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Device for aspirating fluids

An internal flow and device technology, applied in the direction of inhalers, suction devices, drug devices, etc., can solve the problems of limiting suction rate, easy to kink failure, etc.

Inactive Publication Date: 2012-02-22
ISCI INTERVENTIONAL CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The physical size of such a small microcannula also significantly limits the achievable suction rate and also makes the device prone to kink failure during retinal penetration

Method used

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  • Device for aspirating fluids
  • Device for aspirating fluids
  • Device for aspirating fluids

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0082] Example 1: Suction device

[0083] A 25 gauge stainless steel hypotube (Small Parts, Inc) was used as the main rod. Two holes were drilled at a distance of 0.05 inches (1.27 mm) and 0.12 inches (3.05 mm) from the proximal edge of the hypotube. A third hole was drilled at a distance of 1.15 inches (29.21 mm) from the distal edge of the hypotube. A second 25 gauge stainless steel hypotube (Small Parts, Inc) was laser welded at an angle to provide a flow path to the third hole.

[0084] Polyimide tubing (Microlumen, Inc) with a lumen of 100 microns (0.0039 inches), an outer diameter of 125 microns (0.0049 inches) and a length of 0.25 inches (6.35 mm) was inserted into a lumen of 165 microns (0.006 inches). , a distance of 0.05 inches (1.27 mm) within another polyimide tube with an outer diameter of 210 microns (0.0082 inches) and a length of 1.45 inches (36.83 mm). Cyanoacrylate polymer (Loctite 4011, Loctite, Inc) was applied to bond the two polyimide tubes together. ...

example 2

[0088] Example 2: Laboratory test with suction device

[0089] Human cadaver eyes were obtained from eye banks. Removal of the cornea, iris, lens, and vitreous provides access to the retina from within the eyeball without significantly disrupting retinal tissue, while also allowing the retina to retain its original physiological attachment. Experiments were performed using prototypes using existing post-mortem retinal detachments or retinal detachments induced by injection of phosphate-buffered saline into the subretinal space with a needle inserted through the exterior of the eyeball.

[0090] The suction device from Example 1 was inserted into the subretinal space and a vacuum was applied in the range of 300 mm Hg to 600 mm Hg. Retinal tissue can be seen trapped by the outer annular vacuum, and fluid and tissue debris can be seen migrating towards the microneedles. The device suctions the SRF until reapposition of the photosensitive retina and underlying RPE and choroid oc...

example 3

[0091] Example 3: Suction device with outer tissue shield

[0092]25 gauge stainless steel hypotube (Small Parts, Inc) was used as the main rod and was cut to a length of 1.25 inches (31.75 mm). A 0.25 inch (6.35 mm) length of polyimide tubing with an inner diameter of 0.0044 inch (0.112 mm) and an outer diameter of 0.0056 inch (0.142 mm) was used as the microneedle. Cyanoacrylate adhesive (Loctite 4011, Loctite, Inc.) was used to incorporate the microneedles within the stem so that the 0.20" microneedles protruded from the stem. UV-cured epoxy (Loctite 3341, Loctite, Inc. .) Applied within a 360 degree disc shape around the microneedle near the microneedle distal opening to act as a tissue shield. The disc has a diameter of 0.012" (0.305mm).

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Abstract

Surgical devices are provided for aspiration of the subretinal fluid (SRF) of the eye in a retinal detachment that allows re-apposition of the sensory retina to the underlying RPE. The device is connected to a vacuum source, introduced into the posterior chamber through a sclerostomy port and placed against the detached retinal tissue. The device pulls on and captures the surface of the sensory retina, causing a micro needle to pierce through the tissue. As the sensory retina is captured and held in place by the vacuum, a protected pocket is created and the tissue is prevented from folding onto itself and occluding the micro needle tip.

Description

[0001] related application [0002] This application claims priority to commonly assigned US Patent Application No. 12 / 359,169, filed January 23, 2009, which is hereby incorporated by reference in its entirety for all purposes. technical field [0003] The present invention relates to a device for aspiration of subretinal fluid (SRF) in eyes with retinal detachment, which allows reattachment of the photosensitive retina to the underlying retinal pigment epithelium (RPE). Background technique [0004] Retinal detachment occurs when subretinal fluid (SRF) causes separation between the light-sensitive retina and the supporting outer tissues, including the retinal pigment epithelium (RPE) and choroid. Typically, retinal detachment results when a full-thickness defect in the photosensitive retina allows SRF to enter the subretinal space. This SRF arises from the liquefied vitreous humor (the clear colloid that occupies the posterior segment of the eye), and the full-thickness de...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F9/007A61F2/958
CPCA61F9/00727A61F9/00736A61M2210/0612A61M1/85A61F9/007A61M1/00A61M15/00A61M27/00
Inventor T.S.常F.候S.R.康斯顿R.K.亚马莫托
Owner ISCI INTERVENTIONAL CORP
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