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Application of sanguinarine to preparation of ionizing radiation protective agent

A technology of ionizing radiation and sanguinarine, applied in skin diseases, drug combinations, etc., to reduce occupational exposure, reduce toxic side effects, and prevent biological hazards

Inactive Publication Date: 2012-07-11
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no report that sanguinarine can be used as a protective agent in radiotherapy

Method used

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  • Application of sanguinarine to preparation of ionizing radiation protective agent
  • Application of sanguinarine to preparation of ionizing radiation protective agent
  • Application of sanguinarine to preparation of ionizing radiation protective agent

Examples

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Embodiment 1

[0017] (1) The animals used in the examples are male BalBc mice, females, weighing 26-30 g, 10W weeks old, provided by the Experimental Animal Center of Soochow University School of Medicine. The medicine used in the embodiment is: sanguinarine, purchased from Sigma Company, formulated with absolute ethanol to make 1.66mg / ml, stored at -20°C for later use, and diluted with 0.9% NaCl to the required concentration before use.

[0018] (2) 30 mice were randomly divided into 3 groups according to body weight, 10 mice in each group, and there was no difference between the groups (P>0.05): normal control group, 0.1ml / mouse normal saline was injected intraperitoneally 0.5 hours before irradiation, and no irradiation was performed; In the irradiation group, 0.1ml / piece of normal saline was injected intraperitoneally 0.5h before irradiation, and the whole body was irradiated with X-rays; kg, X-ray whole body irradiation. After irradiation, the body weight, diet and general biobehavior...

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Abstract

The invention belongs to the field of radiation protective agents, and in particular relates to new application of sanguinarine to the preparation of an ionizing radiation protective agent. The sanguinarine serving as the ionizing radiation protective agent can prolong the survival days of mice injured by radiation obviously, improve the survival rate of the mice obviously and reduce intestine injury, liver injury and pneumorrhagia of the mice injured by radiation obviously. Therefore, in actual application, practitioners who are engaged in radioactive work, patients who receive radiotherapy or other personnel who suffer from radioactive injury are subjected to the pretreatment of the sanguinarine before being exposed to ionizing radiation, the occupation exposure of radiation injury can be reduced, toxic and side effects caused by the radiotherapy can be relieved, and biohazards and the like caused by nuclear leakage can be prevented.

Description

technical field [0001] The invention belongs to the field of radiation protection agents, and in particular relates to the new application of sanguinarine as a radiation protection agent. Background technique [0002] Potential high-dose ionizing radiation in the environment, radiation accidents, and clinically applied high-dose radiation therapy for tumors all bring certain ionizing radiation damage to the human body, resulting in the occurrence of various symptoms and diseases. Therefore, how to effectively prevent and treat ionizing radiation The damage caused by radiation has attracted more and more attention. Especially in the field of tumor radiotherapy, it is of great significance to search for and discover drugs that can protect normal tissue cells from radiation but not tumor cells. An ideal radioprotectant should be able to increase the dose of radiotherapy on the premise of ensuring that normal organs and tissues are not affected, so as to better achieve the purp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4741A61P17/16
Inventor 徐加英樊赛军崇羽焦旸赵琳秦立强杨洋
Owner SUZHOU UNIV
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