Photoacoustic and fluorescence dual-mode integrated tomography imaging system and imaging method

Abstract

The invention discloses a photoacoustic and fluorescence dual-mode integrated tomography imaging system and a photoacoustic and fluorescence dual-mode integrated tomography imaging method. The system comprises a modulation laser light source (1), a vibrating mirror (2), a sample rotary table (3), a filtering wheel (4), a gating intensified charge-coupled device (ICCD) camera (5), a photoacoustic detection acquisition module (6), a system control module (7), a computer (8), a data bus (9) and a control bus (10), wherein the vibrating mirror, the sample rotary table, the filtering wheel and the gating ICCD camera are positioned on the same straight line with the direction of lasers; the ultrasound transduction array normal direction of the photoacoustic detection acquisition module is perpendicular to the straight line to form a crossed vertical detection mode. According to the imaging method, light absorption distribution formed by photoacoustic tomography imaging is used as prior information for the reestablishment of fluorescence tomography imaging, and the positions of fluorophores, fluorescent yield and fluorescence lifetime parameters are reestablished by an iterative method. By the photoacoustic and fluorescence dual-mode integrated tomography imaging system and the photoacoustic and fluorescence dual-mode integrated tomography imaging method, the imaging complexity can be reduced, the cost of hardware can be saved, and the flexibility of the system and the reestablishing accuracy of the fluorescence tomography imaging can be improved.

Description

technical field [0001] The invention belongs to the technical field of imaging systems, in particular to a photoacoustic and fluorescent dual-mode integrated tomographic imaging system, which can perform high-precision reconstruction of light absorption parameters, fluorescent light source positions, fluorescent yields, and fluorescent lifetimes in complex organisms. It provides an effective means for detecting abnormalities at the cellular and molecular levels during the disease process, exploring the occurrence, development and metastasis of tumors, monitoring the treatment process, and evaluating the efficacy of drugs. Background technique [0002] Photoacoustic tomography is a non-destructive medical imaging method developed in recent years. It combines the high contrast characteristics of pure optical imaging and the high penetration depth characteristics of pure ultrasound imaging to provide high-resolution and high-contrast tissue imaging. Photoacoustic tomography is ...

AI Technical Summary

Problems solved by technology

Due to the use of femtosecond pulsed lasers, the system cost is high; the imaging object is placed in a water tank, and the system flexibility is low

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