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Isosorbide mononitrate and preparation technology thereof

A technology of isosorbide dinitrate and drugs, applied in the field of medicine, can solve the problems of large toxic and side effects, easy to repeat, slow onset, etc., achieve the effect of low price, improve heart index, and not suitable for recurrence

Active Publication Date: 2012-07-04
仁和堂药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its purpose is to solve the problem of treating angina pectoris, overcoming the slow onset of effect of western medicine isosorbide mononitrate, easy to repeat drug withdrawal, and serious side effects, so as to achieve the goal of treating both symptoms and root causes

Method used

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  • Isosorbide mononitrate and preparation technology thereof
  • Isosorbide mononitrate and preparation technology thereof
  • Isosorbide mononitrate and preparation technology thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] A compound isosorbide mononitrate pharmaceutical composition is characterized in that it is prepared from the following weight ratio raw materials,

[0041] 0.3 parts of isosorbide mononitrate, 25 parts of astragalus, 20 parts of Chuanxiong, 15 parts of antlers, 12 parts of Trichosanthes

[0042] The above composition is prepared into dosage forms such as capsules, tablets, granules, etc. after adding pharmaceutical excipients such as starch or edible cellulose according to the usual pharmaceutical method.

[0043] Preferably, the preparation method of the compound isosorbide mononitrate pharmaceutical composition is: take 0.3g of isosorbide mononitrate, 25g of Astragalus membranaceus, 20g of Chuanxiong, 15g of antlers, and 12g of Trichosanthes trinitrate, and grind them into capsules according to a conventional method. 0.5g, it is a finished product after passing the inspection.

[0044] It is recommended to take the above-mentioned compound isosorbide mononitrate pha...

Embodiment 2

[0065] clinical information

[0066] Select 71 patients with coronary heart disease and angina pectoris and divide them into two groups randomly. The treatment group consisted of 36 cases, including 19 males and 17 females, aged 50 to 74 years, with an average of 61.43±5.21 years, and the course of disease was six months to 15 years. There were 35 cases in the control group, including 17 males and 18 females, aged 49 to 75 years, with an average age of 57.38±5.64 years, and the course of disease was 5 months to 13 years. There was no significant difference in gender, age, and course of disease between the two groups before treatment ( P>0.05), comparable.

[0067] Diagnostic criteria

[0068] Western medicine diagnostic criteria

[0069] Refer to "Suggestions for the Diagnosis and Treatment of Unstable Angina Pectoris" by the Cardiovascular Disease Branch of the Chinese Medical Association.

[0070] Diagnosis and Syndrome Differentiation Standards of TCM

[0071] The TCM ...

Embodiment 3

[0083] typical embodiment

[0084] Qi, 41 years old, male, suffering from rheumatic heart disease and lung disease, paroxysmal angina, often chest tightness, shortness of breath, and waking up in the middle of the night, after taking the compound isosorbide mononitrate preparation of the present invention for one month, angina pectoris, chest tightness, waking up from sleep Only show effect once, through taking three courses for the treatment of (three months), all diseases disappear greatly. Follow up a case by regular visits to and there is no recurrence.

[0085] Sun Mou, 57 years old, female, self-reported stabbing pain in the left chest, sometimes causing pain in the back, dark coating and thready pulse, the syndrome belonged to blood stasis, dark tongue with greasy coating, deep and thready pulse, after taking the compound isosorbide mononitrate of the present invention Three courses of treatment of the preparation recovered from illness, and there was no recurrence in ...

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Abstract

The invention relates to a compound isosorbide mononitrate and a preparation technology thereof. The compound isosorbide mononitrate is prepared from the following raw materials according to parts by weight: 0.3 part of isosorbide mononitrate, 25 parts of astragalus mongholicus, 20 parts of ligusticum wallichii, 15 parts of antler and 12 parts of trichosanthes kirilowii maxim. According to a general medicine preparation method, a starch edible cellulose medical auxiliary material is added to obtain dosage forms, such as capsules, tablets, granules and the like. The compound isosorbide mononitrate composite disclosed by the invention treats both principal and secondary aspect of stenocardia, is nontoxic and harmless to the human body, has the advantages of no side effect, low cost and wide application prospect and is convenient to manufacture.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a Chinese and western medicine preparation for treating angina pectoris, in particular to the application of a compound medicine made of western medicine isosorbide mononitrate and Chinese herbal medicine in treating angina pectoris. Background technique [0002] In the field of clinical medicine today, cardiovascular system diseases have always been one of the diseases most likely to cause human death, and coronary heart disease and angina pectoris are the most common frequently-occurring diseases in cardiovascular system diseases. Angina pectoris is a clinical symptom caused by acute and temporary ischemia and hypoxia of the myocardium. Most of the patients are middle-aged and elderly people. It often occurs when some inducement exists. It is characterized by paroxysmal chest compression or The pain sensation is mainly located at the back of the sternum, and can ra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/481A61P9/10A61K31/34
Inventor 赵振桥聂昌盛张玉美徐平田王丽娟杜宾芳
Owner 仁和堂药业有限公司
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