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Preparation and application of traditional Chinese medicine compound extract with whitening and freckle removing effects

An extract and compound technology, which is applied in the field of Chinese medicine compound extracts, can solve the problems of many adverse reactions, no treatment plan, and long course of treatment.

Inactive Publication Date: 2013-07-10
HARBIN NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional Chinese medicine treatment of chloasma still has the disadvantages of slow curative effect, low cure rate, long course of treatment, inconvenient long-term taking of traditional Chinese medicine, etc., which affects the compliance of treatment.
[0007] In a word, there are many medicines and methods for treating chloasma in traditional Chinese and western medicine, but either because the curative effect is too slow, or because of too many adverse reactions, there has not been a treatment plan that is effective, safe, recognized, and satisfactory to both doctors and patients. Very inconsistent with actual clinical needs

Method used

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  • Preparation and application of traditional Chinese medicine compound extract with whitening and freckle removing effects
  • Preparation and application of traditional Chinese medicine compound extract with whitening and freckle removing effects
  • Preparation and application of traditional Chinese medicine compound extract with whitening and freckle removing effects

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1 (TQW inhibits tyrosinase activity and melanin production experimental research)

[0030] 1 Experimental materials

[0031] Mouse B16 melanoma cells (purchased from Shanghai Institute of Cells, Chinese Academy of Sciences); arbutin (purchased from Sigma); DMEM medium (purchased from Gibco); fetal bovine serum (purchased from Billab); trypsin (purchased from in Billab Company); phosphate buffered saline (purchased in Beijing Zhongshan Jinqiao Co., Ltd.); double antibody (purchased in Billab Company); Dopa (purchased in Sigma Company); TritonX-100 (purchased in Sigma Company); MTT (purchased in Billab Company); DMSO (purchased from Sigma Company); microplate reader (Thermoelectric Shanghai Instrument Co., Ltd.).

[0032] 2 reagent preparation

[0033] Take arbutin and dilute it with DMEM medium to the concentration required for the experiment.

[0034]Take TQW, dissolve it in a small amount of absolute ethanol, and then dissolve it in DMEM medium to make 1mg / m...

Embodiment 2

[0062] Example 2 (Experimental research on the inhibitory effect of TQW on UVB-induced guinea pig skin pigmentation)

[0063] 1 Experimental instruments, reagents and experimental animals

[0064] UVB ultraviolet phototherapy instrument (Sigma company); 0.1% 8-methoxypsoralen (8-MOP) tincture (Sigma company); Vitamin C tablet (Shijiazhuang Ouyi Pharmaceutical Co., Ltd.); Ordinary grade healthy pure white guinea pig 90 One, female, weighing 250-320g; externally-applied drugs containing different concentrations of TQW were prepared with common matrix, and intragastric drugs containing different concentrations of TQW were prepared by suspension in distilled water.

[0065] 2UVB-induced pigmentation model replication and administration

[0066] Take 3 separated areas (2×2cm) on the back of each guinea pig 2 ), use curved scissors to cut off the long hair at the center of the back of the guinea pig, shave the short hair with an electric shaver, and use the SS-04B ultraviolet ligh...

Embodiment 3

[0092] Embodiment 3 (preparation of tablet)

[0093] In parts by weight, take 5-9 parts of TQW, add 1-2 parts of talcum powder, 1-2 parts of starch, 1-2 parts of carboxymethyl starch sodium, spray 95% ethanol to moisten, wet granulate, dry, add 0.5-1% magnesium stearate, mixed evenly, and compressed into tablets; adding 15% Opadry coating solution for coating, and then coating with 7% weight gain to obtain film-coated tablets.

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PUM

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Abstract

The invention relates to a traditional Chinese medicine compound extract with whitening and beverage removing effects. The traditional Chinese medicine compound extract is an extract prepared by using ten kinds of traditional Chinese medicine such as patrinia villosa juss, shinyleaf yellowhorn kernels, cortex dictamni, hairyvein agrimony, rhodiola root, cassia seeds, semen boitae, golden buckwheat rhizome, peppermint, liquorice and the like as raw materials and adopting the carbon dioxide supercritical extraction technology and the macroporous absorbent resin enrichment technology at certain technological parameters. The extract has an obvious tyrosinase activity inhibition effect and a melanin generation inhibition effect and can be directly and safely applied to the preparation of cosmetics and external use medicine preparations with the whitening and beverage removing effects.

Description

technical field [0001] The present invention relates to a compound extract of traditional Chinese medicine, in particular to a method of adopting carbon dioxide supercritical extraction technology and macroporous adsorption resin enrichment technology, which is composed of Patrinia radiata, Xanthania sorbifolium seed kernel, fresh bark, Agrimony, red Sedum, cassia seed, cypress kernel, golden buckwheat, mint, licorice as raw material extract, the extract has obvious inhibitory effect on tyrosinase activity and melanin production. The invention also relates to the application of the extract in the preparation of whitening and anti-ban medicinal preparations, health food and cosmetics. Background technique [0002] Heart of beauty in everyone. With the improvement of living standards, people's requirements for quality of life are getting higher and higher, and people pay more and more attention to the natural whitening of the skin, and the face is particularly important. Chl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/97A61K36/77A61P17/00A61Q19/02A61Q19/00A23L1/29A23L33/00
Inventor 耿放刘海洋赵旭任燕冬周琦祁永华张宁
Owner HARBIN NORMAL UNIVERSITY
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