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A method for extracting total phenylpropanoid glycosides from Guangdong purple pearl

A technology of total phenylpropanoid glycosides and purple beads, which is applied in the field of natural medicinal chemistry, can solve the problems of large amount of total phenylpropanoid glycoside organic reagents, pollution, and high energy consumption, and achieve high product quality, simple process operation, and low energy consumption. low effect

Inactive Publication Date: 2011-11-30
NANJING ZELANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

However, most existing methods for extracting total phenylpropanoid glycosides from Guangdong Zizhu have shortcomings such as large amount of organic reagents, high energy consumption, and serious pollution.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Guangdong Zizhu medicinal materials were cut into sections, 5 kg were taken, put into a microwave extraction tank, 40 kg of water was added for microwave extraction for 30 minutes, extracted twice, and the combined extract was filtered through a hollow cellulose membrane with a molecular weight cut-off of 2000. Ultrafiltration, the collected permeate was added to the interception A hollow cellulose membrane system with a molecular weight of 300 is concentrated. The concentrated solution is added to the activated carbon column (loaded with 300g granular activated carbon), after the adsorption, take 4BV50% ethanol solution to elute impurities, and then use 5BV90% ethanol to elute the target component, collect the target component, concentrate under reduced pressure, and vacuum dry to obtain total benzene Pyridin glycosides 102g, content 88%.

Embodiment 2

[0017] Guangdong Zizhu medicinal materials were cut into sections, 5 kg were taken, put into a microwave extraction tank, 25 kg of water was added for microwave extraction for 30 minutes, extracted 3 times, and the combined extract was filtered through a hollow cellulose membrane with a molecular weight cut-off of 5000. Ultrafiltration, the collected permeate was added to the interception A hollow cellulose membrane system with a molecular weight of 100 is concentrated. The concentrated solution was added to the activated carbon column (loaded with 500g granular activated carbon). After the adsorption, 5BV 30% ethanol solution was taken to elute the impurities, and then 3BV 95% ethanol was used to elute the target component. The target component was collected, concentrated under reduced pressure, and vacuum-dried to obtain total benzene. 125g of pyranoid glycosides, the content is 81%.

Embodiment 3

[0019] Guangdong Zizhu medicinal materials were cut into sections, 5kg was put into a microwave extraction tank, 40kg of water was added for microwave extraction for 30 minutes, extracted twice, the combined extract was filtered through a hollow cellulose membrane with a molecular weight cut-off of 3000, and the collected permeate was added to the interception A hollow cellulose membrane system with a molecular weight of 200 is concentrated. The concentrated solution is added to the activated carbon column (loaded with 400g granular activated carbon), after the adsorption is completed, 4BV50% ethanol solution is taken to elute impurities, and then 5BV90% ethanol is used to elute the target component, collect the target component, concentrate under reduced pressure, and vacuum dry to obtain total benzene Pyridin glycosides 110g, content 83%.

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Abstract

The invention discloses a method for extracting total phenylpropanoid glycosides from Guangdong Zizhu, which is characterized in that: Guangdong Zizhu medicinal material is cut into sections, added with 5-10 times the amount of aqueous solution for microwave extraction for 2-3 times, and the extract is used for filtering Ultrafiltration membrane ultrafiltration, the collected permeate is added to the nanofiltration membrane system for concentration, the collected concentrated solution is added to the activated carbon column for adsorption, ethanol solution gradient elution, the target components are collected, concentrated and dried under reduced pressure to obtain the total phenylpropanoid glycosides. The method of the invention has the advantages of simple operation, high extraction rate, low energy consumption, little pollution and easy industrial production.

Description

technical field [0001] The invention belongs to the field of natural medicinal chemistry, in particular to a method for extracting total phenylpropanoid glycosides from Guangdong Zizhu. Background technique [0002] Guangdong Zizhu is a plant of the Verbena family, and its stems and leaves are used as medicine. It has the functions of astringent and hemostasis, dispersing blood stasis, clearing away heat and detoxifying. Commonly used for epistaxis, hemoptysis, hematemesis, hematochezia, metrorrhagia, traumatic bleeding, cough due to lung heat, sore throat, heat-toxic sore, water-fire scald. Modern research has found that purple beads contain flavonoids, phenylpropanoid glycosides, polysaccharides and volatile oils. Among them, phenylpropanoid glycosides are the index components and functional components of Zizhu, mainly including forsythiaside B, chrysoside, cistanoside C, cistancheoside D and isoeugenol glycoside. "Pharmacopoeia of the People's Republic of China"-2010 e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/85A61P7/04A61P11/14A61P11/04A61P17/02A61K127/00A61K135/00
Inventor 刘东锋杨成东
Owner NANJING ZELANG MEDICAL TECH
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