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Application of Chinese herbal medicine shrubby sophora extract to preparation of weight losing and lipid lowering medicament or medicament with lipase activity suppression effect

A technology of Chinese herbal medicine and lipase, applied in the direction of drug combination, medical formula, plant raw materials, etc., can solve the problems of unclear active ingredients of Chinese herbal medicine, unclear pharmacological mechanism, and failure of Chinese herbal medicine to go global

Inactive Publication Date: 2012-03-14
BEIJING WBL PEKING UNIV BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to limitations such as unclear active ingredients and pharmacological mechanisms of Chinese herbal medicines, traditional Chinese herbal medicines cannot go to the world. So far, there is no weight-loss drug with independent intellectual property rights in my country.

Method used

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  • Application of Chinese herbal medicine shrubby sophora extract to preparation of weight losing and lipid lowering medicament or medicament with lipase activity suppression effect
  • Application of Chinese herbal medicine shrubby sophora extract to preparation of weight losing and lipid lowering medicament or medicament with lipase activity suppression effect
  • Application of Chinese herbal medicine shrubby sophora extract to preparation of weight losing and lipid lowering medicament or medicament with lipase activity suppression effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Embodiment 1: the preparation of Scutellaria baicalensis water extract

[0061] Take Scutellaria baicalensis slices, prefabricate, pulverize; add 5 times the volume of deionized water, boil for 30 minutes, filter, and take the filtrate; use conventional methods to make conventional dosage forms for the preparation of lipase inhibitors.

Embodiment 2

[0062] Example 2: Preparation of Scutellariae Alcohol Extract

[0063] Scutellaria baicalensis slices are taken, prefabricated, and pulverized; 5 times the volume of 75% ethanol is added, ultrasonically extracted for 60 minutes, filtered, and the filtrate is obtained; conventional dosage forms are prepared by conventional methods for the preparation of lipase inhibitors.

Embodiment 3

[0064] Embodiment 3: the preparation of Pu'er tea water extract

[0065] Take Pu'er tea decoction pieces, prefabricate, pulverize; add 10 times the volume of deionized water, boil for 60 minutes, centrifuge at 4000r / min for 20 minutes, and take the supernatant; use conventional methods to make conventional dosage forms for the preparation of lipase inhibitors.

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Abstract

The invention discloses application of Chinese herbal medicine shrubby sophora extract to preparation of a weight losing and lipid lowering medicament or a medicament with lipase activity suppression effect, solves the problems of low efficiency and high side effect in the conventional clinical weight losing medicament, particularly traditional Chinese medicine, and provides the weight losing andlipid lowering medicament which has the advantages of clear mechanism, scientific target point, small side effect and high clinical effectiveness.

Description

technical field [0001] The invention relates to the application of Chinese herbal medicine Sophora flavescens extract in the preparation of weight-loss and lipid-lowering medicine or the medicine with lipase activity inhibitory effect. Background technique [0002] Metabolic syndrome (MS) mainly includes risk factors such as obesity, impaired glucose tolerance, dyslipidemia, and hypertension. The incidence of diabetes (Diabetes mellitus, DM) and cardiovascular disease in MS patients is often several times that of the normal population. MS has seriously endangered human's physical and mental health and has become a worldwide public health problem, but so far our understanding of MS is very limited. Preliminary studies have confirmed that among many causes, obesity has a particularly close relationship with MS, and is a key factor and core link in the onset and development of MS. With the development of economy, the improvement of people's living standard and the change of l...

Claims

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Application Information

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IPC IPC(8): A61K36/489A61K36/855A61K36/804A61K36/704A61K45/00A61P3/04A61P3/06
Inventor 段震文郭树仁闫雪秋
Owner BEIJING WBL PEKING UNIV BIOTECH
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