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High-purity folium ginkgo composition, preparation including same and preparation method thereof

A technology of ginkgo biloba leaves and a composition is applied in the field of preparation of traditional Chinese medicine extracts, which can solve the problems of inability to remove impurities well, poor elution ability of total flavonoids, unsatisfactory effect of removing impurities, etc. Good entry and removal effect and less impurity effect

Active Publication Date: 2014-04-16
HEILONGJIANG ZBD PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] In the above method, the traditional polyamide resin was used in the preparation of the total flavonoid glycoside extract A of Ginkgo biloba. The impurity removal effect is not satisfactory; the second, when the polyamide resin is eluted, it is first eluted with water, and then eluted with 60% ethanol. With 60% ethanol eluting, the elution ability to total flavonoids is poor, and the total flavones content that obtains is lower; The 3rd, because the above-mentioned steps cause the total flavones purity that finally obtains is not high, therefore increased with acetone, ethyl acetate Processing steps that increase the risk of introducing new impurities

Method used

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  • High-purity folium ginkgo composition, preparation including same and preparation method thereof
  • High-purity folium ginkgo composition, preparation including same and preparation method thereof
  • High-purity folium ginkgo composition, preparation including same and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Embodiment 1: Ginkgo biloba composition

[0064] 1. Extraction method:

[0065] 1) Ginkgo biloba powder was extracted with ethanol for 3 times, the first time added 5 times the amount of 95% ethanol to soak for 0.5 hours and then refluxed for 3 hours, the second time added 3 times the amount of 90% ethanol to extract for 2 hours, and the third time added Extract with 2 times the amount of 90% ethanol for 2 hours, filter, recover the ethanol under reduced pressure until there is no alcohol smell, concentrate to contain crude drug 1g / ml, add 4 times the amount of water to dilute, cool, stand below 10°C for 12 hours, filter, Talc powder is used as a filter aid to pass through the ADS-17 resin column at a flow rate of 1BV / h, firstly wash with purified water with 2 times the amount of resin at a flow rate of 1BV / h, and then wash with 70% ethanol with 2 times the amount of resin at a flow rate of 1BV / h Remove, and start to collect the eluent when the active ingredient flows ...

Embodiment 2

[0087] Embodiment 2: Ginkgo biloba composition

[0088] 1. Extraction method:

[0089] 1) Ginkgo biloba powder was extracted with ethanol for 3 times, the first time added 6 times the amount of 90% ethanol to soak for 0.5 hours and then refluxed for 3 hours, the second time added 4 times the amount of 85% ethanol to extract for 2 hours, the third time added Extract with 3 times the amount of 85% ethanol for 1 hour, filter, recover the ethanol under reduced pressure until there is no alcohol smell, concentrate to contain crude drug 1.5g / ml, add 6 times the amount of water to dilute, cool to below 10°C and let stand for 8 hours, filter , talcum powder filter aid, pass through the ADS-17 resin column at a flow rate of 1.2BV / h, first wash with purified water with 3 times the amount of resin at a flow rate of 1.2BV / h, and then use 70% ethanol with 2 times the amount of resin at 1.2BV / h The flow rate of h is eluted, and the eluent is collected when the active ingredient flows out, ...

Embodiment 3

[0094] Embodiment 3: Ginkgo biloba composition

[0095] 1. Extraction method:

[0096] 1) Ginkgo biloba coarse powder was extracted with ethanol for 3 times, first time added 4 times the amount of 94% ethanol to soak for 0.5 hours and then refluxed for 3 hours, added 3 times the amount of 88% ethanol for the second time to extract for 2 hours, and added for the third time Extract with 2 times the amount of 85% ethanol for 1 hour, filter, recover the ethanol under reduced pressure until there is no alcohol smell, concentrate to contain crude drug 1.2g / ml, add 4.8 times the amount of water to dilute, cool to below 10°C and let stand for 24 hours, filter , talcum powder filter aid, pass through the ADS-17 resin column at a flow rate of 1BV / h, first wash with 2.5 times the amount of resin purified water at a flow rate of 1BV / h, and then use 1.5 times the amount of resin 70% ethanol at a flow rate of 1BV / h After elution, the eluent is collected when the effective components flow o...

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Abstract

The invention relates to a high-purity folium ginkgo composition, a preparation including same and a preparation method thereof. The composition comprises ginkgo flavonoids refined content and ginkgo total lactone refined content according to the weight ratio of (3-9):1. The content of total ginkgolic acid in the composition is not beyond 3%. Flavonoids and total lactone have high purity and less impurity. Injection prepared from the composition is light coloured, safe and effective and has proper active ingredient proportion and steady quality.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine extract, in particular to a ginkgo leaf composition and a preparation method thereof. Background technique [0002] Ginkgo biloba is a perennial deciduous tree of the Ginkgo family Ginkgo family. It has existed on the earth for more than 200 million years and is known as "natural living fossil". [0003] Ginkgo biloba is also known as Gongsun tree, ginkgo tree, etc. Its seeds, ginkgo, have a long history in my country as a traditional Chinese medicine for relieving cough, relieving asthma, reducing stool, and stopping turbidity. Its leaves, Ginkgo biloba, also known as ginkgo leaves, are bitter, sweet and astringent, flat in nature and slightly poisonous. The chemical composition of Ginkgo biloba is very complex. More than 170 compounds have been found so far, mainly flavonoids, terpenes, alcohols, alkaloids, polyisoprenes, polysaccharides and other active ingredients with...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/365A61K31/352A61K36/16A61P9/10A61P25/28A61P11/00A61P9/00A61K127/00
Inventor 方同华
Owner HEILONGJIANG ZBD PHARMA
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