Tumor diagnosis reagent or kit based on detection of IGFBP-2 (insulin-like growth factor binding protein 2) autoantibody or combined detection of IGFBP-2 antoantibody and IGFBP-2, as well as application thereof
A technology of IGFBP-2 and autoantibodies, applied in measurement devices, instruments, scientific instruments, etc., can solve problems such as unsatisfactory diagnosis of early cancer
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[0067] The following examples illustrate the present invention in more detail, but this does not mean that the protection scope of the present invention is limited by these examples.
[0068] An overview of embodiments of the invention follows.
[0069] Study patients and research methods: Glioma and colorectal tumor were used as research models. Serum IGFBP-2 and IGFBP-2 autoantibody concentrations were detected in 260 cancer patients (145 glioma patients, 45 colorectal polyposis patients and 70 colorectal tumor patients). ROC curves were used to assess diagnostic ability.
[0070] Results: Compared with the serum IGFBP-2-Abs concentration of the normal control group (mean: 11ng / ml, median: 0ng / ml, range: 0-212ng / ml), the serum IGFBP-2 autoantibody concentration (IGFBP- 2-Abs) was significantly increased in tumors (mean: 82ng / ml, median: 17ng / ml, range: 0-1387ng / ml) (P<0.0001), and its concentration was higher in the serum of early cancer patients, Contrary to the concentr...
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