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Channel ushering drug common achyranthes-containing traditional Chinese drug composition for improving bone marrow stem cell homing

A technology of bone marrow stem cells and compositions, applied in the field of traditional Chinese medicine compositions containing Achyranthes bidentata to achieve the effects of promoting bone repair and angiogenesis, low price, and delaying disease progression

Inactive Publication Date: 2013-05-01
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the body's self-repair response caused by injury, the number of BMSCs released into the peripheral blood is small, and the number of stem cells homing to the lesion is extremely small, and its self-repair effect is also extremely limited.

Method used

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  • Channel ushering drug common achyranthes-containing traditional Chinese drug composition for improving bone marrow stem cell homing
  • Channel ushering drug common achyranthes-containing traditional Chinese drug composition for improving bone marrow stem cell homing
  • Channel ushering drug common achyranthes-containing traditional Chinese drug composition for improving bone marrow stem cell homing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1 Chinese medicine composition (water decoction) containing Achyranthes bidentata and its preparation method

[0024] Achyranthes 15 Astragalus 30 Angelica 15 Chuanxiong 15

[0025] Red peony 12, peach kernel 15, safflower 15, earthworm 15

[0026] Guizhi 15 Papaya 15 Clematis 15

[0027] Weigh and mix the above raw materials according to the prescription amount, add 5 times the weight of water to the raw materials, soak for 1.5 hours, decoct for 30 minutes, filter; add 3 times the weight of water, decoct for 20 minutes, filter ; Merge the two filtrates to make a water decoction.

Embodiment 2

[0028] Example 2 Chinese medicine composition (water decoction) containing Achyranthes bidentata and its preparation method

[0029] Achyranthes 10 Astragalus 15 Angelica 10 Chuanxiong 10

[0030] Red peony 6, peach kernel 10, safflower 10, earthworm 10

[0031] Guizhi 10 Papaya 10 Clematis 10

[0032] Weigh and mix the above raw materials according to the prescription amount, add 5 times the weight of water to the raw materials, soak for 1.5 hours, decoct for 30 minutes, filter; add 3 times the weight of water, decoct for 20 minutes, filter ; Merge the two filtrates to make a water decoction.

Embodiment 3

[0033] Example 3 Traditional Chinese medicine composition (water decoction) containing Achyranthes bidentata and its preparation method

[0034] Achyranthes 20 Astragalus 45 Angelica 20 Chuanxiong 20

[0035] Red peony 18, peach kernel 20, safflower 20, earthworm 20

[0036] Guizhi 120 Papaya 20 Clematis 20

[0037] Weigh and mix the above raw materials according to the prescription amount, add 7 times the weight of water to the raw materials, soak for 1 hour, decoct for 30 minutes, filter; add 5 times the weight of water for the dregs, decoct for 20 minutes, filter ; Merge the two filtrates to make a water decoction.

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Abstract

The present invention provides a channel ushering drug common achyranthes-containing traditional Chinese drug composition for improving bone marrow stem cell homing. The traditional Chinese drug composition is prepared from the following raw material drugs, wherein the raw material drugs comprise, by weight, 10-20 parts of common achyranthes, 15-45 parts of mongolian milkvetch root, 10-20 parts of angelica, 10-20 parts of szechwan lovage rhizome, 6-18 parts of red peony root, 10-20 parts of peach seed, 10-20 parts of safflower, 10-20 parts of lumbricus, 10-20 parts of cassiabarktree twig, 10-20 parts of common floweringquine fruit, and 10-20 parts of clematis chinensis osbeck. According to the present invention, the channel ushering drug common achyranthes-containing traditional Chinese drug composition of the present invention has the effect of improvement of autologous bone marrow stem cell homing so as to improve bone repair and vascular regeneration inside the femur head, and provides significant effects for delaying of disease developments of femur head necrosis and other osteoarticular diseases. In addition, the traditional Chinese drug composition has characteristics of lowtoxic and side-effects and low price.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition and application thereof, in particular to a traditional Chinese medicine composition containing the medicine Achyranthes bidentata for promoting the homing of bone marrow stem cells. Background technique [0002] Femoral head necrosis is a common refractory disease in orthopedics and traumatology with high morbidity and disability rate. At present, the number of patients in my country is about 5 to 7.5 million, and the number of new patients is 100,000 to 200,000 every year. There are two types of treatment for femoral head necrosis, non-surgical and surgical, but the overall curative effect is not satisfactory. Therefore, seeking effective treatment methods is still a direction for researchers to explore. [0003] Stem cell therapy for osteonecrosis of the femoral head is a treatment method that has emerged in recent years, but at present, most of the research is focused on MSCs tran...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/732A61P19/08A61K35/64A61K35/62
Inventor 林娜陈卫衡孔祥英王荣田田能
Owner INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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