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Positron emission tomography and optical tissue imaging

A technology of positron emission and tomography, which is applied in the field of combined PET and optical imaging systems, can solve the problems of increasing morbidity, prolonging the time of being anesthetized, increasing the time of surgery, etc., so as to reduce the total time and reduce the number of times Effect

Inactive Publication Date: 2011-12-07
JEFFERSON SCI ASSOCS LLC
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  • Claims
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Problems solved by technology

For the patient, time lost during this procedure results in increased surgical time and prolonged anesthesia, which leads to increased morbidity
Increased surgical time also results in an overall higher cost of the procedure

Method used

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  • Positron emission tomography and optical tissue imaging
  • Positron emission tomography and optical tissue imaging
  • Positron emission tomography and optical tissue imaging

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Embodiment Construction

[0010] Positron emission tomography with F-18 fluorodeoxyglucose (FDG) has proven to be a valuable tool for imaging various cancers. Many carcinomas display increased glucose metabolism compared to normal tissues. When FDG is injected intravenously, the FDG concentrates in the tumor so that the tumor can be imaged. In a protocol used in conjunction with the imaging system of the present invention, the patient is injected with a small amount of positron-emitting radiopharmaceutical, such as FDG, one hour before surgery. When the surgeon has removed the cancerous portion, he or she will use dye to mark the resected tissue and the operating table to map the orientation for analysis of the margins.

[0011] The positron emission tomography (PET) tissue sample imager of the present invention uses a pair of small PET cameras to image radiotracer uptake in excised tissue samples. Cancerous tissue is typically identified as one or more focal regions of increased radiotracer accumula...

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Abstract

A small, mobile imaging system that combines both imaging and optical imaging into a single system that can be located in the operating room (OR) and provide rapid feedback to determine whether a tumor has been adequately resected and whether there is Adequate surgical margins. Such a device may reduce the overall time required for the procedure and reduce the number of iterations required to achieve satisfactory resection of the tumor with good margins, although final confirmation is still to be obtained from the pathology laboratory.

Description

[0001] The United States has certain rights in this invention pursuant to US Department of Energy Management and Operating Contract DE-AC05-060R23177. technical field [0002] The present invention relates to positron emission tomography (PET) imaging, and more particularly to combined PET and optical imaging systems for rapidly determining adequate cancerous tissue resection and surgical procedures during surgical procedures for removal of cancerous tissue. Surgical margin. Background technique [0003] During cancer surgery, one of the important issues is to determine whether there are satisfactory surgical margins around the cancerous tissue. Ideally, the surgeon wants to remove all the tumor and leave enough margin around the cancerous tissue, but not take out too much healthy surrounding tissue. Typically, after surgical removal of the diseased portion, the tissue is sent to a pathology laboratory to determine whether the margins around the cancer are adequate. This p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01T1/166
CPCG01N23/046G01T1/2985G01T1/1603G01N2223/419A61B6/037
Inventor S·W·法勒恩R·A·豪佛S·马杰斯科J·麦克森B·科罗斯J·伯罗佛特A·斯德林A·G·维森伯格
Owner JEFFERSON SCI ASSOCS LLC
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