and IGFBP-2 autoantibody concentrations were detected in 260 cancer patients (145 glioma patients, 45 colorectal polyposis patients and 70 colorectal tumor patients). ROC curves were used to assess diagnostic ability.

[0070] Results: Compared with the serum IGFBP-2-Abs concentration of the normal control group (mean: 11ng / ml, median: 0ng / ml, range: 0-212ng / ml), the serum IGFBP-2 autoantibody concentration (IGFBP- 2-Abs) was significantly increased in tumors (mean: 82ng / ml, median: 17ng / ml, range: 0-1387ng / ml) (P<0.0001), and its concentration was higher in the serum of early cancer patients, Contrary to the concentr...

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Abstract

The invention provides a tumor diagnosis reagent or kit based on detection of an IGFBP-2 (insulin-like growth factor binding protein 2) autoantibody or combined detection of the IGFBP-2 autoantibody IGFBP-2. The tumor diagnosis reagent or kit comprises a first reagent group capable of detecting the IGFBP-2 autoantibody in a detected sample, or a first reagent group capable of detecting the IGFBP-2 autoantibody in the detected sample and a second reagent group capable of detecting IGFBP-2 in the detected sample. The invention also provides application of IGFBP-2 autoantibody detection or combined detection of the IGFBP-2 autoantibody and the IGFBP-2 in preparing the tumor diagnosis reagent or kit. Detection of the IGFBP-2 autoantibody can be used for diagnosing early-phase tumor or high-grade adenoma with cancerization risk, in particular for diagnosing prometaphase glioma and high-grade colorectal polyp and / or colorectal neoplasms of I-II grades with cancerization risk; and the combined detection of the IGFBP-2 autoantibody and the IGFBP-2 can be used for diagnosing tumors of different grades and monitoring each phase of a tumor from low grade to high grade, such as diagnosing and identifying astrocytoma, anaplastic astrocytoma and / or spongioblastoma, as well as I-IV grades of colorectal neoplasms.

Description

technical field [0001] The present invention relates to a tumor diagnostic reagent or kit based on the detection of IGFBP-2 autoantibodies (IGFBP-2-Abs) or its combination with IGFBP-2, and the detection of IGFBP-2 autoantibodies or its combination with IGFBP-2 The application of combined detection in the preparation of tumor diagnostic reagents or kits. Specifically, the detection of IGFBP-2 autoantibodies in the present invention can diagnose early-stage tumors or high-grade adenomas with cancer risk, especially early and middle-stage gliomas and high-grade colorectal polyps with cancer risk and / or Or colorectal tumor grade I-II, the combined detection of IGFBP-2 autoantibody and IGFBP-2 can diagnose tumors of different grades and monitor the various stages of tumor progression from low grade to high grade, such as diagnosis and identification of astrocytes Glioblastoma, anaplastic astrocytoma, and / or glioblastoma, and colorectal tumors grades I-IV. Background technique ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/574
Inventor 宋韦江涛李雨晨张靖
Owner BEIJING CANCER HOSPITAL PEKING UNIV CANCER HOSPITAL
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