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Preparation method of novel biochemical particles

A granule and biochemical technology, applied in the field of drug preparation, can solve the problems of affecting the application, large daily dosage of patients, and backwardness, and achieve the effect of reducing the dosage

Inactive Publication Date: 2012-04-04
SUZHOU PAITENG BIOLOGICAL MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the prior art, the preparation of Xinhua granules adopts the method of decocting in water. The process is rough and outdated, and there are many impurities, which leads to excessive daily dosage of patients and is inconvenient to take, which seriously affects the clinical application of this product.

Method used

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  • Preparation method of novel biochemical particles

Examples

Experimental program
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Effect test

Embodiment 1

[0082] Take 240g of angelica, 90g of Chuanxiong, 24g of peach kernel, 15g of licorice (burnt), 15g of dried ginger (charcoal), 15g of safflower, crush them, and add them to CO 2 In the supercritical extractor, ethanol is used as an entrainer, the entrainer accounts for 1% by volume of the total extraction solvent, the extraction pressure is 15MPa, the temperature is 30°C, CO 2 The flow rate is 1ml / g crude drug·min, the extraction time is 120min, and the supercritical extract is obtained for later use; take 300g of motherwort, pulverize it, add 1.5L of hydrochloric acid aqueous solution with a pH value of 3-4, and put it into a microwave extraction device for microwave extraction. 300W, extract 2 times, 3 minutes each time, combine the extracts, filter, concentrate, absorb through a D102 macroporous adsorption resin column, elute with 60% ethanol, collect 3 times the column volume of the eluate, The ethanol was recovered under reduced pressure, concentrated, and dried to o...

Embodiment 2

[0090] Take 240g of angelica, 90g of Chuanxiong, 24g of peach kernel, 15g of licorice (burnt), 15g of dried ginger (charcoal), 15g of safflower, crush them, and add them to CO 2In the supercritical extractor, ethanol is used as an entrainer, the entrainer accounts for 1% by volume of the total extraction solvent, the extraction pressure is 15MPa, the temperature is 50°C, CO 2 The flow rate is 3ml / g crude drug·min, the extraction time is 150min, and the supercritical extract is obtained for use; take 300g of motherwort, grind it, add 1.5L of hydrochloric acid aqueous solution with a pH value of 3-4, and put it into a microwave extraction device for microwave extraction. 600W, extract 2 times, 8 minutes each time, combine the extracts, filter, concentrate, absorb through the AB-8 macroporous adsorption resin column, elute with 80% ethanol, and collect 8 times the volume of the eluted column. Liquid, ethanol was recovered under reduced pressure and concentrated, dried, Leonurus e...

Embodiment 3

[0097] Take 240g of angelica, 90g of Chuanxiong, 24g of peach kernel, 15g of licorice (burnt), 15g of dried ginger (charcoal), 15g of safflower, crush them, and add them to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 1%, the extraction pressure is 20MPa, the temperature is 40°C, CO 2 The flow rate is 2ml / g crude drug·min, the extraction time is 130min, and the supercritical extract is obtained for use; take 300g of motherwort, grind it, add 1.5L of hydrochloric acid aqueous solution with a pH value of 3-4, and put it into a microwave extraction device for microwave extraction. 500W, extract 2 times, 6 minutes each time, combine the extracts, filter, concentrate, absorb through a D101 macroporous adsorption resin column, elute with 70% ethanol, collect 5 times the column volume of the eluate, reduce The ethanol was recovered under pressure, concentrated, and dried to obtain t...

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Abstract

The invention relates to a preparation method of novel biochemical particles. The method comprises the following steps of: smashing six types of medicinal materials, including Chinese angelica, szechuan lovage rhizome, peach kernel, liquoric root (processed), dried ginger (carbonized) and safflower, adding the powder into a CO2 supercritical extractor, and treating with ethanol serving as an entrainer to obtain a supercritical extract for later use; smashing motherwort herb, adding 1.5 liters of hydrochloric acid aqueous solution, putting into a microwave extraction device for performing microwave extraction, combining extraction liquids, filtering, concentrating, adsorbing with a porous adsorbent resin column, eluting with ethanol, collecting an eluent, recovering ethanol under reduced pressure, concentrating and drying to obtain a motherwort herb extract for later use; and mixing the supercritical extract and the motherwort herb extract with a mixture consisting of brown sugar and starch in the mass percentage ratio of 1:1 to obtain particles. The novel biochemical particles prepared with the method are convenient to take. The invention further relates to application of the novel biochemical particles to preparation of a medicament for treating hyperplasia of mammary glands.

Description

technical field [0001] The invention relates to a preparation method of medicine, in particular to a preparation method of traditional Chinese medicine. Background technique [0002] Xinhuahua Granules are composed of 7 herbs including motherwort, angelica, peach kernel, chuanxiong and safflower. It is recorded in the fifth volume of traditional Chinese medicine preparations in the "Ministerial Standards", which can promote blood circulation, remove blood stasis and relieve pain. It can't be used for postpartum lochia and abdominal pain, and it can also be used for vaginal bleeding and menorrhagia caused by birth control. [0003] In the prior art, there is no report on the treatment of mammary gland hyperplasia by Xinhuahua granules. [0004] Modern research shows that Xinshenghua Granules have a mild uterine contraction effect; obvious hemostatic effect; good anti-inflammatory effect, which can significantly reduce intrauterine inflammation; and good analgesic effect. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K9/16A61P15/14
Inventor 王峰王琳张发成
Owner SUZHOU PAITENG BIOLOGICAL MEDICAL TECH
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