Pharmaceutical composition for treating nephrosis and preparing process thereof

Abstract

The invention relates to a pharmaceutical composition for treating nephrosis and a preparing process thereof, belonging to the field of traditional Chinese medicines. The pharmaceutical composition for treating nephrosis is prepared from the following medicinal materials by weight: 30 to 50 parts of radix astragali, 30 to 50 parts of motherwort, 10 to 30 parts of imperata rhizome, 10 to 30 parts of polygonum aviculare, 10 to 30 parts of dianthus superbus, 10 to 30 parts of herba cephalanoploris, 5 to 15 parts of pyrrosia lingua, 5 to 15 parts of garden burnet root,10 to 30 parts of rhubarb root and 2 to 4 parts of licorice.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating nephropathy and a preparation method thereof, belonging to the field of traditional Chinese medicines. Background technique [0002] Nephritis is glomerular damage caused by a variety of reasons, which can cause changes in the permeability of glomerular capillaries, resulting in varying degrees of proteinuria, hematuria, leukocyturia, and casturia. Chinese medicine believes that this is related to wind, water dampness, heat, and fatigue. [0003] As a hospital preparation, Shenyanqing Tablet has been used in Beidaihe Sanatorium of Beijing Military Region since 1979 and obtained the hospital preparation approval, and has accumulated certain clinical data during its use in the hospital. The prescription and preparation method of Shenyanqing Tablets are: Astragalus 800g, Motherwort 800g, Imperatae 400g, Limegrass 400g, Qumai 400g, Thistle 400g, Shiwei 160g, Burnet Charcoal 120g, Rhubarb 4...

AI Technical Summary

Problems solved by technology

[0005] The traditional technology of Shenyanqing Tablets adopts the technology of water extraction and concentration for direct preparation, which basically follows the technology of traditional Chinese medicine decoction. Although this technology can retain the medicinal ingredients to a certain extent, its disadvantages are also obvious: ①Traditional decoction water The extraction process without any subsequent refining treatment makes the product have a high paste yield (the dry paste yield is more than 30%), and the patient takes a large amount (24 tablets per day), and chronic nephritis requires long-term medication. It is very difficult for patients to take it; ②The use of sugar-coated tablet technology not only greatly increases the size of the tablet, but also is not conducive to taking it by diabetic patients, especially in recent years, the diabetic nephropathy patients whose incidence has continued to rise have to be restricted; ③Extraction The process does not consider the characteristics of each medicinal taste in the prescription, so that the extraction of functional components is not complete. For example, according to literature reports, the main functional components of thistle in the prescription are flavonoids, and the main functional components of rhubarb are anthraquinone, naphthoquinone and flavonoids. , these types of compounds have better alcohol solubility, theoretically should be extracted with ethanol, but this process uses water extraction, so that the transfer rate of functional components is low and the extraction is not complete

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