Composition for inducing th2 cells, therapeutic composition for th2 type disease, and use of the composition

一种细胞诱导、组合物的技术，应用在动物细胞、疾病诊断、皮肤疾病等方向，能够解决先天性免疫细胞作用未得到的足够认识等问题

Inactive Publication Date: 2011-11-30
HYOGO COLLEGE OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the role of the development of Th2-type immune responses on innate immune cells is hardly fully understood

Method used

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  • Composition for inducing th2 cells, therapeutic composition for th2 type disease, and use of the composition
  • Composition for inducing th2 cells, therapeutic composition for th2 type disease, and use of the composition
  • Composition for inducing th2 cells, therapeutic composition for th2 type disease, and use of the composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0118] (1. Materials and methods)

[0119] (mouse)

[0120] BALB / c mice were purchased from Jackson Laboratory, USA. In the animal facility of Hyogo University of Medicine, Japan, OVA was recognized under SPF conditions. 323-339 (DO11.10) αβTCR transgenic mice were mated with BALB / c G4 homozygous (IL-4 deficient) mice. All animal experiments were performed in accordance with the guidelines of the Institutional Animal Care Committee of Hyogo College of Medicine, Japan.

[0121] (cell purification)

[0122] According to previous reports (Kondo, Y. et al. Int Immunol 20, 791-800 (2008) and Yoshimoto, T. et al. Proc Natl Acad Sci US A 96, 13962-6 (1999)), prepared from small Basophils and obese cells in murine bone marrow. The purity of the purified cell population was over 96%. Human basophils and mouse CD4 + CD62L + Details and purification steps for resting T cells are as follows.

[0123] (in vitro culture)

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PUM

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Abstract

The present invention provides a complex of an antigen and IgE binding to the antigen, a composition including an antigen and IgE binding to the antigen, and a method of using the complex or the composition. With the present invention, it is possible to induce naive T cells to develop into Th2 cells. Moreover, the present invention clarified a working mechanism of a Th2-type immune response, particularly a production mechanism of early IL-4. With use of the present invention, it is possible to provide a technique of treating and preventing Th2-type diseases.

Description

technical field [0001] The present invention relates to a composition for inducing Th2 cells and the utilization of the composition, in particular to a composition for producing initial IL-4 which induces Th2 type immune response and the utilization of the composition. In addition, the present invention relates to a composition for treating Th2-type diseases and the utilization of the composition, in particular to a composition for blocking the production of initial IL-4 that causes Th2-type immune response and the composition use. Background technique [0002] When macrophages or dendritic cells are invaded by bacteria, dendritic cells (DC; Dendritic cell) recognize bacteria through Toll-like receptors (TLR; Toll-like receptors), and mature enough to express stimulatory accessory molecules and produce useful IL-12 and IL-18, etc., are used to induce Th1-type immune responses. Naive T cells combine with macrophages or dendritic cells through these molecules, and differenti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N5/07A23K1/16A61K39/395A61K45/00A61P1/00A61P11/02A61P11/06A61P17/00A61P27/02A61P37/02A61P37/08A61P43/00C07K14/54C07K16/28C12Q1/02G01N33/15G01N33/50G01N33/53
CPCG01N2800/122A61K2039/5158A61K47/48776G01N33/505A61K49/0008G01N33/5088A61K39/39583G01N2800/24A61K2039/57C12N5/0636C12N2502/11G01N33/5047A61K2039/6056C12N5/0642A61K47/6901A61P1/00A61P11/02A61P11/06A61P17/00A61P27/02A61P37/02A61P37/08A61P43/00A61K2300/00
Inventor 中西憲司善本知広
Owner HYOGO COLLEGE OF MEDICINE
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