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Application of safflower extract to prevention or treatment of neurodegeneration disease

A safflower extract, neurodegenerative technology, applied in the medical field of safflower extract, can solve problems such as no neurodegenerative diseases

Active Publication Date: 2012-07-04
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is worth noting that although there are many studies on safflower, it is generally used to improve cardiovascular and cerebrovascular circulation disorders, and there is no use of it for neurodegenerative diseases

Method used

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  • Application of safflower extract to prevention or treatment of neurodegeneration disease
  • Application of safflower extract to prevention or treatment of neurodegeneration disease
  • Application of safflower extract to prevention or treatment of neurodegeneration disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The preparation of embodiment 1 safflower extract

[0034] 1. Materials and methods

[0035] 1 material

[0036] 1.1.1 Reagents and medicines

[0037] Ethanol and methanol used for conventional extraction and separation are all analytical reagents, methanol for preparation is chromatographically pure reagents, produced by Beijing Chemical Factory, and acetonitrile is Fisher reagent (Fisher Scientific, Fairlawn, NJ). Deionized water is prepared from purified water through a Millipore Simplicity pure water system.

[0038] Macroporous resin (AB-8) was purchased from Nankai University, Tianjin; the gel SephadexLH-20 (25-100 μm) for the chromatography column was a product of Amersham Biosciences, and was repackaged by Beijing Branch; the ODS reverse-phase column filler (50 μm) was Merk Company production.

[0039] 1.1.2 Medicinal materials

[0040] Safflower is the dried petals of Carthamus rinctorius L., a plant of Compositae, which was purchased from China Medicinal ...

Embodiment 2

[0068] The preparation of embodiment 2 safflower extract granules

[0069] Get the safflower extract prepared in Example 1 (50% ethanol elution part, containing 6-hydroxykaempferol-3-oxyrutinoside, 6-hydroxypigenin-6-oxyglucose-7-oxyglucuronide , 6-hydroxykaempferol-3-oxyrutinoside-6-oxyglucoside) 3 grams, mixed with 5 grams of microcrystalline cellulose, 3 grams of lactose, 1 gram of cross-linked carboxymethyl cellulose sodium, with 3% poly Vitone ethanol solution (50% concentration) is a soft material made of adhesive, granulated through a 40-mesh sieve, dried at 60° C., granulated through a 30-mesh sieve to obtain safflower extract granules.

Embodiment 3

[0070] The preparation of embodiment 3 safflower extract tablet

[0071] Get the safflower extract prepared in Example 1 (50% ethanol elution part, containing 6-hydroxykaempferol-3-oxyrutinoside, 6-hydroxypigenin-6-oxyglucose-7-oxyglucuronide , 6-hydroxykaempferol-3-oxyrutinoside-6-oxyglucoside) 10 grams, mixed with 5 grams of lactose, 3 grams of pregelatinized starch, and 1 gram of sodium carboxymethyl starch, passed through a 80-mesh sieve twice, Mix evenly, use 3% PVP ethanol solution (concentration 50%) as a binder to make a soft material, pass through a 40-mesh sieve for granulation, dry at 60°C, pass through a 30-mesh sieve for granulation, add 0.1 g of micropowder silica gel, mix evenly, and press into tablets , 100 safflower extract tablets can be prepared.

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Abstract

The invention discloses an application of a safflower extract to prevention or treatment of a neurodegeneration disease. As proved by a large quantity of experiments, the safflower extract has a remarkable oxidative stress resisting function and can be used for effectively improving the behavioristic representation of a mouse suffering from chronic Parkinson's disease C57 induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and protecting the integrity of dopaminergic neuron form. As proved by an experimental result, the safflower extract has a definite pharmacological activity on the prevention or treatment of the neurodegeneration disease.

Description

technical field [0001] The invention relates to a new pharmacological application of safflower extract in treating neurodegenerative diseases, in particular to the application of safflower extract in preventing or treating Parkinson's disease, and belongs to the field of medical application of safflower extract. Background technique [0002] Parkinson's Disease (PD), also known as Parkinson's palsy, is a common neurodegenerative disease in middle-aged and elderly people. The main pathological change of PD is the degeneration of dopamine (DA) neurons in the substantia nigral compacta (SNc). When the neuron degeneration reaches a certain threshold, symptoms begin to appear, mainly manifested as resting tremor and bradykinesia And muscle rigidity, in addition to abnormal gait, posture, cognitive impairment and other symptoms. At present, the pathogenesis of Parkinson's disease is not very clear, and aging, environmental and genetic factors are all involved. [0003] The clini...

Claims

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Application Information

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IPC IPC(8): A61K36/286A61K31/7048A61P25/00A61P25/16C07H17/07A61K133/00
Inventor 蒲小平曲伟武倩叶敏
Owner PEKING UNIV
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