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The preparation method of total paeoniflorin

A technology of total paeoniflorin and white peony, which is applied in the field of preparation of total paeoniflorin, which can solve the problems of difficult regeneration of resin, low adsorption capacity of total paeoniflorin, and high cost of extract, and achieve short operation time, clear extract and low cost Effect

Active Publication Date: 2011-11-30
北京采瑞医药科技研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When using the above method for extraction, in addition to extracting total glycosides of paeony, more impurities are also dissolved out, resulting in turbidity of the extract, which is difficult to clarify by low-temperature refrigeration precipitation, filtration or centrifugation, which easily causes clogging of the resin column and difficult operation. Glycosides have a low specific adsorption capacity, and impurities adsorbed on the resin are not easy to desorb, which makes the resin difficult to regenerate and use, and is not suitable for industrial production. The resulting extract has high cost and low content

Method used

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  • The preparation method of total paeoniflorin

Examples

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Effect test

Embodiment 1

[0039] Take 750g of Radix Paeoniae Alba produced in Zhongjiang, Sichuan, add 4 times the amount of medicinal material in the percolator, add the medicinal material of Radix Paeoniae Alba, soak for 2 hours and percolate, the flow rate is 1 times the amount of medicinal materials per hour, and collect 7 times the amount of medicinal materials for percolation. solution, concentrated under reduced pressure to a relative density of 1.05 to 1.07 (measured at 60°C), filtered to obtain an extract for later use. Take 500 g of ME-1 macroporous adsorption resin and pack it into a column. Take the above extract, pass it through the macroporous adsorption resin column, the flow rate is 2 times the amount of resin per hour, and discard the effluent. Rinse the resin column with 10% methanol solvent 3 times the amount of resin, flow rate is 3 times the amount of resin / hour, and discard the effluent. Rinse the resin column with 4 times the amount of resin and 40% methanol solvent, the flow ra...

Embodiment 2

[0043] Take 750g of Radix Paeoniae Alba produced in Bozhou, Anhui Province, add 4 times the amount of water in the percolator, add Radix Paeoniae Alba, soak for 2 hours, and percolate at a flow rate of 2 times the amount of medicinal materials per hour, and collect 10 times the amount of medicinal materials for percolation. solution, concentrated under reduced pressure to a relative density of 1.09 (measured at 60°C), filtered to obtain an extract for later use. Take 500 g of D-101 macroporous adsorption resin and pack it into a column. Take the above extract, pass it through a macroporous adsorption resin column at a flow rate of 3 times the amount of resin per hour, and discard the effluent. Rinse the resin column with water 3 times the resin volume at a flow rate of 3 times the resin volume / hour, and discard the effluent. Rinse the resin column with 3 times the amount of resin and 50% ethanol solvent, the flow rate is 3 times the amount of resin per hour, collect the 50% m...

Embodiment 3

[0046] Take 480g of Radix Paeoniae Rubra from Inner Mongolia, add 5 times the amount of medicinal material to the percolator, add the Radix Paeoniae Rubra Radix, soak for 1 hour, and percolate at a flow rate of 2.5 times the amount of medicinal materials per hour, and collect 12 times the amount of medicinal materials. , concentrated under reduced pressure to a relative density of 1.06 (measured at 60°C), filtered to obtain an extract for later use. Take 500 g of D-101 macroporous adsorption resin and pack it into a column. Take the above extract, pass it through a macroporous adsorption resin column at a flow rate of 1 times the amount of resin per hour, and discard the effluent. Rinse the resin column with 10% ethanol solution 4 times the amount of resin, flow rate is 2 times the amount of resin / hour, and discard the effluent. Rinse the resin column with 6 times the amount of resin and 35% ethanol solvent, flow rate is 2 times the amount of resin per hour, collect 35% ethan...

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Abstract

The invention provides a preparation method of peony general glycoside, which comprises the following steps: soaking radix paeoniae alba or red paeonia in 2-10 times (weight) of hydrophilic solvent, wherein the hydrophilic solvent is water or a water solution containing less than 30% of methanol, ethanol, propanol and isopropanol; after soaking, percolating at low temperature of 5-40 DEG C; and concentrating the percolate, filtering to obtain the extracting solution, and passing the extracting solution through macroporous resin. The transfer rate of penoniflorin and peony Albiflorin is 85-90%, and the purity of the peony general glycoside extract is high.

Description

technical field [0001] The invention relates to a method for preparing total glycosides of paeoniflorin, which belongs to the field of traditional Chinese medicines. technical background [0002] Total paeoniflorin is a general term for a class of active ingredients of traditional Chinese medicine that were first isolated and discovered from peonies, so this type of monoterpene glycosides is called total paeoniflorin. There are more than ten kinds of paeoniflorin, paeoniflorin, hydroxypaeoniflorin, benzoylpaeoniflorin, paeoniflorinone, paeoniflorin and paeoniflorin R1. A variety of Chinese medicinal materials contain such ingredients, but the types and contents are not the same. Radix Paeoniae Rubra mainly contains paeoniflorin, and the content of paeoniflorin is less or not contained; The content of lactone glycosides is high; besides paeoniflorin, Moutan cortex also contains benzoylhydroxypaeoniflorin. Total paeoniflorin has strong pharmacological activities, mainly anti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61P25/22A61P21/02A61P25/24A61P25/28A61P7/00A61P29/00A61P37/04
Inventor 张建军李伟王景霞
Owner 北京采瑞医药科技研究院有限公司
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