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Extraction method and application of chroogomphus rutilus polysaccharide

An extraction method and a technology for mushroom polysaccharide, which are applied in the fields of food health care and drug development, and can solve the problems that the active ingredients and mechanisms of the effective substances against motion sickness have not been reported in the report.

Active Publication Date: 2013-11-06
承德森源绿色食品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have found that mushroom clear soup can effectively prevent the occurrence of space motion sickness, but its active ingredients and mechanism, and the effective substances in mushroom clear soup against motion sickness have not been reported

Method used

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  • Extraction method and application of chroogomphus rutilus polysaccharide
  • Extraction method and application of chroogomphus rutilus polysaccharide
  • Extraction method and application of chroogomphus rutilus polysaccharide

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Experimental program
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Embodiment

[0081] 1. Extraction of polysaccharide

[0082] (1) hot water extraction

[0083]Get 680g of the fruiting body of the fungus of the mushroom, wash it three times with distilled water, put it into an oven, dry it at 45°C, dry it to obtain 650g of the fruiting body of the fungus of the mushroom, and then pulverize it with water: fruiting body = 10ml: 1g The proportion of water added is heated in a water bath at 80°C, and stirred, the extraction time is 10h, centrifuged, the supernatant extract is taken, and the fruiting body precipitate obtained after centrifugation is recovered, and the above steps are repeated twice, and three times The resulting extracts were combined and concentrated to 1 / 3 of the total volume of the extracts obtained three times in a rotary evaporator;

[0084] (2) Ethanol precipitation

[0085] Add 3 times the volume of ethanol with a mass concentration of 95% to the concentrated extract, precipitate at 4°C for more than 10 hours, wash the precipitate wi...

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Abstract

The invention discloses an extraction method and application of chroogomphus rutilus polysaccharide with anti-motion sickness effects. The polysaccharide takes chroogomphus rutilus as a raw material, and is prepared by a water extraction and alcohol precipitation method. The chroogomphus rutilus polysaccharide is used for prevention and treatment of motion sickness, and the results show that very good anti-motion sickness effects can be provided when 200mg / kg of chroogomphus rutilus polysaccharide is given to the stomach by behavioral experiments and hormone level tests. The motion sickness symptoms such as visceral discomfort, incontinence, piloerection and tremor can be obviously reduced, and the level of 5-HT in serum can be reduced, and the motilin level is improved; and most importantly, rats are in good spirits, has no low spirits and other side effect symptoms. The 200mg / kg of chroogomphus rutilus polysaccharide is an ideal dose for the polysaccharide anti-motion sickness. The extraction method provides a novel material and a reference dose for further development of novel anti-motion sickness drugs with efficient, non-toxic and non-side effects.

Description

technical field [0001] The invention relates to a polysaccharide extracted from Chroogomphus rutilus and its application in anti-motion sickness, and belongs to the technical field of food health care and drug development. Background technique [0002] Motion sickness is a general term for motion sickness, seasickness, airsickness, and space sickness. Symptoms include a series of autonomic reactions such as dizziness, vertigo, nausea, vomiting, pale complexion, and cold sweats. The main cause is that abnormal movement and low-frequency noise make the vestibular, auditory and visual afferents different from the experience information stored in the central nervous system, resulting in symptoms of autonomic dysfunction and sensory discomfort. Although the disease is only sensory and mental discomfort for the general population, it does not have much impact on health, mental state and future work after recovery, but it has serious harm to soldiers, pilots and astronauts who figh...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/00A61K31/715A61P1/08
Inventor 管振龙王立安刘亚宁王宇辰王微王艳芹
Owner 承德森源绿色食品有限公司
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