New process method for preparing Guifudihuang capsule

The technology of Guifu Rehmannia glutinosa and the process method is applied in the directions of capsule delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., which can solve problems such as difficulty in swallowing and capsule floating, and achieve the effect of reducing the dosage and improving the quality standard of the finished product.

Inactive Publication Date: 2014-12-10
TIANJIN DANXI TCM INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Guifudihuang capsules prepared by the original method, 7 capsules each time, twice a day, are difficult for the elderly to accept. On the one hand, it is difficult to swallow, and on the other hand, too many capsules float in the stomach, causing a feeling of fullness.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0023] Implementation example: make 1000 capsules,

[0024] Prescription:

[0025] Cinnamon 155.54g Aconite (made) 155.54g Rehmannia glutinosa 1244.39g Wine cornus 622.16g

[0026] Cortex Moutan 466.62g Yam 622.16g Poria 466.62g Alisma 466.62g

[0027] operate:

[0028] Take 466.62g of coarse powder peony cortex, add 4666.2ml of water, soak for 3 hours, steam distill, collect 1400ml of distillate within 2.5 to 3 hours, add 70g of NaCl to the distillate, put it in the refrigerator (refrigerated) overnight, precipitate white crystals, filter , washed with cold water, dried below 45°C, and set aside, and the dregs of Moutan cortex are collected in a separate device for use;

[0029] Take 622.16g of coarse powder Chinese yam, 466.62g of poria cocos, add 5450ml of water to reflux and extract 3 times, each time for 0.5 hours, filter the extract, and concentrate under reduced pressure (below 70°C, 0.09MPa) to a thick paste (D 60° =1.20~1.24) standby;

[0030] Take 622.16g cornu...

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PUM

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Abstract

The invention relates to a new process method for preparing Guifudihuang capsule. The Guifudihuang capsule comprises 1-2 parts of cassia bark, 1-2 parts of prepared common monkshood daughter root (prepared), 8-16 parts of prepared rehmannia root, 4-8 parts of wine-prepared fructus corni, 3-6 parts of tree peony root-bark, 4-8 parts of common yam rhizome, 3-6 parts of tuckahoe and 3-6 parts of oriental waterplantain tuber. The process method provided by the present invention has the following advantages that: according to main active ingredients and physical and chemical properties of various drugs, different solvents for the drugs are adopted to carry out extraction; a D101 macroporous adsorption resin column is adopted to carry out separation, purification and impurity removing, such that the taking amount of the capsule is substantially reduced, wherein the taking amount of the capsule provided by the present invention is reduced by 85% than the taking amount of the capsule prepared through the existing process method; animal experiments show that: the capsule provided by the present invention provides a significant treatment effect for kidney yang deficiency syndrome; long-term toxicity tests show that: the clinical application of the capsule provided by the present invention is safe, the quality control standard of the capsule provided by the present invention is substantially improved compared to the taking amount of the capsule prepared through the existing process.

Description

Technical field: [0001] The invention belongs to a traditional Chinese medicine preparation, in particular to a new process for preparing Guifu Dihuang Capsules. Background technique: [0002] Guifu Dihuang Pills originated from Jinkuishenqi Pills of medical sage Zhang Zhongjing. It is the ancestral prescription for invigorating the kidney. ~8 parts, 3~6 parts of Moutan cortex, 4~8 parts of yam, 3~6 parts of Poria cocos, 3~6 parts of Alisma. It has the effect of warming and tonifying kidney yang. Insufficient kidney yang, soreness and coldness of the waist and knees, edema of the limbs, difficulty in urinating or excessive urination, dyspnea and cough due to phlegm retention, and quenching thirst. This prescription has been around for nearly two thousand years, and it has been used for a long time due to its definite curative effect. [0003] Deficiency of kidney qi and yang is a natural law of people. With age, the deficiency of kidney qi and yang becomes more and more s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8945A61K9/48A61P13/12
Inventor 孔伶俐魏吉城
Owner TIANJIN DANXI TCM INST
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