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Cepharanthine hydrochloride injection, and preparation method and detection method for cepharanthine hydrochloride

A technology of fenugreek and injection, which is applied in the directions of pharmaceutical formulations, measuring devices, material inspection products, etc., can solve the problems of affecting the effect of treatment, low dissolution rate, affecting drug efficacy, etc., achieves a simple and feasible preparation process, and improves leukopenia. Symptoms, immune-boosting effect

Inactive Publication Date: 2012-05-30
SHANDONG DANHONG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, most of the domestically-applied stephadin preparations are oral pharmaceutical preparations with poor stability. After taking them, there are problems such as low dissolution rate, poor absorption, hepatic first-pass effect and low bioavailability, which affect the efficacy of the drug. , ultimately affecting the efficacy of the treatment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Take 1000ml of fresh water for injection, heat it to about 60°C, slowly add 10g of the stepherin hydrochloride, stir until it is completely dissolved, add fresh water for injection to 2000ml, mix well, and obtain the intermediate; determine the intermediate When the pH value is 4.0, filter through a 0.22 μm microporous membrane, seal, sterilize at 115° C. for 30 minutes, test, and obtain.

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Abstract

The invention relates to cepharanthine hydrochloride injection, and a preparation method and a detection method for the cepharanthine hydrochloride, discloses injection which utilizes cepharanthine hydrochloride as raw materials and comprises auxiliary materials received by pharmaceutics, and further discloses the detection method for the injection and clinical application of the injection. The cepharanthine hydrochloride injection is simple and feasible in preparation process and high in biological availability, is safe and effective, can remarkably reduce leucopenia of patients with malignancy due to chemotherapy and radiotherapy, and has excellent application prospect.

Description

technical field [0001] The invention relates to a stepahin hydrochloride injection, a preparation method and a detection method thereof, and belongs to the technical field of pharmaceutical preparations. [0002] Background technique [0003] Malignant tumors are one of the three major causes of death for human beings and a major health problem facing all countries in the world. According to statistics, the number of new cancer cases in the world today has exceeded 10 million and the death toll has exceeded 7 million. In China, the number of patients is 2.6 million and the death toll exceeds 1.7 million, and this number is still increasing. For many years, the medical and biological circles have been looking for effective cancer treatment methods. Although some progress has been made, they have not been completely resolved. [0004] At present, surgery, radiotherapy, chemotherapy and other methods are generally used to treat tumors. Radiotherapy and chemotherapy have ach...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/4741G01N30/02G01N33/15A61P7/00
Inventor 赵涛
Owner SHANDONG DANHONG PHARMA
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