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Application of thymosin extrasin alpha in preparing medicine for preventing and curing cancer of liver

A technology for the treatment of liver cancer and thymosin, applied in drug combinations, antineoplastic drugs, pharmaceutical formulations, etc.

Inactive Publication Date: 2012-07-18
XIAMEN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, there is no report about prothymosin α inhibiting the activity of regulatory T lymphocytes to prevent and treat liver cancer.

Method used

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  • Application of thymosin extrasin alpha in preparing medicine for preventing and curing cancer of liver
  • Application of thymosin extrasin alpha in preparing medicine for preventing and curing cancer of liver
  • Application of thymosin extrasin alpha in preparing medicine for preventing and curing cancer of liver

Examples

Experimental program
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Embodiment approach

[0053] 2.1 Tumor inhibition rate experiment

[0054] Recombinant human prethymosin α proprotein inhibits mouse liver cancer H22 and inhibits regulatory T lymphocyte activity experiments. Select tumor-bearing mice with good growth conditions 15 days after intraperitoneal inoculation of H22, and aseptically absorb ascites from the peritoneal cavity with a disposable syringe. Dilute the cells with saline, wash twice, and then dilute the cells with normal saline to 8×10 6 cells / ml, the viable cell count was greater than 95%, and 0.2ml of tumor cell suspension was inoculated subcutaneously in the right armpit of mice. After the subcutaneous tumor grew to a size of 0.3-0.4cm 7-8 days after inoculation, the tumor tissue was separated and cut into 0.5mm-sized tissue under aseptic conditions. At the same time, 30 mice were subjected to open surgery under aseptic conditions to expose part of the liver. , the tumor tissue was pushed into the liver with a needle, and then the opening was...

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Abstract

Application of thymosin extrasin alpha in preparing medicines for preventing and curing cancer of the liver relates to thymosin extrasin alpha, and effect of the thymosin extrasin alpha in restaining regulatory T-lymphocyte cells is further provided. The effect of recombinant proteins in preventing and curing the cancers of the liver is observed by injecting the thymosin extrasin alpha in intraperitoneal mode, and size of the tumor of the liver and ascites forming prevention are included. Through injection treatment and prevention of the thymosin extrasin alpha, growth of the tumor of the liver can be obviously restrained and simultaneously formation of the ascites can be reduced. By observing level of the regulatory T-lymphocyte cells of mouse splenic organs, the level of the regulatory T-lymphocyte cells of splenic organs in a contrast group is proved to be obviously higher than that of regulatory T-lymphocyte cells of normal mouse splenic organs, and difference is remarkable (P<0.01); and the level of the regulatory T-lymphocyte cells of splenic organs in a medicine-used group is obviously lower than that of the normal contrast group and the experiment contrast group, and the difference is obvious (P<0.01).

Description

technical field [0001] The invention relates to prothymosin α, in particular to the use of prothymosin α in the preparation of drugs for preventing and treating liver cancer. Background technique [0002] In 1984, Haritos et al. isolated a polypeptide containing 111 amino acid residues from the rat thymus. Since its N-terminal contained the sequences of all members of the prothymosin α family, it was named prothymosin α. Human ProTα consists of 109 amino acid residues. Compared with the sequence of rat ProTα, there are 6 differences, including 4 substitutions and 2 deletions (1, Haritos AA, Goodall GJ, Horecker BL, Prothymosin alpha: isolation and properties of the major immunoreactive form of thymosin alpha in rat thymus. Proc Natl Acad Sci U S A, 1984, 81: 1008; 2, Haritos AA. Alpha-thymosins: relationships in structure, distribution, and function . Isozymes Curr Top Biol Med Res 1987, 14: 123-152; 3. Goodall GJ, Dominguez F, Horecker BL. Molecular cloning of cDNA for hum...

Claims

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Application Information

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IPC IPC(8): A61K38/22A61P35/00
Inventor 周克夫王世媛粟华蔡报伟朱苑婷
Owner XIAMEN UNIV
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